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8 Results Found

  • Article
  • Open Access
11 Citations
3,198 Views
12 Pages
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F4-Neuroprostanes: A Role in Sperm Capacitation

  • Cinzia Signorini,
  • Elena Moretti,
  • Daria Noto,
  • Simona Mattioli,
  • Cesare Castellini,
  • Nicola Antonio Pascarelli,
  • Thierry Durand,
  • Camille Oger,
  • Jean-Marie Galano and
  • Giulia Collodel
  • + 2 authors
Life2021, 11(7), 655;https://doi.org/10.3390/life11070655

5 July 2021

F4-neuroprostanes (F4-NeuroPs), derived from the oxidative metabolization of docosahexaenoic acid (DHA), are considered biomarkers of oxidative stress in neurodegenerative diseases. Neurons and spermatozoa display a high DHA content. NeuroPs might po...

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  • Article
  • Open Access
14 Citations
4,303 Views
15 Pages
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Protective Effect of Chlorogenic Acid on Human Sperm: In Vitro Studies and Frozen–Thawed Protocol

  • Daria Noto,
  • Giulia Collodel,
  • Daniela Cerretani,
  • Cinzia Signorini,
  • Laura Gambera,
  • Andrea Menchiari and
  • Elena Moretti
Antioxidants2021, 10(5), 744;https://doi.org/10.3390/antiox10050744

7 May 2021

The study evaluated the chlorogenic acid (CGA) antioxidant potential on oxidative stress (OS) induced in vitro in human spermatozoa and during cryopreservation procedure. Swim-up selected spermatozoa were treated with 100 µM CGA, 100 µM H2O2 to induc...

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  • Article
  • Open Access
2 Citations
2,377 Views
21 Pages
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Excess Potassium Promotes Autophagy to Maintain the Immunosuppressive Capacity of Myeloid-Derived Suppressor Cells Independent of Arginase 1

  • Ramesh Thylur Puttalingaiah,
  • Matthew J. Dean,
  • Liqin Zheng,
  • Phaethon Philbrook,
  • Dorota Wyczechowska,
  • Timothy Kayes,
  • Luis Del Valle,
  • Denise Danos and
  • Maria Dulfary Sanchez-Pino
Cells2024, 13(20), 1736;https://doi.org/10.3390/cells13201736

19 October 2024

Potassium ions (K+) are critical electrolytes that regulate multiple functions in immune cells. Recent studies have shown that the elevated concentration of extracellular potassium in the tumor interstitial fluid limits T cell effector function and s...

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  • Article
  • Open Access
11 Citations
4,381 Views
20 Pages
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The Marine-Derived Macrolactone Mandelalide A Is an Indirect Activator of AMPK

  • Daphne R. Mattos,
  • Xuemei Wan,
  • Jeffrey D. Serrill,
  • Minh H. Nguyen,
  • Ian R. Humphreys,
  • Benoit Viollet,
  • Amos B. Smith,
  • Kerry L. McPhail and
  • Jane E. Ishmael
Mar. Drugs2022, 20(7), 418;https://doi.org/10.3390/md20070418

27 June 2022

The mandelalides are complex macrolactone natural products with distinct macrocycle motifs and a bioactivity profile that is heavily influenced by compound glycosylation. Mandelalides A and B are direct inhibitors of mitochondrial ATP synthase (compl...

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  • Article
  • Open Access
17 Citations
4,373 Views
12 Pages
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A Multi-Ingredient Formula Ameliorates Exercise-Induced Fatigue by Changing Metabolic Pathways and Increasing Antioxidant Capacity in Mice

  • Hui Chen,
  • Xuan Ma,
  • Lixing Cao,
  • Shuang Zhao,
  • Chong Zhao,
  • Shutao Yin and
  • Hongbo Hu
Foods2021, 10(12), 3120;https://doi.org/10.3390/foods10123120

16 December 2021

Multiple mechanisms are involved in exercise-induced fatigue, including energy depletion, metabolite accumulation, and oxidative stress, etc. The mechanistic findings provide a rationale for a multi-targeted approach to exercise-induced fatigue manag...

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  • Article
  • Open Access
6 Citations
3,976 Views
13 Pages
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Modulation of Renal Injury by Variable Expression of Myo-Inositol Oxygenase (MIOX) via Perturbation in Metabolic Sensors

  • Isha Sharma,
  • Fei Deng and
  • Yashpal S. Kanwar
Biomedicines2020, 8(7), 217;https://doi.org/10.3390/biomedicines8070217

16 July 2020

Obesity is associated with perturbations in cellular energy homeostasis and consequential renal injury leading to chronic renal disease (CKD). Myo-inositol oxygenase (MIOX), a tubular enzyme, alters redox balance and subsequent tubular injury in the...

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  • Article
  • Open Access
7 Citations
4,274 Views
20 Pages
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Protective Effects of Echinacea purpurea Ethanol Extract on Male Reproductive Dysfunction in Obese Rats

  • Zwe-Ling Kong,
  • Athira Johnson,
  • Tzu-Ling Ting,
  • Po-Jen Cheng and
  • Chien-Feng Mao
Appl. Sci.2021, 11(5), 2392;https://doi.org/10.3390/app11052392

8 March 2021

Obesity is characterized by excessive fat accumulation and it may affect reproductive health by altering the sperm parameters, hormonal profiles, and gonadal functions. Echinacea purpurea is a medicinal herb and is well-known for its anti-inflammator...

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  • Article
  • Open Access
3 Citations
2,804 Views
19 Pages
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Responsiveness to Hedgehog Pathway Inhibitors in T-Cell Acute Lymphoblastic Leukemia Cells Is Highly Dependent on 5′AMP-Activated Kinase Inactivation

  • Valeria Tosello,
  • Deborah Bongiovanni,
  • Ludovica Di Martino,
  • Cinzia Franchin,
  • Paola Zanovello,
  • Giorgio Arrigoni and
  • Erich Piovan
Int. J. Mol. Sci.2021, 22(12), 6384;https://doi.org/10.3390/ijms22126384

15 June 2021

Numerous studies have shown that hedgehog inhibitors (iHHs) only partially block the growth of tumor cells, especially in vivo. Leukemia often expands in a nutrient-depleted environment (bone marrow and thymus). In order to identify putative signalin...

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