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Article

1 Citations

1,955 Views

22 Pages

Generating a Cell Model to Study ER Stress in iPSC-Derived Medium Spiny Neurons from a Patient with Huntington’s Disease

Vladlena S. Makeeva,
Anton Yu. Sivkov,
Suren M. Zakian and
Anastasia A. Malakhova

Int. J. Mol. Sci.2025, 26(18), 8930;https://doi.org/10.3390/ijms26188930

13 September 2025

iPSCs and their derivatives are used to investigate the molecular genetic mechanisms of human diseases, to identify therapeutic targets, and to screen for small molecules. Combining technologies for generating patient-specific iPSC lines and genome e...

(This article belongs to the Section Molecular Neurobiology)

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Article

10 Citations

3,960 Views

23 Pages

Detection of ER Stress in iPSC-Derived Neurons Carrying the p.N370S Mutation in the GBA1 Gene

Elena S. Yarkova,
Elena V. Grigor’eva,
Sergey P. Medvedev,
Denis A. Tarasevich and ,
Sophia V. Pavlova,
Kamila R. Valetdinova,
Julia M. Minina,
Suren M. Zakian and
Anastasia A. Malakhova
+ 4 authors+ 0 author

Biomedicines2024, 12(4), 744;https://doi.org/10.3390/biomedicines12040744

27 March 2024

Endoplasmic reticulum (ER) stress is involved in the pathogenesis of many human diseases, such as cancer, type 2 diabetes, kidney disease, atherosclerosis and neurodegenerative diseases, in particular Parkinson’s disease (PD). Since there is cu...

(This article belongs to the Special Issue Pluripotent Stem Cell: Current Understanding and Future Directions)

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