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8 Results Found

  • Article
  • Open Access
2 Citations
2,925 Views
11 Pages
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Associations of the SREBF2 Gene and INSIG2 Polymorphisms with Obesity and Dyslipidemia in Thai Psychotic Disorder Patients Treated with Risperidone

  • Natchaya Vanwong,
  • Chonlaphat Sukasem,
  • Weerapon Unaharassamee,
  • Napa Jiratjintana,
  • Chalitpon Na Nakorn,
  • Yaowaluck Hongkaew and
  • Apichaya Puangpetch
J. Pers. Med.2021, 11(10), 943;https://doi.org/10.3390/jpm11100943

22 September 2021

Background: Patients with psychotic disorders who receive atypical antipsychotic drugs often develop metabolic abnormalities. The sterol regulatory element-binding factor 2 (SREBF2) gene and insulin-induced gene (INSIG) have important roles in lipid...

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  • Open Access
8 Citations
3,047 Views
10 Pages
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Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome

  • Anastasiia S. Boiko,
  • Ivan V. Pozhidaev,
  • Diana Z. Paderina,
  • Irina A. Mednova,
  • Anastasya A. Goncharova,
  • Olga Yu. Fedorenko,
  • Elena G. Kornetova,
  • Arkadiy V. Semke,
  • Nikolay A. Bokhan and
  • Svetlana A. Ivanova
  • + 1 author
Genes2022, 13(5), 844;https://doi.org/10.3390/genes13050844

8 May 2022

Background: Metabolic syndrome (MetS) is a common complication of long-term treatment of persons with schizophrenia taking (atypical) antipsychotics. In this study, we investigated the existence of an association with polymorphisms of genes for four...

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  • Open Access
12 Citations
4,734 Views
18 Pages
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The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity

  • Flaminia Ferri,
  • Simone Carotti,
  • Guido Carpino,
  • Monica Mischitelli,
  • Alfredo Cantafora,
  • Antonio Molinaro,
  • Maria Eva Argenziano,
  • Simona Parisse,
  • Alessandro Corsi and
  • Stefano Ginanni Corradini
  • + 8 authors
Int. J. Mol. Sci.2021, 22(11), 6100;https://doi.org/10.3390/ijms22116100

5 June 2021

In nonalcoholic steatohepatitis animal models, an increased lipid droplet size in hepatocytes is associated with fibrogenesis. Hepatocytes with large droplet (Ld-MaS) or small droplet (Sd-MaS) macrovesicular steatosis may coexist in the human liver,...

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  • Open Access
13 Citations
3,459 Views
13 Pages
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Genome-Wide Association Studies and Runs of Homozygosity to Identify Reproduction-Related Genes in Yorkshire Pig Population

  • Lige Zhang,
  • Songyuan Zhang,
  • Meng Yuan,
  • Fengting Zhan,
  • Mingkun Song,
  • Peng Shang,
  • Feng Yang,
  • Xiuling Li,
  • Ruimin Qiao and
  • Kejun Wang
  • + 3 authors
Genes2023, 14(12), 2133;https://doi.org/10.3390/genes14122133

27 November 2023

Reproductive traits hold considerable economic importance in pig breeding and production. However, candidate genes underpinning the reproductive traits are still poorly identified. In the present study, we executed a genome-wide association study (GW...

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  • Open Access
23 Citations
4,258 Views
11 Pages
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A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study

  • Andreea Ciudin,
  • Enzamaría Fidilio,
  • Liliana Gutiérrez-Carrasquilla,
  • Assumpta Caixàs,
  • Núria Vilarrasa,
  • Silvia Pellitero,
  • Andreu Simó-Servat,
  • Ramon Vilallonga,
  • Amador Ruiz and
  • Albert Lecube
  • + 7 authors
J. Pers. Med.2021, 11(10), 1040;https://doi.org/10.3390/jpm11101040

17 October 2021

Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retro...

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  • Open Access
5 Citations
2,816 Views
16 Pages
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GWAS Enhances Genomic Prediction Accuracy of Caviar Yield, Caviar Color and Body Weight Traits in Sturgeons Using Whole-Genome Sequencing Data

  • Hailiang Song,
  • Tian Dong,
  • Wei Wang,
  • Xiaoyu Yan,
  • Chenfan Geng,
  • Song Bai and
  • Hongxia Hu
Int. J. Mol. Sci.2024, 25(17), 9756;https://doi.org/10.3390/ijms25179756

9 September 2024

Caviar yield, caviar color, and body weight are crucial economic traits in sturgeon breeding. Understanding the molecular mechanisms behind these traits is essential for their genetic improvement. In this study, we performed whole-genome sequencing o...

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  • Open Access
2 Citations
1,834 Views
12 Pages
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Dietary Behavior of Spanish Schoolchildren in Relation to the Polygenic Risk of Obesity

  • Andrea Calderón García,
  • Roberto Pedrero Tomé,
  • Ana Alaminos-Torres,
  • Consuelo Prado Martínez,
  • Jesús Román Martínez Álvarez,
  • Noemí López Ejeda,
  • María Dolores Cabañas Armesilla and
  • María Dolores Marrodán Serrano
Appl. Sci.2023, 13(20), 11169;https://doi.org/10.3390/app132011169

11 October 2023

Several precedents support an association between single nucleotide genetic polymorphisms (SNPs), the obese phenotype, and eating behavior in the infant-juvenile population. This study aims to study this aspect in depth, analyzing the eating behavior...

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  • Open Access
1 Citations
2,009 Views
21 Pages
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Molecular Characteristics and Role of Buffalo SREBF2 in Triglyceride and Cholesterol Biosynthesis in Mammary Epithelial Cells

  • Wenbin Dao,
  • Hongyan Chen,
  • Yina Ouyang,
  • Lige Huang,
  • Xinyang Fan and
  • Yongwang Miao
Genes2025, 16(2), 237;https://doi.org/10.3390/genes16020237

19 February 2025

Background/Objectives: Sterol regulatory element-binding transcription factor 2 (SREBF2) is a key transcription factor involved in regulating cholesterol homeostasis. However, its role in buffalo mammary gland lipid metabolism remains unclear. Method...

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