Next Article in Journal
Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus
Next Article in Special Issue
A ‘Furry-Tale’ of Zika Virus Infection: What Have We Learned from Animal Models?
Previous Article in Journal
Engineering RNA Virus Interference via the CRISPR/Cas13 Machinery in Arabidopsis
Previous Article in Special Issue
RVFV Infection in Goats by Different Routes of Inoculation
Article

Different Outcomes of Experimental Hepatitis E Virus Infection in Diverse Mouse Strains, Wistar Rats, and Rabbits

1
Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany
2
Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Südufer 10, 17493 Greifswald-Insel Riems, Germany
3
PathoGuard Consult, 64342 Seeheim-Jugenheim, Germany
4
German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel, 17493 GreifswaldInsel Riems, Germany
*
Author to whom correspondence should be addressed.
Present address: Institute for Immunology, Centre for Infection Medicine, Freie Universität Berlin, 14163 Berlin, Germany.
Present address: Medical laboratory, Labor Doz. Dr. Stefan Mustafa, 1030 Wien, Austria.
§
Present address: Specialist department for veterinary and food control, District Ludwigslust-Parchim, 19288 Ludwigslust, Germany.
Viruses 2019, 11(1), 1; https://doi.org/10.3390/v11010001
Received: 30 October 2018 / Revised: 11 December 2018 / Accepted: 19 December 2018 / Published: 20 December 2018
(This article belongs to the Special Issue Animal Models for Viral Diseases)
Hepatitis E virus (HEV) is the causative agent of acute hepatitis E in humans in developing countries, but autochthonous cases of zoonotic genotype 3 (HEV-3) infection also occur in industrialized countries. In contrast to swine, rats, and rabbits, natural HEV infections in mice have not yet been demonstrated. The pig represents a well-established large animal model for HEV-3 infection, but a suitable small animal model mimicking natural HEV-3 infection is currently missing. Therefore, we experimentally inoculated C57BL/6 mice (wild-type, IFNAR−/−, CD4−/−, CD8−/−) and BALB/c nude (nu/nu) mice, Wistar rats, and European rabbits with a wild boar-derived HEV-3 strain and monitored virus replication and shedding, as well as humoral immune responses. HEV RNA and anti-HEV antibodies were detected in one and two out of eight of the rats and all rabbits inoculated, respectively, but not in any of the mouse strains tested. Remarkably, immunosuppressive dexamethasone treatment of rats did not enhance their susceptibility to HEV infection. In rabbits, immunization with recombinant HEV-3 and ratHEV capsid proteins induced protection against HEV-3 challenge. In conclusion, the rabbit model for HEV-3 infection may serve as a suitable alternative to the non-human primate and swine models, and as an appropriate basis for vaccine evaluation studies. View Full-Text
Keywords: Hepatitis E virus; genotype 3; wild boar; mouse; rat; rabbit; knockout mouse; BALB/c; C57BL/6; animal model Hepatitis E virus; genotype 3; wild boar; mouse; rat; rabbit; knockout mouse; BALB/c; C57BL/6; animal model
Show Figures

Figure 1

MDPI and ACS Style

Schlosser, J.; Dähnert, L.; Dremsek, P.; Tauscher, K.; Fast, C.; Ziegler, U.; Gröner, A.; Ulrich, R.G.; Groschup, M.H.; Eiden, M. Different Outcomes of Experimental Hepatitis E Virus Infection in Diverse Mouse Strains, Wistar Rats, and Rabbits. Viruses 2019, 11, 1. https://doi.org/10.3390/v11010001

AMA Style

Schlosser J, Dähnert L, Dremsek P, Tauscher K, Fast C, Ziegler U, Gröner A, Ulrich RG, Groschup MH, Eiden M. Different Outcomes of Experimental Hepatitis E Virus Infection in Diverse Mouse Strains, Wistar Rats, and Rabbits. Viruses. 2019; 11(1):1. https://doi.org/10.3390/v11010001

Chicago/Turabian Style

Schlosser, Josephine; Dähnert, Lisa; Dremsek, Paul; Tauscher, Kerstin; Fast, Christine; Ziegler, Ute; Gröner, Albrecht; Ulrich, Rainer G.; Groschup, Martin H.; Eiden, Martin. 2019. "Different Outcomes of Experimental Hepatitis E Virus Infection in Diverse Mouse Strains, Wistar Rats, and Rabbits" Viruses 11, no. 1: 1. https://doi.org/10.3390/v11010001

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop