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Article

320 Views

15 Pages

Superior Diagnostic Yield of EBUS-Guided Cryobiopsy over Needle Aspiration in Isolated, Mass-Negative Mediastinal Lymphadenopathy: A Prospective Within-Patient Study

Nilüfer Yiğit,
Erhan Uğurlu,
Meryem Sanlıalp,
Emel Kılıçarslan,
Ilknur Hatice Akbudak and
Hande Senol

Diagnostics2026, 16(11), 1713;https://doi.org/10.3390/diagnostics16111713

2 June 2026

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the standard minimally invasive technique for mediastinal lymph node sampling; however, its diagnostic performance is limited in diseases requiring preserved...

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Case Report

781 Views

11 Pages

Diagnosis of Microscopic Polyangiitis by EBUS-Guided Transbronchial Mediastinal Cryobiopsy: A Case Report

Miriam Retuerto-Guerrero,
Javier Juan-García,
Pablo Franco-Suárez,
Samuel Saez-Álvarez,
Octavio Miguel Rivero-Lezcano and
Elvira Díez-Álvarez

Diagnostics2026, 16(1), 125;https://doi.org/10.3390/diagnostics16010125

1 January 2026

Background and Clinical Significance: Isolated mediastinal lymphadenopathy is an exceptionally rare and diagnostically challenging initial manifestation of microscopic polyangiitis (MPA), often mimicking malignancy or infection. This case highlights...

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Article

4 Citations

1,412 Views

16 Pages

Transbronchial Mediastinal Cryobiopsy Guided by Endobronchial Ultrasound in Addition to Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in the Diagnosis of Ilo-Mediastinal Lymphadenopathy Without Obvious Primary Lung Neoplastic Lesion: A Prospective Multicenter Study

Francesco Todisco,
Filippo Patrucco,
Aleksandar Veljkovic,
Gian Carlo Vallese,
Davide Indellicati,
Letizia Valsecchi,
Luca Riberi,
Giuseppe Ielo,
Paola Rebecca Iovine and
Massimo Comune
+ 2 authors

J. Clin. Med.2025, 14(20), 7407;https://doi.org/10.3390/jcm14207407

20 October 2025

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) represents the gold standard technique for the diagnosis and staging of lung carcinoma. However, its diagnostic yield may be limited for granulomatous pathologie...

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Review

13 Citations

6,981 Views

10 Pages

A Review of Endobronchial-Ultrasound-Guided Transbronchial Intranodal Forceps Biopsy and Cryobiopsy

Michel Chalhoub,
Bino Joseph and
Sudeep Acharya

Diagnostics2024, 14(9), 965;https://doi.org/10.3390/diagnostics14090965

6 May 2024

Benign and malignant mediastinal lesions are not infrequently encountered in clinical practice. Mediastinoscopy has long been considered the gold standard in evaluating mediastinal pathology. Since its introduction into clinical practice, endobronchi...

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Systematic Review

1 Citations

569 Views

21 Pages

Comparative Efficacy of Transbronchial Needle Aspiration and Cryobiopsies in Thoracic Disorders: A Systematic Review and Meta-Analysis for Optimal Diagnostic Efficacy

Liviu-Ștefan Moacă,
Damiana-Maria Vulturar,
Daniel-Corneliu Leucuța,
Doina Adina Todea,
Teodora-Gabriela Alexescu,
Maria Adriana Neag,
Cezar Aurelian Matau,
Anca Dana Buzoianu and
Claudia Diana Gherman

Life2026, 16(5), 768;https://doi.org/10.3390/life16050768

3 May 2026

This systematic review and meta-analysis evaluate the comparative diagnostic efficacy and safety of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and transbronchial mediastinal cryobiopsy (EBUS-TBMC) for sampling medias...

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