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Article

8 Citations

4,990 Views

11 Pages

Formulation and In Vitro Evaluation of Pellets Containing Sulfasalazine and Caffeine to Verify Ileo-Colonic Drug Delivery

Annemarie Broesder,
Said Y. Bircan,
Anneko B. de Waard,
Anko C. Eissens and ,
Henderik W. Frijlink and
Wouter L. J. Hinrichs
+ 1 author+ 0 author

Pharmaceutics2021, 13(12), 1985;https://doi.org/10.3390/pharmaceutics13121985

23 November 2021

The ColoPulse coating is a pH-dependent coating that can be used to target drug release to the ileo-colonic region. ColoPulse coated tablets and capsules have demonstrated their targeting capabilities in vivo in more than 100 volunteers and patients....

(This article belongs to the Section Biopharmaceutics)

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Article

2,045 Views

15 Pages

Surface Engineering Methods for Powder Bed Printed Tablets to Optimize External Smoothness and Facilitate the Application of Different Coatings

Khanh T. T. Nguyen,
Daan Zillen,
Franca F. M. van Heijningen,
Kjeld J. C. van Bommel and ,
Renz J. van Ee,
Henderik W. Frijlink and
Wouter L. J. Hinrichs
+ 2 authors+ 0 author

Pharmaceutics2023, 15(9), 2193;https://doi.org/10.3390/pharmaceutics15092193

24 August 2023

In a previous attempt to achieve ileo-colonic targeting of bovine intestinal alkaline phosphatase (BIAP), we applied a pH-dependent coating, the ColoPulse coating, directly on powder bed printed (PBP) tablets. However, the high surface roughness nece...

(This article belongs to the Section Pharmaceutical Technology, Manufacturing and Devices)

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Article

14 Citations

5,366 Views

16 Pages

Ileo-Colon Targeting of the Poorly Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in Combination with Self-Emulsifying Drug Delivery or Solid Dispersion Systems

Annemarie Broesder,
Julia M. E. Berends,
Sophie M. Scheepers,
Duong N. Nguyen and ,
Henderik W. Frijlink and
Wouter L. J. Hinrichs
+ 1 author+ 0 author

Pharmaceutics2021, 13(5), 731;https://doi.org/10.3390/pharmaceutics13050731

15 May 2021

Targeting celecoxib to the ileo-colonic region could be beneficial for the treatment and prevention of colon cancer. Ileo-colonic targeting can be achieved by using pH-dependent coating systems such as ColoPulse. Celecoxib has poor aqueous solubility...

(This article belongs to the Special Issue Colon-Targeted Drug Delivery)

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Article

21 Citations

6,437 Views

19 Pages

Towards the Oral Treatment of Ileo-Colonic Inflammatory Bowel Disease with Infliximab Tablets: Development and Validation of the Production Process

Bahez Gareb,
Silke Posthumus,
Max Beugeling,
Pauline Koopmans and ,
Daan J. Touw,
Gerard Dijkstra,
Jos G.W. Kosterink and
Henderik W. Frijlink
+ 3 authors+ 0 author

Pharmaceutics2019, 11(9), 428;https://doi.org/10.3390/pharmaceutics11090428

23 August 2019

Infliximab (IFX) is an intravenously administered monoclonal antibody antagonizing the effects of tumor necrosis factor-alpha (TNF) systemically and is efficacious in the treatment of inflammatory bowel disease (IBD). However, studies suggest that th...

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Article

5 Citations

3,537 Views

20 Pages

Formulation of a 3D Printed Biopharmaceutical: The Development of an Alkaline Phosphatase Containing Tablet with Ileo-Colonic Release Profile to Treat Ulcerative Colitis

Khanh T. T. Nguyen,
Franca F. M. Heijningen,
Daan Zillen,
Kjeld J. C. van Bommel and ,
Renz J. van Ee,
Henderik W. Frijlink and
Wouter L. J. Hinrichs
+ 2 authors+ 0 author

Pharmaceutics2022, 14(10), 2179;https://doi.org/10.3390/pharmaceutics14102179

13 October 2022

Powder bed printing is a 3D-printing process that creates freeform geometries from powders, with increasing traction for personalized medicine potential. Little is known about its applications for biopharmaceuticals. In this study, the production of...

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