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7 Results Found

  • Article
  • Open Access
17 Citations
5,696 Views
19 Pages

27 November 2020

Methylxanthines are a group of substances derived from the purine base xanthine with a methyl group at the nitrogen on position 3 and different residues at the nitrogen on position 1 and 7. They are widely consumed in nutrition and used as pharmaceut...

  • Article
  • Open Access
10 Citations
2,354 Views
11 Pages

Propentofylline Improves Thiol-Based Antioxidant Defenses and Limits Lipid Peroxidation following Gliotoxic Injury in the Rat Brainstem

  • Deborah E. M. Baliellas,
  • Marcelo P. Barros,
  • Cristina V. Vardaris,
  • Maísa Guariroba,
  • Sandra C. Poppe,
  • Maria F. Martins,
  • Álvaro A. F. Pereira and
  • Eduardo F. Bondan

Propentofylline (PROP) is a methylated xanthine compound that diminishes the activation of microglial cells and astrocytes, which are neuronal cells strongly associated with many neurodegenerative diseases. Based on previously observed remyelination...

  • Article
  • Open Access
7 Citations
1,548 Views
9 Pages

17 February 2009

Three dehydrogenases – (R)-alcohol dehydrogenase from L. kefir, (S)-aromatic alcohol dehydrogenase from T. sp. and (S)-alcohol dehydrogenase from T. brockii – were tested for the preparation of enantiopure hydroxyl metabolites of pentoxifylline (PTX)...

  • Article
  • Open Access
7 Citations
5,189 Views
20 Pages

Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells

  • Daniel Janitschke,
  • Anna Andrea Lauer,
  • Cornel Manuel Bachmann,
  • Jakob Winkler,
  • Lea Victoria Griebsch,
  • Sabrina Melanie Pilz,
  • Elena Leoni Theiss,
  • Heike Sabine Grimm,
  • Tobias Hartmann and
  • Marcus Otto Walter Grimm

18 February 2022

Alzheimer’s disease (AD) is characterized by an increased plaque burden and tangle accumulation in the brain accompanied by extensive lipid alterations. Methylxanthines (MTXs) are alkaloids frequently consumed by dietary intake known to interfe...

  • Feature Paper
  • Article
  • Open Access
28 Citations
8,029 Views
22 Pages

Effect of Caffeine and Other Methylxanthines on Aβ-Homeostasis in SH-SY5Y Cells

  • Daniel Janitschke,
  • Christopher Nelke,
  • Anna Andrea Lauer,
  • Liesa Regner,
  • Jakob Winkler,
  • Andrea Thiel,
  • Heike Sabine Grimm,
  • Tobias Hartmann and
  • Marcus Otto Walter Grimm

2 November 2019

Methylxanthines (MTX) are alkaloids derived from the purine-base xanthine. Whereas especially caffeine, the most prominent known MTX, has been formerly assessed to be detrimental, this point of view has changed substantially. MTXs are discussed to ha...

  • Review
  • Open Access
47 Citations
9,318 Views
18 Pages

Methylxanthines and Neurodegenerative Diseases: An Update

  • Daniel Janitschke,
  • Anna A. Lauer,
  • Cornel M. Bachmann,
  • Heike S. Grimm,
  • Tobias Hartmann and
  • Marcus O. W. Grimm

28 February 2021

Methylxanthines (MTX) are purine derived xanthine derivatives. Whereas naturally occurring methylxanthines like caffeine, theophylline or theobromine are widely consumed in food, several synthetic but also non-synthetic methylxanthines are used as ph...

  • Article
  • Open Access
1 Citations
1,714 Views
19 Pages

13 March 2025

Soil salinization threatens global agriculture, reducing crop productivity and food security. Developing strategies to improve salt tolerance is crucial for sustainable agriculture. This study examines the role of organic fertilizer in mitigating sal...