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Article

11 Citations

4,893 Views

15 Pages

The PDE4 Inhibitor Tanimilast Restrains the Tissue-Damaging Properties of Human Neutrophils

Tiziana Schioppa,
Hoang Oanh Nguyen,
Valentina Salvi,
Norma Maugeri and ,
Fabrizio Facchinetti,
Gino Villetti,
Maurizio Civelli,
Carolina Gaudenzi,
Mauro Passari and
Laura Tiberio
+ 11 authors+ 6 authors

Int. J. Mol. Sci.2022, 23(9), 4982;https://doi.org/10.3390/ijms23094982

29 April 2022

Neutrophils, the most abundant subset of leukocytes in the blood, play a pivotal role in host response against invading pathogens. However, in respiratory diseases, excessive infiltration and activation of neutrophils can lead to tissue damage. Tanim...

(This article belongs to the Special Issue Mechanisms of Innate Immune Activation and Regulation in Health and Disease)

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Review

9 Citations

4,485 Views

21 Pages

Modulation of Human Dendritic Cell Functions by Phosphodiesterase-4 Inhibitors: Potential Relevance for the Treatment of Respiratory Diseases

Hoang Oanh Nguyen,
Laura Tiberio,
Fabrizio Facchinetti,
Giulia Ripari and ,
Valentina Violi,
Gino Villetti,
Valentina Salvi and
Daniela Bosisio
+ 3 authors+ 0 author

Pharmaceutics2023, 15(9), 2254;https://doi.org/10.3390/pharmaceutics15092254

31 August 2023

Inhibitors of phosphodiesterase-4 (PDE4) are small-molecule drugs that, by increasing the intracellular levels of cAMP in immune cells, elicit a broad spectrum of anti-inflammatory effects. As such, PDE4 inhibitors are actively studied as therapeutic...

(This article belongs to the Section Clinical Pharmaceutics)

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