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Case Report

23 Citations

16,096 Views

7 Pages

Cocaine-Induced Midline Destructive Lesions (CIMDL): A Real Challenge in Diagnosis

Michele Di Cosola,
Mariateresa Ambrosino,
Luisa Limongelli,
Gianfranco Favia,
Andrea Santarelli,
Roberto Cortelazzi and
Lorenzo Lo Muzio

Int. J. Environ. Res. Public Health2021, 18(15), 7831;https://doi.org/10.3390/ijerph18157831

23 July 2021

The prolonged use of intranasal cocaine can destroy the nasal architecture with the erosion of the palate, turbinates, and ethmoid sinuses causing cocaine-induced midline lesions (CIMDL). The CIMDL display a clinical pattern mimicking variable diseas...

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Article

5 Citations

6,411 Views

10 Pages

Gene Expression Analysis in Patients with Cocaine-Induced Midline Destructive Lesions

Matteo Trimarchi,
Giacomo Bertazzoni,
Alessandro Vinciguerra,
Celia Pardini,
Fabio Simeoni,
Davide Cittaro,
Mario Bussi and
Dejan Lazarevic

Medicina2021, 57(9), 861;https://doi.org/10.3390/medicina57090861

24 August 2021

Background and Objectives: Cocaine users may present with positive antineutrophil cytoplasmic antibodies (ANCA) and severe midline destructive lesions (CIMDL) which are histologically characterized by massive apoptosis. However, histopathological and...

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Case Report

19 Citations

13,460 Views

10 Pages

Cocaine-Induced Midline Destructive Lesions: A Real Challenge in Oral Rehabilitation

Andrea Rampi,
Alessandro Vinciguerra,
Stefano Bondi,
Nicoletta Stella Policaro and
Giorgio Gastaldi

Int. J. Environ. Res. Public Health2021, 18(6), 3219;https://doi.org/10.3390/ijerph18063219

20 March 2021

Cocaine abuse is associated with severe local effects on mucosal and osteocartilaginous structures, with a centrifugal spreading pattern from the nose, a condition known as cocaine-induced midline destructive lesions (CIMDL). When the soft or hard pa...

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Review

12 Citations

22,437 Views

19 Pages

Cocaine- and Levamisole-Induced Vasculitis: Defining the Spectrum of Autoimmune Manifestations

Luca Iorio,
Federica Davanzo,
Diego Cazzador,
Marta Codirenzi,
Eleonora Fiorin,
Elisabetta Zanatta,
Piero Nicolai,
Andrea Doria and
Roberto Padoan

J. Clin. Med.2024, 13(17), 5116;https://doi.org/10.3390/jcm13175116

28 August 2024

Drug-induced or associated vasculitis is a prevalent form of vasculitis that resembles primary idiopathic antineutrophil cytoplasmic autoantibody (ANCA) vasculitis (AAV). Cocaine is a diffuse psychostimulant drug and levamisole is a synthetic compoun...

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Article

4,988 Views

19 Pages

Comprehensive Management of Cocaine-Induced Midline Destructive Lesions: A Young-IfOS Consensus

Alberto Maria Saibene,
Letizia Nitro,
Florent Carsuzaa,
Mihaela Alexandru,
Vincent Bedarida,
Matteo Di Bari,
Léa Fath,
Ainhoa Garcia-Lliberos,
Margaux Legré and
Maxime Fieux
+ 8 authors

J. Pers. Med.2025, 15(6), 231;https://doi.org/10.3390/jpm15060231

3 June 2025

Background: Recreational nasal cocaine use (RNCU) presents a significant challenge for rhinologists due to cocaine-induced midline destructive lesions (CIMDLs). This clinical consensus statement (CCS) offers guidelines for diagnosing, assessing, and...

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Communication

4 Citations

2,116 Views

13 Pages

Surgical Management of Oro-Nasal Communication in Cocaine-Induced Lesions: Temporalis Muscle Flap with Le Fort I Osteotomy

Ettore Lupi,
Alessandra Ciccozzi,
Roberto Becelli,
Mario Mannino,
Sara Bernardi and
Filippo Giovannetti

J. Clin. Med.2025, 14(6), 2033;https://doi.org/10.3390/jcm14062033

17 March 2025

Background: Cocaine is a recreational drug known for its negative impact on health and social and economic life. One of the complications for cocaine abusers is cocaine-induced midline destructive lesion (CIMDL) syndrome, which includes the extensive...

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