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13 Results Found

  • Article
  • Open Access
12 Citations
3,052 Views
16 Pages

Diterpenoid Alkaloids Isolated from Delphinium brunonianum and Their Inhibitory Effects on Hepatocytes Lipid Accumulation

  • Huanhuan Ma,
  • Yunxia Ma,
  • Zeren Dawa,
  • Yufeng Yao,
  • Meiqi Wang,
  • Kaihui Zhang,
  • Chenchen Zhu,
  • Fangle Liu and
  • Chaozhan Lin

30 March 2022

This research aimed to excavate compounds with activity reducing hepatocytes lipid accumulation from Delphinium brunonianum. Four novel diterpenoid alkaloids, brunodelphinine B–E, were isolated from D. brunonianum together with eleven known dit...

  • Article
  • Open Access
12 Citations
9,911 Views
8 Pages

New Diterpenoid Alkaloids from the Roots of Delphinium tiantaishanense

  • Jie Li,
  • Dong-Lin Chen,
  • Xi-Xian Jian and
  • Feng-Peng Wang

8 March 2007

Four new diterpenoid alkaloids: tiantaishansine (1), tiantaishannine (2), tiantaishanmine (3), and tiantaishandine (4) have been isolated from the roots of Delphinium tiantaishan. Their structures were elucidated by chemical evidence andspectral anal...

  • Article
  • Open Access
5 Citations
3,192 Views
15 Pages

In Vitro and In Silico Investigation of Diterpenoid Alkaloids Isolated from Delphinium chitralense

  • Shujaat Ahmad,
  • Manzoor Ahmad,
  • Mazen Almehmadi,
  • Syed Adnan Ali Shah,
  • Farman Ali Khan,
  • Nasir Mehmood Khan,
  • Asifullah Khan,
  • Zainab,
  • Mustafa Halawi and
  • Hanif Ahmad

This study reports the isolation of three new C20 diterpenoid alkaloids, Chitralinine A–C (1–3) from the aerial parts of Delphinium chitralense. Their structures were established on the basis of latest spectral techniques and single cryst...

  • Article
  • Open Access
10 Citations
4,427 Views
10 Pages

This paper aimed to investigate the potential antifungal influences of new alkaloids from Delphinium peregrinum L. var. eriocarpum Boiss. New Diterpenoid alkaloids Delcarpum (1), Hydrodavisine (4) and known alkaloids Peregrine (2), Delphitisine (3) w...

  • Review
  • Open Access
6 Citations
3,566 Views
24 Pages

12 October 2022

There are famous examples of simple (e.g., hemlock, Conium maculatum L.) and complex (e.g., opium poppy, Papaver somniferum L., Papaveraceae) piperidine-alkaloid-containing plants. Many of these are highly poisonous, whilst pepper is well-known gastr...

  • Review
  • Open Access
60 Citations
8,482 Views
28 Pages

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

  • Amin Mahmood Thawabteh,
  • Alà Thawabteh,
  • Filomena Lelario,
  • Sabino Aurelio Bufo and
  • Laura Scrano

Diterpenoid alkaloids are natural compounds having complex structural features with many stereo-centres originating from the amination of natural tetracyclic diterpenes and produced primarily from plants in the Aconitum, Delphinium, Consolida genera....

  • Review
  • Open Access
4 Citations
1,788 Views
30 Pages

Insecticidal Activities of Diterpene Alkaloids in Plants of the Genera Aconitum and Delphinium

  • Jinqiu Wang,
  • Luchuan Zheng,
  • Wenxi Huang,
  • Linxuan Li,
  • Jialian Yuan and
  • Lin Chen

20 May 2025

As the global population grows, food security and agricultural productivity face challenges, and insect pests cause significant losses to crops. The effectiveness of traditional chemical pesticides is declining, and eco-friendly pesticides need to be...

  • Article
  • Open Access
35 Citations
10,900 Views
14 Pages

31 December 2004

A QSAR toxicity analysis has been performed for a series of 19 alkaloids with the lycoctonine skeleton. GA-MLRA (Genetic Algorithm combined with Multiple Linear Regression Analysis) technique was applied for the generation of two types of QSARs: firs...

  • Review
  • Open Access
48 Citations
7,408 Views
22 Pages

22 June 2019

Diterpenoid alkaloids are isolated from plants of the genera Aconitum, Delphinium, and Garrya (Ranunculaceae) and classified according to their chemical structures as C18-, C19- or C20-diterpenoid alkaloids. The extreme toxicity of certain compounds,...

  • Review
  • Open Access
10 Citations
8,750 Views
19 Pages

Adverse Effects of Larkspur (Delphinium spp.) on Cattle

  • Kevin D. Welch,
  • Daniel Cook,
  • Benedict T. Green,
  • Dale R. Gardner,
  • James A. Pfister,
  • Tara G. McDaneld and
  • Kip E. Panter

There are numerous species of larkspur (Delphinium spp.) in North America. Larkspurs are a major cause of cattle losses on western ranges in the USA, especially on foothill and mountain rangelands. The toxicity of larkspur species is due to various...

  • Review
  • Open Access
20 Citations
5,174 Views
25 Pages

Neuropharmacological Potential of Diterpenoid Alkaloids

  • Arash Salehi,
  • Mustafa Ghanadian,
  • Behzad Zolfaghari,
  • Amir Reza Jassbi,
  • Maryam Fattahian,
  • Parham Reisi,
  • Dezső Csupor,
  • Ikhlas A. Khan and
  • Zulfiqar Ali

This study provides a narrative review of diterpenoid alkaloids (DAs), a family of extremely important natural products found predominantly in some species of Aconitum and Delphinium (Ranunculaceae). DAs have long been a focus of research attention d...

  • Article
  • Open Access
6 Citations
3,427 Views
20 Pages

Synthesis, Pharmacological Evaluation, and Molecular Modeling of Lappaconitine–1,5-Benzodiazepine Hybrids

  • Kirill P. Cheremnykh,
  • Arkadiy O. Bryzgalov,
  • Dmitry S. Baev,
  • Sergey A. Borisov,
  • Yulia S. Sotnikova,
  • Victor A. Savelyev,
  • Tatyana G. Tolstikova,
  • Shamansur S. Sagdullaev and
  • Elvira E. Shults

Diterpenoid alkaloids, originating from the amination of natural tetracyclic diterpenes, have long interested scientists due to their medicinal uses and infamous toxicity which has limited the clinical application of the native compound. Alkaloid lap...

  • Feature Paper
  • Article
  • Open Access
4 Citations
5,248 Views
13 Pages

The Effect of Co-Administration of Death Camas (Zigadenus spp.) and Low Larkspur (Delphinium spp.) in Cattle

  • Kevin D. Welch,
  • Benedict T. Green,
  • Dale R. Gardner,
  • Clinton A. Stonecipher,
  • James A. Pfister and
  • Daniel Cook

12 January 2016

In many rangeland settings, there is more than one potential poisonous plant. Two poisonous plants that are often found growing simultaneously in the same location in North American rangelands are death camas (Zigadenus spp.) and low larkspur (Delphi...