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Vaccines
Special Issues
Vaccines and Animal Health: 2nd Edition
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Vaccines and Animal Health: 2nd Edition

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 934

Special Issue Editors

Dr. Matteo Legnardi

E-Mail Website
Guest Editor
Department of Animal Medicine, Production and Health (MAPS), University of Padua, Viale dell’Università, 16, 35020 Legnaro, Italy
Interests: molecular epidemiology; viral diseases; infectious bronchitis virus; infectious bursal disease virus
Special Issues, Collections and Topics in MDPI journals
Dr. Claudia Maria Tucciarone

E-Mail Website
Guest Editor
Department of Animal Medicine, Production and Health, University of Padova, 35020 Legnaro, Italy
Interests: infectious diseases; epidemiology; vaccine kinetics; viruses of companion animals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There is no doubt that vaccines represent a crucial resource for veterinary medicine, allowing for effectively preventing burdensome infectious and parasitic diseases of both producing and companion animals, and aiding in the pursuit of the One Health vision. Nonetheless, research on animal vaccines is progressing continuously to cope with the emergence of novel epidemiological threats, changes in animal production, a stronger link among owners and pets within the domestic environment, and technological advancements.

This Special Issue is aimed at collecting original research articles and reviews on the applications of vaccines in all fields of animal health, further advancing the knowledge of already available preparations or proposing novel solutions and applications.

Dr. Matteo Legnardi
Dr. Claudia Maria Tucciarone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • veterinary vaccines
  • parasitic diseases
  • vaccinology
  • infectious diseases
  • livestock
  • poultry
  • companion animals

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Related Special Issue

Published Papers (1 paper)

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Research

10 pages, 1271 KB  
Article
A Recombinant Subunit Vaccine Against Chicken Infectious Anemia Virus Elicits Protective Immunity via VP2-Assisted VP1 Refolding
by Shihao Li, Mingxue Hu, Yanping Zhang, Yulu Duan, Ru Guo, Huijing Sun, Wenzhuo Ma, Xiaole Qi, Hongyu Cui, Suyan Wang, Yuntong Chen, Yongzhen Liu and Yulong Gao
Vaccines 2026, 14(4), 292; https://doi.org/10.3390/vaccines14040292 - 25 Mar 2026
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Abstract
Background: Chicken infectious anemia virus (CIAV) is a globally significant immunosuppressive pathogen that causes substantial economic losses to the poultry industry, with particularly severe outbreaks in China in recent years. Given the limitations of existing vaccines, especially the residual virulence associated with live [...] Read more.
Background: Chicken infectious anemia virus (CIAV) is a globally significant immunosuppressive pathogen that causes substantial economic losses to the poultry industry, with particularly severe outbreaks in China in recent years. Given the limitations of existing vaccines, especially the residual virulence associated with live attenuated vaccines, there is an urgent need to develop novel, safer, and more effective vaccine strategies. Methods: In this study, the VP1 and VP2 genes of CIAV were cloned and expressed in Escherichia coli to develop a cost-effective subunit vaccine. Since VP1 primarily formed inclusion bodies, a “VP2-assisted co-refolding” strategy was employed. This involved denaturing VP1 and refolding it via gradient dialysis in the presence of soluble VP2, thereby leveraging VP2’s natural chaperone-like function to restore conformational epitopes. The refolded VP1/VP2 protein complexes, emulsified at different ratios, were used to immunize 3-day-old specific pathogen-free (SPF) chickens, followed by challenge with a virulent CIAV strain. Results: The vaccine formulation with a VP1:VP2 ratio of 1:1 provided the best protection, achieving 71.4% (5/7) protective efficacy, as evidenced by significantly reduced thymic atrophy and a higher thymus index. Conclusions: These findings validate the feasibility of using an economical prokaryotic expression system combined with a rational protein refolding strategy to produce a protective subunit vaccine candidate against CIAV, offering a promising alternative for disease control. Full article
(This article belongs to the Special Issue Vaccines and Animal Health: 2nd Edition)
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