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Open AccessReview

Small Animal Models of Respiratory Viral Infection Related to Asthma

1
Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI 48109, USA
2
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Viruses 2018, 10(12), 682; https://doi.org/10.3390/v10120682
Received: 31 October 2018 / Revised: 21 November 2018 / Accepted: 29 November 2018 / Published: 1 December 2018
(This article belongs to the Special Issue Animal Models for Viral Diseases)
Respiratory viral infections are strongly associated with asthma exacerbations. Rhinovirus is most frequently-detected pathogen; followed by respiratory syncytial virus; metapneumovirus; parainfluenza virus; enterovirus and coronavirus. In addition; viral infection; in combination with genetics; allergen exposure; microbiome and other pathogens; may play a role in asthma development. In particular; asthma development has been linked to wheezing-associated respiratory viral infections in early life. To understand underlying mechanisms of viral-induced airways disease; investigators have studied respiratory viral infections in small animals. This report reviews animal models of human respiratory viral infection employing mice; rats; guinea pigs; hamsters and ferrets. Investigators have modeled asthma exacerbations by infecting mice with allergic airways disease. Asthma development has been modeled by administration of virus to immature animals. Small animal models of respiratory viral infection will identify cell and molecular targets for the treatment of asthma. View Full-Text
Keywords: animal model; asthma; respiratory disease; rhinovirus; viral infection animal model; asthma; respiratory disease; rhinovirus; viral infection
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MDPI and ACS Style

Han, M.; Rajput, C.; Ishikawa, T.; Jarman, C.R.; Lee, J.; Hershenson, M.B. Small Animal Models of Respiratory Viral Infection Related to Asthma. Viruses 2018, 10, 682.

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