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3 Results Found

  • Review
  • Open Access
12 Citations
7,341 Views
33 Pages

The Many Facets of Metzincins and Their Endogenous Inhibitors: Perspectives on Ovarian Cancer Progression

  • Ruth M. Escalona,
  • Emily Chan,
  • George Kannourakis,
  • Jock K. Findlay and
  • Nuzhat Ahmed

Approximately sixty per cent of ovarian cancer patients die within the first five years of diagnosis due to recurrence associated with chemoresistance. The metzincin family of metalloproteinases is enzymes involved in matrix remodeling in response to...

(This article belongs to the Special Issue Tumor Microenvironment)
  • Article
  • Open Access
6 Citations
2,665 Views
11 Pages

Weill–Marchesani syndrome (WMS) is a rare genetic inherited disorder with autosomal recessive and dominant modes of inheritance. WMS is characterized by the association of short stature, brachydactyly, joint stiffness, eye anomalies, including...

(This article belongs to the Special Issue Molecular Research in Heart Disease)
  • Review
  • Open Access
7 Citations
4,243 Views
31 Pages

Prostate cancer remains a leading cause of cancer-related morbidity in men. Potentially important regulators of prostate cancer progression are members of the metzincin superfamily of proteases, principally through their regulation of the extracellul...

(This article belongs to the Special Issue Proteolysis of Extracellular Matrix in Human Disease)