You are currently on the new version of our website. Access the old version .

17 Results Found

  • Feature Paper
  • Review
  • Open Access
54 Citations
16,609 Views
28 Pages

Regenerative Endodontic Procedures Using Contemporary Endodontic Materials

  • Simone Staffoli,
  • Gianluca Plotino,
  • Barbara G. Nunez Torrijos,
  • Nicola M. Grande,
  • Maurizio Bossù,
  • Gianluca Gambarini and
  • Antonella Polimeni

19 March 2019

Calcium hydroxide apexification and Mineral Trioxide Aggregate (MTA) apexification are classical treatments for necrotic immature permanent teeth. The first tend to fail for lack of compliance given the high number of sessions needed; the second has...

  • Case Report
  • Open Access
5 Citations
4,633 Views
9 Pages

9 May 2022

Revascularization has been incorporated into endodontic practice and become a viable treatment alternative for immature teeth with pulp necrosis. Thorough disinfection of the root canal is a key factor for successful revascularization. An erbium: ytt...

  • Systematic Review
  • Open Access
29 Citations
12,667 Views
35 Pages

5 July 2022

This systematic review aimed to evaluate interventions individually and compare the clinical outcome of young, immature teeth treated with regenerative endodontic therapy (RET) and apexification procedure. The protocol was registered with PROSPERO (I...

  • Case Report
  • Open Access
16 Citations
10,013 Views
6 Pages

1 January 2019

Traditionally, immature teeth diagnosed with necrotic pulp and periapical periodontitis were treated by apexification with long-term calcium hydroxide or in one session with mineral trioxide aggregate (MTA) or Biodentine apical plug. However, these t...

  • Case Report
  • Open Access
66 Citations
8,144 Views
13 Pages

Does Apical Papilla Survive and Develop in Apical Periodontitis Presence after Regenerative Endodontic Procedures?

  • Paulo J. Palma,
  • João Martins,
  • Patrícia Diogo,
  • Diana Sequeira,
  • João Carlos Ramos,
  • Aníbal Diogenes and
  • João Miguel Santos

20 September 2019

Regenerative endodontic procedures (REPs) have emerged as a treatment option for immature necrotic teeth to allow the reestablishment of a newly formed vital tissue and enable continued root development. The apical papilla stem cells (SCAPs) play an...

  • Article
  • Open Access
18 Citations
6,021 Views
14 Pages

In Vivo Evaluation of Decellularized Human Tooth Scaffold for Dental Tissue Regeneration

  • Ik-Hwan Kim,
  • Mijeong Jeon,
  • Kyounga Cheon,
  • Sun Ha Kim,
  • Han-Sung Jung,
  • Yooseok Shin,
  • Chung Min Kang,
  • Seong-Oh Kim,
  • Hyung-Jun Choi and
  • Je Seon Song
  • + 2 authors

13 September 2021

Conventional root canal treatment may result in loss of tooth vitality, which can lead to unfavorable treatment outcomes. Notably, a ceased tooth development of immature permanent teeth with open apices, regeneration of periodontal ligaments (PDL), a...

  • Article
  • Open Access
7 Citations
3,627 Views
11 Pages

4 July 2022

We assessed the impact of regenerative endodontic procedures (REP) using a platelet-rich fibrin (PRF) scaffold on necrotic immature permanent anterior and posterior teeth based on the following parameters: periapical healing, changes in root developm...

  • Feature Paper
  • Review
  • Open Access
11 Citations
10,366 Views
17 Pages

Regenerative Endodontics as the Future Treatment of Immature Permanent Teeth

  • Justyna Zbańska,
  • Katarzyna Herman,
  • Piotr Kuropka and
  • Maciej Dobrzyński

5 July 2021

The regenerative endodontic procedure (REP) is an alternative solution for endodontic treatment of permanent teeth with incomplete root apex development. It results in angiogenesis, reinnervation, and further root formation. Indications for REP inclu...

  • Article
  • Open Access
7 Citations
2,639 Views
10 Pages

3 December 2022

Tooth germ autotransplantation of open apices of the teeth exhibits high pulpal healing rates, whereas that of mature permanent teeth normally causes irreversible pulpal necrosis. Extraoral root-end resection (EORER) during transplantation may promot...

  • Case Report
  • Open Access
2 Citations
1,937 Views
11 Pages

21 May 2025

Background: The combination of two or more different types of traumatic dental injuries occurring concurrently to the same tooth presents a significant clinical challenge. By focusing on a rare combination of injuries, this case study explores the is...

  • Article
  • Open Access
37 Citations
4,726 Views
16 Pages

Acemannan Used as an Implantable Biomaterial for Vital Pulp Therapy of Immature Permanent Teeth Induced Continued Root Formation

  • Tien Thuy Vu,
  • Minh Truong Nguyen,
  • Polkit Sangvanich,
  • Quang Ngoc Nguyen and
  • Pasutha Thunyakitpisal

Direct pulp-capping, a vital pulp therapy, is used to protect and preserve pulp vitality by applying a biomaterial on the pulp exposure site. Acemannan, a polysaccharide extracted from Aloe vera, induces osteodentin-bridge formation to cover the expo...

  • Article
  • Open Access
761 Views
23 Pages

Advanced Platelet-Rich Fibrin Plus Sealed Exclusively with Glass Ionomer Cement: Setting a New Standard for Healing, Aesthetics and Predictive Modelling in Regenerative Endodontics

  • Dubravka Turjanski,
  • Dragutin Lisjak,
  • Petra Bučević Sojčić,
  • Jelena Valpotić,
  • Tea Borojević Renić,
  • Kristina Goršeta and
  • Domagoj Glavina

22 September 2025

Regenerative endodontic approaches for immature necrotic permanent teeth must balance biological efficacy, clinical practicality and long-term aesthetic outcomes. This study evaluates a novel regenerative protocol using autologous advanced platelet-r...

  • Systematic Review
  • Open Access
507 Views
10 Pages

Tooth Autotransplantation with Immature Donors in Children and Adolescents: A Systematic Review with Quality-Assessed Evidence

  • Esther García-Miralles,
  • Laura Marqués-Martínez,
  • Carla Borrell-García,
  • Paula Boo-Gordillo,
  • Juan-Ignacio Aura-Tormos and
  • Clara Guinot-Barona

26 November 2025

Background: Tooth autotransplantation represents a biologically favourable treatment option for replacing missing or non-restorable teeth in paediatric patients. However, its long-term prognosis and variability in reported success rates warrant a hig...

  • Article
  • Open Access
16 Citations
11,836 Views
19 Pages

16 December 2020

(1) Background: The purpose of this study was to analyze the influence of the chosen diagnostic and therapeutic approach (repositioning and splinting methods) on the risk, frequency and timing of the onset of pulp canal obliteration and pulp necrosis...

  • Article
  • Open Access
715 Views
13 Pages

5 November 2025

Background/Aim: Immature permanent teeth with necrotic pulps present thin dentinal walls and open apices, making them highly susceptible to cervical fractures even after apexification. This study aimed to compare stress distribution patterns produced...

  • Review
  • Open Access
47 Citations
21,752 Views
15 Pages

27 February 2016

Caries is the most common cause of pulp-periapical disease. When the pulp tissue involved in caries becomes irreversibly inflamed and progresses to necrosis, the treatment option is root canal therapy because the infected or non-infected necrotic pul...

  • Review
  • Open Access
7 Citations
7,103 Views
22 Pages

Different Approaches to the Regeneration of Dental Tissues in Regenerative Endodontics

  • Anna M. Krupińska,
  • Katarzyna Skośkiewicz-Malinowska and
  • Tomasz Staniowski

14 February 2021

(1) Background: The regenerative procedure has established a new approach to root canal therapy, to preserve the vital pulp of the tooth. This present review aimed to describe and sum up the different approaches to regenerative endodontic treatment c...