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9 Results Found

  • Article
  • Open Access
5 Citations
4,903 Views
13 Pages
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A Novel Method of Mouse RPE Explant Culture and Effective Introduction of Transgenes Using Adenoviral Transduction for In Vitro Studies in AMD

  • Peng Shang,
  • Nadezda A. Stepicheva,
  • Haitao Liu,
  • Olivia Chowdhury,
  • Jonathan Franks,
  • Ming Sun,
  • Stacey Hose,
  • Sayan Ghosh,
  • Meysam Yazdankhah and
  • Debasish Sinha
  • + 3 authors
Int. J. Mol. Sci.2021, 22(21), 11979;https://doi.org/10.3390/ijms222111979

5 November 2021

Degeneration of retinal pigment epithelium (RPE) is one of the most critical phenotypic changes of age-related macular degeneration (AMD), the leading cause of vision loss in the elderly. While cultured polarized RPE cells with original properties ar...

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  • Open Access
21 Citations
5,214 Views
20 Pages
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Fine Tuning of an Oxidative Stress Model with Sodium Iodate Revealed Protective Effect of NF-κB Inhibition and Sex-Specific Difference in Susceptibility of the Retinal Pigment Epithelium

  • Xue Yang,
  • Usha Rai,
  • Jin-Yong Chung and
  • Noriko Esumi
Antioxidants2022, 11(1), 103;https://doi.org/10.3390/antiox11010103

31 December 2021

Oxidative stress of the retinal pigment epithelium (RPE) is a major risk factor for age-related macular degeneration (AMD). As a dry AMD model via oxidative stress, sodium iodate (NaIO3), which is primarily toxic to the RPE, has often been used at a...

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  • Article
  • Open Access
14 Citations
4,414 Views
15 Pages
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The Histone Deacetylase Inhibitor AN7, Attenuates Choroidal Neovascularization in a Mouse Model

  • Mor Dahbash,
  • Ruti Sella,
  • Elinor Megiddo-Barnir,
  • Yael Nisgav,
  • Nataly Tarasenko,
  • Dov Weinberger,
  • Ada Rephaeli and
  • Tami Livnat
Int. J. Mol. Sci.2019, 20(3), 714;https://doi.org/10.3390/ijms20030714

7 February 2019

Choroidal neovascularization (CNV) is a complication of age-related macular degeneration and a major contributing factor to vision loss. In this paper, we show that in a mouse model of laser-induced CNV, systemic administration of Butyroyloxymethyl-d...

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  • Open Access
7 Citations
3,304 Views
14 Pages
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Buspirone Enhances Cell Survival and Preserves Structural Integrity during Oxidative Injury to the Retinal Pigment Epithelium

  • Manas R. Biswal,
  • Ryan J. Paulson,
  • Riddhi Vichare and
  • Alfred S. Lewin
Antioxidants2023, 12(12), 2129;https://doi.org/10.3390/antiox12122129

17 December 2023

Chronic oxidative stress impairs the normal functioning of the retinal pigment epithelium (RPE), leading to atrophy of this cell layer in cases of advance age-related macular degeneration (AMD). The purpose of our study was to determine if buspirone,...

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  • Open Access
3 Citations
2,546 Views
8 Pages
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Fluorescence Lifetime Imaging of Human Sub-RPE Calcification In Vitro Following Chlortetracycline Infusion

  • Kavita R. Hegde,
  • Adam C. Puche,
  • Henryk Szmacinski,
  • Kristina Fuller,
  • Krishanu Ray,
  • Nikita Patel,
  • Imre Lengyel and
  • Richard B. Thompson
Int. J. Mol. Sci.2023, 24(7), 6421;https://doi.org/10.3390/ijms24076421

29 March 2023

We have shown that all sub-retinal pigment epithelial (sub-RPE) deposits examined contain calcium phosphate minerals: hydroxyapatite (HAP), whitlockite (Wht), or both. These typically take the form of ca. 1 μm diameter spherules or >10 μm no...

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  • Open Access
6 Citations
4,007 Views
10 Pages
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Ex Vivo Hyperspectral Autofluorescence Imaging and Localization of Fluorophores in Human Eyes with Age-Related Macular Degeneration

  • Taariq Mohammed,
  • Yuehong Tong,
  • Julia Agee,
  • Nayanika Challa,
  • Rainer Heintzmann,
  • Martin Hammer,
  • Christine A. Curcio,
  • Thomas Ach,
  • Zsolt Ablonczy and
  • R. Theodore Smith
Vision2018, 2(4), 38;https://doi.org/10.3390/vision2040038

26 September 2018

To characterize fluorophore signals from drusen and retinal pigment epithelium (RPE) and their changes in age related macular degeneration (AMD), the authors describe advances in ex vivo hyperspectral autofluorescence (AF) imaging of human eye tissue...

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  • Open Access
22 Citations
4,088 Views
16 Pages
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Long-Term Oral Treatment with Non-Hypoglycemic Dose of Glibenclamide Reduces Diabetic Retinopathy Damage in the Goto-KakizakiRat Model

  • Marianne Berdugo,
  • Kimberley Delaunay,
  • Cécile Lebon,
  • Marie-Christine Naud,
  • Lolita Radet,
  • Léa Zennaro,
  • Emilie Picard,
  • Alejandra Daruich,
  • Jacques Beltrand and
  • Francine F. Behar-Cohen
  • + 3 authors
Pharmaceutics2021, 13(7), 1095;https://doi.org/10.3390/pharmaceutics13071095

17 July 2021

Diabetic retinopathy (DR) remains a major cause of vision loss, due to macular edema, retinal ischemia and death of retinal neurons. We previously demonstrated that acute administration of glibenclamide into the vitreous, or given orally at a non-hyp...

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  • Open Access
9 Citations
4,204 Views
18 Pages
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Meteorin Is a Novel Therapeutic Target for Wet Age-Related Macular Degeneration

  • Kimberley Delaunay,
  • Alexandre Sellam,
  • Virginie Dinet,
  • Alexandre Moulin,
  • Min Zhao,
  • Emmanuelle Gelizé,
  • Jérémie Canonica,
  • Marie-Christine Naud,
  • Patricia Crisanti-Lassiaz and
  • Francine Behar-Cohen
J. Clin. Med.2021, 10(13), 2973;https://doi.org/10.3390/jcm10132973

2 July 2021

The aim of this study was to evaluate the potential anti-angiogenic effect of MTRN (meteorin) in the laser-induced CNV rat model and explore its mechanisms of action. MTRN, thrompospondin-1, glial cell markers (GFAP, vimentin), and phalloidin were im...

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  • Open Access
9 Citations
3,220 Views
13 Pages
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Activated Protein C (APC) and 3K3A-APC-Induced Regression of Choroidal Neovascularization (CNV) Is Accompanied by Vascular Endothelial Growth Factor (VEGF) Reduction

  • Tami Livnat,
  • Yehonatan Weinberger,
  • José A. Fernández,
  • Alaa Bashir,
  • Gil Ben-David,
  • Dahlia Palevski,
  • Sarina Levy-Mendelovich,
  • Gili Kenet,
  • Ivan Budnik and
  • Dov Weinberger
  • + 2 authors
Biomolecules2021, 11(3), 358;https://doi.org/10.3390/biom11030358

26 February 2021

The activated protein C (APC) ability to inhibit choroidal neovascularization (CNV) growth and leakage was recently shown in a murine model. A modified APC, 3K3A-APC, was designed to reduce anticoagulant activity while maintaining full cytoprotective...

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