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Open AccessReview

Non-Human Primate Models of Enteric Viral Infections

by Karol Sestak 1,2
1
Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA
2
PreCliniTria, LLC, Mandeville, LA 70471, USA
Viruses 2018, 10(10), 544; https://doi.org/10.3390/v10100544
Received: 24 August 2018 / Revised: 20 September 2018 / Accepted: 3 October 2018 / Published: 5 October 2018
(This article belongs to the Special Issue Animal Models for Viral Diseases)
There is an important role non-human primates (NHP) play in biomedical research. Phylogenetic proximity of any of the NHP species to Homo sapiens assures that much better translatability of research outcomes from model studies involving human diseases can be achieved than from those generated with other pre-clinical systems. Our group and others used during past two decades NHPs in research directed towards viral and autoimmune disorders of the gastrointestinal tract. This review summarizes progress made in the area of enteric viral infections including its applicability to human disease. View Full-Text
Keywords: enteric virus; non-human primate; virome; macaque; dysbiosis; enteritis; diarrhea; animal model; rotavirus; calicivirus; gut microbiome enteric virus; non-human primate; virome; macaque; dysbiosis; enteritis; diarrhea; animal model; rotavirus; calicivirus; gut microbiome
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Sestak, K. Non-Human Primate Models of Enteric Viral Infections. Viruses 2018, 10, 544.

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