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A Multi-Ingredient Formula Ameliorates Exercise-Induced Fatigue by Changing Metabolic Pathways and Increasing Antioxidant Capacity in Mice

Department of Food Nutrition and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
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Author to whom correspondence should be addressed.
Academic Editor: Anna Jakubczyk
Foods 2021, 10(12), 3120; https://doi.org/10.3390/foods10123120
Received: 9 November 2021 / Revised: 12 December 2021 / Accepted: 14 December 2021 / Published: 16 December 2021
(This article belongs to the Section Food Nutrition)
Multiple mechanisms are involved in exercise-induced fatigue, including energy depletion, metabolite accumulation, and oxidative stress, etc. The mechanistic findings provide a rationale for a multi-targeted approach to exercise-induced fatigue management. This study created a multi-ingredient formula mixed with valine, isoleucine, leucine, β-alanine, creatine, l-carnitine, quercetin, and betaine, based on the functional characteristics of these agents, and evaluated the preventive effect of this mechanism-based formula on exercise-induced fatigue. Results showed that the 7-d formula supplement significantly increased the running duration time of mice by 14% and the distance by 20% in an exhaustive treadmill test, indicating that the formula could delay fatigue appearance and improve exercise performance. Mechanistically, the formula enhanced fatty acid oxidation and spared liver glycogen by regulating the fat/glucose metabolism-related signaling pathways, including phospho-adenosine monophosphate-activated protein kinase α (p-AMPKα), phospho-acetyl CoA carboxylase (p-ACC), carnitine palmitoyl-transferase 1B (CPT1B), fatty acid translocase (CD36), and glucose transporter type 4 (GLUT4), and increased antioxidant capacity. The findings suggested that the formula tested in this study effectively ameliorated exercise-induced fatigue by targeting multi-signaling pathways, showing promise as a regimen to fight exercise-induced fatigue. View Full-Text
Keywords: exercise-induced fatigue; formula; fat/glucose metabolisms; oxidative stress exercise-induced fatigue; formula; fat/glucose metabolisms; oxidative stress
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MDPI and ACS Style

Chen, H.; Ma, X.; Cao, L.; Zhao, S.; Zhao, C.; Yin, S.; Hu, H. A Multi-Ingredient Formula Ameliorates Exercise-Induced Fatigue by Changing Metabolic Pathways and Increasing Antioxidant Capacity in Mice. Foods 2021, 10, 3120. https://doi.org/10.3390/foods10123120

AMA Style

Chen H, Ma X, Cao L, Zhao S, Zhao C, Yin S, Hu H. A Multi-Ingredient Formula Ameliorates Exercise-Induced Fatigue by Changing Metabolic Pathways and Increasing Antioxidant Capacity in Mice. Foods. 2021; 10(12):3120. https://doi.org/10.3390/foods10123120

Chicago/Turabian Style

Chen, Hui, Xuan Ma, Lixing Cao, Shuang Zhao, Chong Zhao, Shutao Yin, and Hongbo Hu. 2021. "A Multi-Ingredient Formula Ameliorates Exercise-Induced Fatigue by Changing Metabolic Pathways and Increasing Antioxidant Capacity in Mice" Foods 10, no. 12: 3120. https://doi.org/10.3390/foods10123120

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