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14 pages, 590 KiB  
Article
Color-Dependent Polymerization: The Impact of Curing Time on the Conversion Degree and Microhardness of Colored Compomers
by Ozgul Carti Dorterler, Fatma Yilmaz and Ozge Tokul Olmez
Polymers 2025, 17(15), 2155; https://doi.org/10.3390/polym17152155 - 6 Aug 2025
Abstract
This study investigated the effects of color shade and curing time on the degree of conversion (DC) and microhardness of colored compomers. A total of 162 samples (81 for DC, 81 for microhardness) were prepared, with nine samples per color group (gold, blackberry, [...] Read more.
This study investigated the effects of color shade and curing time on the degree of conversion (DC) and microhardness of colored compomers. A total of 162 samples (81 for DC, 81 for microhardness) were prepared, with nine samples per color group (gold, blackberry, green, pink, orange, lemon, blue, silver) and for the control. Samples were subdivided into three polymerization subgroups (3 s/3200 mW/cm2, 10 s/1000 mW/cm2, 20 s/1000 mW/cm2). The DC was analyzed via fourier transform infrared spectroscopy (FTIR) and microhardness was measured using Vickers testing. Statistical analysis included two-way ANOVA and Spearman correlation (α = 0.05). The colored compomers demonstrated a significantly lower DC compared to the control group (p ≤ 0.001). Among the tested colors, green exhibited the lowest DC (33.3%), while orange showed the highest (51.0%). A significant difference in DC was observed across curing times (p = 0.005), with the 3 s and 20 s groups exhibiting significantly higher conversion rates than the 10 s group. Microhardness values exhibited significant variation depending on the color (p < 0.001). Gold compomers demonstrated the lowest microhardness, whereas silver compomers showed comparable performance with the control group (p = 0.154). A moderate correlation between DC and microhardness was observed overall (ρ = 0.42, p = 0.003). However, the observed relationships were color-dependent: orange displayed a strong positive correlation (ρ = 0.78), whereas pink revealed no meaningful association (ρ = −0.15). Color and curing time critically influence compomer performance. High-intensity short curing is viable for lighter colors, while darker colors require extended curing. Customized protocols are essential to optimize clinical outcomes in pediatric dentistry. Full article
(This article belongs to the Section Polymer Analysis and Characterization)
17 pages, 1800 KiB  
Article
Healing Kinetics of Sinus Lift Augmentation Using Biphasic Calcium Phosphate Granules: A Case Series in Humans
by Michele Furlani, Valentina Notarstefano, Nicole Riberti, Emira D’Amico, Tania Vanessa Pierfelice, Carlo Mangano, Elisabetta Giorgini, Giovanna Iezzi and Alessandra Giuliani
Bioengineering 2025, 12(8), 848; https://doi.org/10.3390/bioengineering12080848 (registering DOI) - 6 Aug 2025
Abstract
Sinus augmentation provides a well-established model for investigating the three-dimensional morphometry and macromolecular dynamics of bone regeneration, particularly when using biphasic calcium phosphate (BCP) graft substitutes. This case series included six biopsies from patients who underwent maxillary sinus augmentation using BCP granules composed [...] Read more.
Sinus augmentation provides a well-established model for investigating the three-dimensional morphometry and macromolecular dynamics of bone regeneration, particularly when using biphasic calcium phosphate (BCP) graft substitutes. This case series included six biopsies from patients who underwent maxillary sinus augmentation using BCP granules composed of 30% hydroxyapatite (HA) and 70% β-tricalcium phosphate (β-TCP). Bone core biopsies were obtained at healing times of 6 months, 9 months, and 12 months. Histological evaluation yielded qualitative and quantitative insights into new bone distribution, while micro-computed tomography (micro-CT) and Raman microspectroscopy (RMS) were employed to assess the three-dimensional architecture and macromolecular composition of the regenerated bone. Micro-CT analysis revealed progressive maturation of the regenerated bone microstructure over time. At 6 months, the apical regenerated area exhibited a significantly higher mineralized volume fraction (58 ± 5%) compared to the basal native bone (44 ± 11%; p = 0.0170), as well as significantly reduced trabecular spacing (Tb.Sp: 187 ± 70 µm vs. 325 ± 96 µm; p = 0.0155) and degree of anisotropy (DA: 0.37 ± 0.05 vs. 0.73 ± 0.03; p < 0.0001). By 12 months, the mineralized volume fraction in the regenerated area (53 ± 5%) was statistically comparable to basal bone (44 ± 3%; p > 0.05), while Tb.Sp (211 ± 20 µm) and DA (0.23 ± 0.09) remained significantly lower (Tb.Sp: 395 ± 41 µm, p = 0.0041; DA: 0.46 ± 0.04, p = 0.0001), indicating continued structural remodelling and organization. Raman microspectroscopy further revealed dynamic macromolecular changes during healing. Characteristic β-TCP peaks (e.g., 1315, 1380, 1483 cm−1) progressively diminished over time and were completely absent in the regenerated tissue at 12 months, contrasting with their partial presence at 6 months. Simultaneously, increased intensity of collagen-specific bands (e.g., Amide I at 1661 cm−1, Amide III at 1250 cm−1) and carbonate peaks (1065 cm−1) reflected active matrix formation and mineralization. Overall, this case series provides qualitative and quantitative evidence that bone regeneration and integration of BCP granules in sinus augmentation continues beyond 6 months, with ongoing maturation observed up to 12 months post-grafting. Full article
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12 pages, 398 KiB  
Article
Comparison of Microhardness and Depth of Cure of Six Bulk-Fill Resin Composites
by Tomislav Skrinjaric, Kristina Gorseta, Jelena Bagaric, Petra Bucevic Sojcic, Jakov Stojanovic and Luc A. M. Marks
J. Compos. Sci. 2025, 9(8), 418; https://doi.org/10.3390/jcs9080418 - 5 Aug 2025
Abstract
Background. Physicomechanical properties and clinical service of bulk-fill composites depend on their adequate polymerization and depth of cure. Some manufacturers claim that these composites can be adequately cured when used in bulks exceeding 4 mm. Objective. The aim of this study was to [...] Read more.
Background. Physicomechanical properties and clinical service of bulk-fill composites depend on their adequate polymerization and depth of cure. Some manufacturers claim that these composites can be adequately cured when used in bulks exceeding 4 mm. Objective. The aim of this study was to compare Vickers microhardness (VMH) and depth of cure (DOC) of six contemporary bulk-fill resin composites at depths of 4 mm and 6 mm. Material and methods. Six bulk-fill composites were evaluated in this study: 1. Tetric EvoCeram Bulk (Ivoclar Vivadent, Schaan, Liechtenstein), (TEC); 2. Filtek Bulk Fill Posterior (3M ESPE Dental Products Division, St. Paul, MN, USA), (FBF); 3. Filtek One Bulk Fill (3M ESPE Dental Products Division, St. Paul, MN, USA, (FOB); 4. SonicFill 2 (Kerr, Orange, CA, USA), (SF2); 5. Admira Fusion X-tra (Voco, GmbH, Cuxhaven, Germany), (AFX); 6. GrandioSO X-tra (Voco, GmbH, Cuxhaven, Germany), (GSX). The 18 specimens (3 of each composite) were prepared in split Teflon moulds of 4 mm diameter and 6 mm thickness. All composites were cured in standard mode for 20 s using LED LCU (D-Light Duo, RF-Pharmaceuticals Sarl, Geneva, Switzerland; 1200–1300 mW/cm). The VMH was measured using a digital Micro Hardness Tester Shimadzu (HMV-2T E, Shimadzu Corporation, Kyoto, Japan). A 50 g (0.5 N) load force was applied for 30 s. Each specimen was measured at five places selected by chance at each level (N = 15). The hardness ratio or DOC was calculated for all samples as the ratio of bottom and surface microhardness at levels of 4 and 6 mm. Data were analysed using one-way ANOVA and Tukey’s post hoc test. Results. Significant reduction in VMH was observed for all tested materials when comparing top surface and bottom (p < 0.01). The highest VMH was obtained for GSX and AFX, and the lowest for TEC. The results show that the degree of polymerization was adequate for all tested materials at a depth of 6 mm, since the hardness ratio exceeded 0.80 in all cases. The hardness ratio at 4 mm was high for all tested composites ranging from 0.91 for TEC to 0.98 for GSX. All composites showed adequate DOC at the bottom of the 6 mm bulk samples. However, the hardness ratio was the highest for Admira Fusion X-tra (0.96) and GrandioSO X-tra (0.97). Conclusions. All tested materials showed a significant decrease in microhardness from the top surface to the bottom. The DOC was adequate for all bulk-fill composites at a depth of 6 mm cured under standard mode for 20 s. All bulk-fill resin composites evaluated in this study can be used in bulk, up to 6 mm. Full article
(This article belongs to the Special Issue Innovations in Direct and Indirect Dental Composite Restorations)
10 pages, 615 KiB  
Article
Translating SGRT from Breast to Lung Cancer: A Study on Frameless Immobilization and Real-Time Monitoring Efficacy, Focusing on Setup Accuracy
by Jang Bo Shim, Hakyoung Kim, Sun Myung Kim and Dae Sik Yang
Life 2025, 15(8), 1234; https://doi.org/10.3390/life15081234 - 4 Aug 2025
Viewed by 75
Abstract
Objectives: Surface-Guided Radiation Therapy (SGRT) has been widely adopted in breast cancer radiotherapy, particularly for improving setup accuracy and motion management. Recently, its application in lung cancer has attracted growing interest due to similar needs for precision. This study investigates the feasibility and [...] Read more.
Objectives: Surface-Guided Radiation Therapy (SGRT) has been widely adopted in breast cancer radiotherapy, particularly for improving setup accuracy and motion management. Recently, its application in lung cancer has attracted growing interest due to similar needs for precision. This study investigates the feasibility and clinical utility of SGRT in lung cancer treatment, focusing on its effectiveness in patient setup and real-time motion monitoring under frameless immobilization conditions. Materials and Methods: A total of 204 treatment records from 17 patients with primary lung cancer who underwent radiotherapy at Korea University Guro Hospital between October 2024 and April 2025 were retrospectively analyzed. Patients were initially positioned using the Identify system (Varian) in the CT suite, with surface data transferred to the treatment room system. Alignment was performed to within ±1 cm and ±2° across six degrees of freedom. Cone-beam CT (CBCT) was acquired prior to treatment for verification, and treatment commenced when the Distance to Correspondence Surface (DCS) was ≤0.90. Setup deviations from the Identify system were recorded and compared with CBCT in three translational axes to evaluate positioning accuracy and PTV displacement. Results and Conclusions: The Identify system was shown to provide high setup accuracy and reliable real-time motion monitoring in lung cancer radiotherapy. Its ability to detect patient movement and automatically interrupt beam delivery contributes to enhanced treatment safety and precision. In addition, even though the maximum longitudinal (Lng) shift reached up to −1.83 cm with surface-guided setup, and up to 1.78 cm (Lat) 5.26 cm (Lng), 9.16 cm (Vrt) with CBCT-based verification, the use of Identify’s auto-interruption mode (±1 cm in translational axes, ±2° in rotational axes) allowed treatment delivery with PTV motion constrained within ±0.02 cm. These results suggest that, due to significant motion in the longitudinal direction, appropriate PTV margins should be considered during treatment planning. The Identify system enhances setup accuracy in lung cancer patients using a surface-guided approach and enables real-time tracking of intra-fractional errors. SGRT, when implemented with systems such as Identify, shows promise as a feasible alternative or complement to conventional IGRT in selected lung cancer cases. Further studies with larger patient cohorts and diverse clinical settings are warranted to validate these findings. Full article
(This article belongs to the Special Issue Current Advances in Lung Cancer Diagnosis and Treatment)
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19 pages, 6111 KiB  
Article
Impact of Water Conductivity on the Structure and Swelling Dynamics of E-Beam Cross-Linked Hydrogels
by Elena Mănăilă, Ion Călina, Anca Scărișoreanu, Maria Demeter, Gabriela Crăciun and Marius Dumitru
Gels 2025, 11(8), 611; https://doi.org/10.3390/gels11080611 - 4 Aug 2025
Viewed by 154
Abstract
Prolonged drought and soil degradation severely affect soil fertility and limit crop productivity. Superabsorbent hydrogels offer an effective solution for improving water retention in soil and supporting plant growth. In this work, we examined the performance of superabsorbent hydrogels based on sodium alginate, [...] Read more.
Prolonged drought and soil degradation severely affect soil fertility and limit crop productivity. Superabsorbent hydrogels offer an effective solution for improving water retention in soil and supporting plant growth. In this work, we examined the performance of superabsorbent hydrogels based on sodium alginate, acrylic acid (AA), and poly (ethylene oxide) (PEO) cross-linked with 12.5 kGy using e-beam irradiation. The hydrogels were assessed in various aqueous environments by examining network characteristics, swelling capacity, and swelling kinetics to evaluate the impact of water’s electrical conductivity (which ranges from 0.05 to 321 μS/cm). Morphological and chemical structure changes were evaluated using SEM and FTIR techniques. The results demonstrated that water conductivity significantly affected the physicochemical properties of the hydrogels. Swelling behavior showed notable sensitivity to electrical conductivity variations, with swelling degrees reaching 28,400% at 5 μS/cm and 14,000% at 321 μS/cm, following first-order and second-order kinetics. FTIR analysis confirmed that structural modifications correlated with water conductivity, particularly affecting the O–H, C–H, and COOH groups sensitive to the ionic environment. SEM characterization revealed a porous morphology with an interconnected microporous network that facilitates efficient water diffusion. These hydrogels show exceptional swelling capacity and are promising candidates for sustainable agriculture applications. Full article
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19 pages, 977 KiB  
Article
Physical-Hydric Properties of a Planosols Under Long-Term Integrated Crop–Livestock–Forest System in the Brazilian Semiarid
by Valter Silva Ferreira, Flávio Pereira de Oliveira, Pedro Luan Ferreira da Silva, Adriana Ferreira Martins, Walter Esfrain Pereira, Djail Santos, Tancredo Augusto Feitosa de Souza, Robson Vinício dos Santos and Milton César Costa Campos
Forests 2025, 16(8), 1261; https://doi.org/10.3390/f16081261 - 2 Aug 2025
Viewed by 159
Abstract
The objective of this study was to evaluate the physical-hydric properties of a Planosol under an Integrated Crop–Livestock–Forest (ICLF) system in the Agreste region of Paraíba, Brazil, after eight years of implementation, and to compare them with areas under a conventional cropping system [...] Read more.
The objective of this study was to evaluate the physical-hydric properties of a Planosol under an Integrated Crop–Livestock–Forest (ICLF) system in the Agreste region of Paraíba, Brazil, after eight years of implementation, and to compare them with areas under a conventional cropping system and secondary native vegetation. The experiment was conducted at the experimental station located in Alagoinha, in the Agreste mesoregion of the State of Paraíba, Brazil. The experimental design adopted was a randomized block design (RBD) with five treatments and four replications (5 × 4 + 2). The treatments consisted of: (1) Gliricidia (Gliricidia sepium (Jacq.) Steud) + Signal grass (Urochloa decumbens) (GL+SG); (2) Sabiá (Mimosa caesalpiniaefolia Benth) + Signal grass (SB+SG); (3) Purple Ipê (Handroanthus avellanedae (Lorentz ex Griseb.) Mattos) + SG (I+SG); (4) annual crop + SG (C+SG); and (5) Signal grass (SG). Two additional treatments were included for statistical comparison: a conventional cropping system (CC) and a secondary native vegetation area (NV), both located near the experimental site. The CC treatment showed the lowest bulk density (1.23 g cm−3) and the lowest degree of compaction (66.3%) among the evaluated treatments, as well as a total porosity (TP) higher than 75% (0.75 m3 m−3). In the soil under the integration system, the lowest bulk density (1.38 g cm−3) and the highest total porosity (0.48 m3 m−3) were observed in the SG treatment at the 0.0–0.10 m depth. High S-index values (>0.035) and a low relative field capacity (RFc < 0.50) and Kθ indicate high structural quality and low soil water storage capacity. It was concluded that the SG, I+SG, SB+SG, and CC treatments presented the highest values of soil bulk and degree of compaction in the layers below 0.10 m. The I+SG and C+SG treatments showed the lowest hydraulic conductivities and macroaggregation. The SG and C+SG treatments had the lowest available water content and available water capacity across the three analyzed soil layers. Full article
(This article belongs to the Special Issue Forest Soil Physical, Chemical, and Biological Properties)
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20 pages, 7211 KiB  
Article
Experimental and Numerical Analysis of Corrosion-Induced Cracking in Reinforced Concrete
by Olfa Loukil, Lucas Adelaide, Veronique Bouteiller and Marc Quiertant
Appl. Mech. 2025, 6(3), 57; https://doi.org/10.3390/applmech6030057 - 1 Aug 2025
Viewed by 167
Abstract
The aim of this paper is to present the results of an experimental and numerical investigation into the degradation of reinforced concrete (RC) specimens subjected to an accelerated corrosion process using impressed current in the presence of chloride ions. The corrosion of the [...] Read more.
The aim of this paper is to present the results of an experimental and numerical investigation into the degradation of reinforced concrete (RC) specimens subjected to an accelerated corrosion process using impressed current in the presence of chloride ions. The corrosion of the rebars was carried out using three current densities (50, 100, and 200 µA/cm2) and various exposure times. The experimental results characterised the internal degradation of the RC specimens through measurement of the corrosion product thicknesses at the steel–concrete interface; the widths, lengths and orientations of internal concrete cracks; and the external concrete crack widths. In addition, numerical modelling of the corroded RC specimens was conducted to describe the crack patterns. The comparison between the experimental and numerical results demonstrated a high degree of correlation, providing insights into the degradation process of RC specimens due to corrosion. Full article
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15 pages, 8138 KiB  
Article
Study on the Characteristics of Straw Fiber Curtains for Protecting Embankment Slopes from Rainfall Erosion
by Xiangyong Zhong, Feng Xu, Rusong Nie, Yang Li, Chunyan Zhao and Long Zhang
Eng 2025, 6(8), 179; https://doi.org/10.3390/eng6080179 - 1 Aug 2025
Viewed by 125
Abstract
Straw fiber curtain contains a plant fiber blanket woven from crop straw, which is mainly used to protect embankment slopes from rainwater erosion. To investigate the erosion control performance of slopes covered with straw fiber curtains of different structural configurations, physical model tests [...] Read more.
Straw fiber curtain contains a plant fiber blanket woven from crop straw, which is mainly used to protect embankment slopes from rainwater erosion. To investigate the erosion control performance of slopes covered with straw fiber curtains of different structural configurations, physical model tests were conducted in a 95 cm × 65 cm × 50 cm (length × height × width) test box with a slope ratio of 1:1.5 under controlled artificial rainfall conditions (20 mm/h, 40 mm/h, and 60 mm/h). The study evaluated the runoff characteristics, sediment yield, and key hydrodynamic parameters of slopes under the coverage of different straw fiber curtain types. The results show that the A-type straw fiber curtain (woven with strips of straw fiber) has the best effect on water retention and sediment reduction, while the B-type straw fiber curtain (woven with thicker straw strips) with vertical straw fiber has a better effect regarding water retention and sediment reduction than the B-type transverse straw fiber curtain. The flow of rainwater on a slope covered with straw fiber curtain is mainly a laminar flow. Straw fiber curtain can promote the conversion of water flow from rapids to slow flow. The Darcy-Weisbach resistance coefficient of straw fiber curtain increases at different degrees with an increase in rainfall time. Full article
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15 pages, 3303 KiB  
Article
Effect of Ozone on Nonwoven Polylactide/Natural Rubber Fibers
by Yulia V. Tertyshnaya, Svetlana G. Karpova and Maria V. Podzorova
Polymers 2025, 17(15), 2102; https://doi.org/10.3390/polym17152102 - 31 Jul 2025
Viewed by 140
Abstract
Ozone is a powerful destructive agent in the oxidative process of polymer composites. The destructive ability of ozone depends primarily on its concentration, duration of exposure, the type of polymer, and its matrix structure. In this work, nonwoven PLA/NR fibers with natural rubber [...] Read more.
Ozone is a powerful destructive agent in the oxidative process of polymer composites. The destructive ability of ozone depends primarily on its concentration, duration of exposure, the type of polymer, and its matrix structure. In this work, nonwoven PLA/NR fibers with natural rubber contents of 5, 10, and 15 wt.% were obtained, which were then subjected to ozone oxidation for 800 min. The effect of ozone treatment was estimated using various methods of physicochemical analysis. The visual effect was manifested in the form of a change in the color of PLA/NR fibers. The method of differential scanning calorimetry revealed a change in the thermophysical characteristics. The glass transition and cold crystallization temperatures of polylactide shifted toward lower temperatures, and the degree of crystallinity increased. It was found that in PLA/NR fiber samples, the degradation process predominates over the crosslinking process, as an increase in the melt flow rate by 1.5–1.6 times and a decrease in the correlation time determined by the electron paramagnetic resonance method were observed. The IR Fourier method recorded a change in the chemical structure during ozone oxidation. The intensity of the ether bond bands changed, and new bands appeared at 1640 and 1537 cm−1, which corresponded to the formation of –C=C– bonds. Full article
(This article belongs to the Special Issue Natural Degradation of Polymers)
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21 pages, 3748 KiB  
Article
Synthesis of Jicama (Pachyrhizus erosus) Starch Particles by Electrospraying: Effect of the Hydrolysis Degree
by Fatima Sarahi Serrano-Villa, Eduardo Morales-Sánchez, José Alfredo Téllez-Morales, Verónica Cuellar-Sánchez, Reynold R. Farrera-Rebollo and Georgina Calderón-Domínguez
Polymers 2025, 17(15), 2069; https://doi.org/10.3390/polym17152069 - 29 Jul 2025
Viewed by 336
Abstract
Electrohydrodynamic atomization (EHDA) has significant advantages for microencapsulating compounds in various structures using biopolymers, where more research using pure starch is required. Concerning this, jicama starch and its hydrolysates have not yet been tested, despite their unique characteristics, which come from an alternative [...] Read more.
Electrohydrodynamic atomization (EHDA) has significant advantages for microencapsulating compounds in various structures using biopolymers, where more research using pure starch is required. Concerning this, jicama starch and its hydrolysates have not yet been tested, despite their unique characteristics, which come from an alternative low-value-added crop source. Rapid acid hydrolysis of jicama starch with H2SO4 resulted in dextrins with a degree of hydrolysis (DE) from 0.4 to 19% within 1–12 h, and syrup solids at 24 h (DE = 42%). This process modifies the water retention capacity of jicama starch, gel viscosity, surface tension, and electrical conductivity. Hydrolyzed starch particles obtained by electrospraying (10 kV, L = 10 cm, Q = 2 mL/h) showed Feret diameters and roundness significantly influenced (p ≤ 0.05) by the degree of hydrolysis rather than the concentration of solids. It was found that hydrolyzed jicama starch with a DE < 6.3% can be used as the sole wall material to form particles by electrospraying, as they facilitate the formation of stable and rounded like-microspheres particles; this was not feasible above this threshold. The results suggest that the jicama starch’s ability to be used as a wall material in the electrospray synthesis of particles or microspheres appears to be determined by the degree of hydrolysis. Full article
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9 pages, 1013 KiB  
Article
Continuous Radiofrequency for Morton’s Neuroma: Is There Complete Ablation? A Preliminary Report
by Gabriel Camuñas-Nieves, Alejandro Fernández-Gibello, Simone Moroni, Felice Galluccio, Mario Fajardo-Pérez, Francisco Martínez-Pérez, Eduardo Simón-Pérez and Alfonso Martínez-Nova
Healthcare 2025, 13(15), 1838; https://doi.org/10.3390/healthcare13151838 - 28 Jul 2025
Viewed by 371
Abstract
Background and Objectives: Morton’s neuroma is a painful foot condition that can be treated with continuous radiofrequency. However, its efficacy is not always optimal, with failure rates of 15–20%. It has been suggested that these failures may be due to incomplete nerve ablation, [...] Read more.
Background and Objectives: Morton’s neuroma is a painful foot condition that can be treated with continuous radiofrequency. However, its efficacy is not always optimal, with failure rates of 15–20%. It has been suggested that these failures may be due to incomplete nerve ablation, allowing for nerve regeneration and persistent pain. So, the aim of this study was to assess the histological effects of continuous radiofrequency on the nerves affected by Morton’s neuroma. Materials and Methods: The effect of continuous radiofrequency was evaluated in two patients with Morton’s neuroma, which required open surgery excision. In both cases, radiofrequency with a standard protocol was applied ex vivo, following the surgical excision of the neuroma. A TLG10 RF generator (90 °C, 90 s) with a monopolar needle with a 0.5 cm active tip was used. Subsequently, the samples were histologically analyzed to determine the degree of nerve ablation. Results: Histological analysis showed homogeneous focal necrosis in both cases, with lesion depths of 2.4 mm and 3.18 mm. However, areas of intact nerve tissue were identified at the periphery of the neuroma, suggesting incomplete ablation. Conclusions: The findings indicate that continuous radiofrequency does not guarantee total nerve ablation, which could explain recurrence in some cases. Intraoperative neurophysiological monitoring could be key to optimizing the procedure, ensuring complete interruption of nerve conduction and improving treatment efficacy. Full article
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21 pages, 14138 KiB  
Case Report
Multi-Level Oncological Management of a Rare, Combined Mediastinal Tumor: A Case Report
by Vasileios Theocharidis, Thomas Rallis, Apostolos Gogakos, Dimitrios Paliouras, Achilleas Lazopoulos, Meropi Koutourini, Myrto Tzinevi, Aikaterini Vildiridi, Prokopios Dimopoulos, Dimitrios Kasarakis, Panagiotis Kousidis, Anastasia Nikolaidou, Paraskevas Vrochidis, Maria Mironidou-Tzouveleki and Nikolaos Barbetakis
Curr. Oncol. 2025, 32(8), 423; https://doi.org/10.3390/curroncol32080423 - 28 Jul 2025
Viewed by 444
Abstract
Malignant mediastinal tumors are a group representing some of the most demanding oncological challenges for early, multi-level, and successful management. The timely identification of any suspicious clinical symptomatology is urgent in achieving an accurate, staged histological diagnosis, in order to follow up with [...] Read more.
Malignant mediastinal tumors are a group representing some of the most demanding oncological challenges for early, multi-level, and successful management. The timely identification of any suspicious clinical symptomatology is urgent in achieving an accurate, staged histological diagnosis, in order to follow up with an equally detailed medical therapeutic plan (interventional or not) and determine the principal goals regarding efficient overall treatment in these patients. We report a case of a 24-year-old male patient with an incident-free prior medical history. An initial chest X-ray was performed after the patient reported short-term, consistent moderate chest pain symptomatology, early work fatigue, and shortness of breath. The following imaging procedures (chest CT, PET-CT) indicated the presence of an anterior mediastinal mass (meas. ~11 cm × 10 cm × 13 cm, SUV: 8.7), applying additional pressure upon both right heart chambers. The Alpha-Fetoprotein (aFP) blood levels had exceeded at least 50 times their normal range. Two consecutive diagnostic attempts with non-specific histological results, a negative-for-malignancy fine-needle aspiration biopsy (FNA-biopsy), and an additional tumor biopsy, performed via mini anterior (R) thoracotomy with “suspicious” cellular gatherings, were performed elsewhere. After admission to our department, an (R) Video-Assisted Thoracic Surgery (VATS) was performed, along with multiple tumor biopsies and moderate pleural effusion drainage. The tumor’s measurements had increased to DMax: 16 cm × 9 cm × 13 cm, with a severe degree of atelectasis of the Right Lower Lobe parenchyma (RLL) and a pressure-displacement effect upon the Superior Vena Cava (SVC) and the (R) heart sinus, based on data from the preoperative chest MRA. The histological report indicated elements of a combined, non-seminomatous germ-cell mediastinal tumor, posthuberal-type teratoma, and embryonal carcinoma. The imminent chemotherapeutic plan included a “BEP” (Bleomycin®/Cisplatin®/Etoposide®) scheme, which needed to be modified to a “VIP” (Cisplatin®/Etoposide®/Ifosfamide®) scheme, due to an acute pulmonary embolism incident. While the aFP blood levels declined, even reaching normal measurements, the tumor’s size continued to increase significantly (DMax: 28 cm × 25 cm × 13 cm), with severe localized pressure effects, rapid weight loss, and a progressively worsening clinical status. Thus, an emergency surgical intervention took place via median sternotomy, extended with a complementary “T-Shaped” mini anterior (R) thoracotomy. A large, approx. 4 Kg mediastinal tumor was extracted, with additional RML and RUL “en-bloc” segmentectomy and partial mediastinal pleura decortication. The following histological results, apart from verifying the already-known posthuberal-type teratoma, indicated additional scattered small lesions of combined high-grade rabdomyosarcoma, chondrosarcoma, and osteosarcoma, as well as numerous high-grade glioblastoma cellular gatherings. No visible findings of the previously discovered non-seminomatous germ-cell and embryonal carcinoma elements were found. The patient’s postoperative status progressively improved, allowing therapeutic management to continue with six “TIP” (Cisplatin®/Paclitaxel®/Ifosfamide®) sessions, currently under his regular “follow-up” from the oncological team. This report underlines the importance of early, accurate histological identification, combined with any necessary surgical intervention, diagnostic or therapeutic, as well as the appliance of any subsequent multimodality management plan. The diversity of mediastinal tumors, especially for young patients, leaves no place for complacency. Such rare examples may manifest, with equivalent, unpredictable evolution, obliging clinical physicians to stay constantly alert and not take anything for granted. Full article
(This article belongs to the Section Thoracic Oncology)
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27 pages, 4829 KiB  
Article
Quantitative Analysis of Ginger Maturity and Pulsed Electric Field Thresholds: Effects on Microstructure and Juice’s Nutritional Profile
by Zhong Han, Pan He, Yu-Huan Geng, Muhammad Faisal Manzoor, Xin-An Zeng, Suqlain Hassan and Muhammad Talha Afraz
Foods 2025, 14(15), 2637; https://doi.org/10.3390/foods14152637 - 28 Jul 2025
Viewed by 416
Abstract
This study used fresh (young) and old (mature) ginger tissues as model systems to investigate how plant maturity modulates the response to pulsed electric field (PEF), a non-thermal processing technology. Specifically, the influence of tissue maturity on dielectric behavior and its downstream effect [...] Read more.
This study used fresh (young) and old (mature) ginger tissues as model systems to investigate how plant maturity modulates the response to pulsed electric field (PEF), a non-thermal processing technology. Specifically, the influence of tissue maturity on dielectric behavior and its downstream effect on juice yield and bioactive compound extraction was systematically evaluated. At 2.5 kV/cm, old ginger exhibited a pronounced dielectric breakdown effect due to enhanced electrolyte content and cell wall lignification, resulting in a higher degree of cell disintegration (0.65) compared with fresh ginger (0.44). This translated into a significantly improved juice yield of 90.85% for old ginger, surpassing the 84.16% limit observed in fresh ginger. HPLC analysis revealed that the extraction efficiency of 6-gingerol and 6-shogaol increased from 1739.16 to 2233.60 µg/g and 310.31 to 339.63 µg/g, respectively, in old ginger after PEF treatment, while fresh ginger showed increases from 1257.88 to 1824.05 µg/g and 166.43 to 213.52 µg/g, respectively. Total phenolic content (TPC) and total flavonoid content (TFC) also increased in both tissues, with OG-2.5 reaching 789.57 µg GAE/mL and 336.49 µg RE/mL, compared with 738.19 µg GAE/mL and 329.62 µg RE/mL in FG-2.5. Antioxidant capacity, as measured by ABTS•+ and DPPH inhibition, improved more markedly in OG-2.5 (37.8% and 18.7%, respectively) than in FG-2.5. Moreover, volatile compound concentrations increased by 177.9% in OG-2.5 and 137.0% in FG-2.5 compared with their respective controls, indicating differential aroma intensification and compound transformation. Structural characterization by SEM and FT-IR further corroborated enhanced cellular disruption and biochemical release in mature tissue. Collectively, these results reveal a maturity-dependent mechanism of electro-permeabilization in plant tissues, offering new insights into optimizing non-thermal processing for functional food production. Full article
(This article belongs to the Section Food Engineering and Technology)
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17 pages, 4007 KiB  
Article
Variations in Soil Salt Ions and Salinization Degree in Shallow Groundwater Areas During the Freeze–Thaw Period
by Chao Han, Qiang Meng, Junfeng Chen, Lihong Cui, Jing Xue, Hongwu Liu and Rong Yan
Water 2025, 17(15), 2234; https://doi.org/10.3390/w17152234 - 26 Jul 2025
Viewed by 479
Abstract
In shallow groundwater areas, the freeze–thaw process can easily exacerbate soil salinization. The variations and migrations of Na+, K+, Ca2+, Mg2+, Cl, SO42−, and HCO3 at the depth [...] Read more.
In shallow groundwater areas, the freeze–thaw process can easily exacerbate soil salinization. The variations and migrations of Na+, K+, Ca2+, Mg2+, Cl, SO42−, and HCO3 at the depth of 0–100 cm under shallow groundwater depth (2.63–2.87 m) during the freeze–thaw period were analyzed. And a multi-index comprehensive evaluation method based on factor analysis was employed to investigate the soil salinization degree. The results show that K+, Mg2+, and HCO3 exhibited surface enrichment during the freeze–thaw period, while Na+, Cl, and SO42− accumulated in the frozen layer during the freezing stage. However, there is no surface enrichment of Ca2+. During the freezing stage, Mg2+ and Cl exhibited the strongest migration capabilities among cations and anions, respectively. During the thawing stage, K+ and HCO3 were the cation and anion with the highest ionic migration capabilities, respectively. Total salinity (TS), Cl, SO42−, HCO3, Na+, K+, Mg2+, and residual sodium carbonate (RSC) were identified as the dominant factors influencing the salinization degree during the freeze–thaw period. During the freezing stage, soil salt ions predominantly migrated from the unfrozen to the frozen layer, and the salinization degree in the frozen layer increased with the development of the frozen layer. In the thawing stage, soil salt ions migrated upward from the thawing front, and the salinization degree at the depth of 0–30 cm increased. This study provides insights for the prevention and control of soil salinization in arid regions. Full article
(This article belongs to the Special Issue Advances in Soil Water Dynamics Research)
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26 pages, 3318 KiB  
Article
Responses of Tomato Growth and Soil Environment Properties to Integrated Deficit Water-Biogas Slurry Application Under Indirect Subsurface Drip Irrigation
by Peng Xiang, Jian Zheng, Panpan Fan, Yan Wang and Fenyan Ma
Agriculture 2025, 15(15), 1601; https://doi.org/10.3390/agriculture15151601 - 25 Jul 2025
Viewed by 315
Abstract
To explore the feasibility of integrated deficit water-biogas slurry irrigation under indirect subsurface drip irrigation, three deficit irrigation levels (60%FC, 70%FC, and 80%FC; FC represents field capacity) were established during the three growth stages of tomatoes. The results indicated that biogas slurry irrigation [...] Read more.
To explore the feasibility of integrated deficit water-biogas slurry irrigation under indirect subsurface drip irrigation, three deficit irrigation levels (60%FC, 70%FC, and 80%FC; FC represents field capacity) were established during the three growth stages of tomatoes. The results indicated that biogas slurry irrigation treatments increased the soil organic matter content in the root zone and water use efficiency (WUE) and reduced soil pH. As the degree of deficit increased, the plant height and stem diameter of tomatoes decreased significantly (p < 0.05), particularly during the seedling and flowering-fruiting stages. A mild deficit during the seedling stage was beneficial for subsequent plant growth, yielding maximum leaf area (6871.42 cm2 plant−1). Moderate deficit treatment at the seedling stage maximized yield, which was 19.79% higher than the control treatment in 2020 and 19.22% higher in 2021. The WUE of severe deficit treatment at the maturity stage increased by 26.6% (2020) and 31.04% (2021) compared to the control treatment. Comprehensive evaluation using TOPSIS combined with the weighted method revealed that severe deficit treatment at the maturity stage provided the best comprehensive benefits for tomatoes. In summary, deficit irrigation at different growth stages positively influenced tomato growth, quality, and soil environment in response to water-biogas slurry irrigation. Full article
(This article belongs to the Section Agricultural Water Management)
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