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TropicalMed
Special Issues
Plasmodium falciparum Treatment: Resistance, Drug Development, Implementation and Access
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Plasmodium falciparum Treatment: Resistance, Drug Development, Implementation and Access

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Infectious Diseases".

Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 2234

Special Issue Editor

Prof. Dr. Ghyslain Mombo-Ngoma

E-Mail Website
Guest Editor
1. Bernhard Nocht Institute for Tropical Medicine (BNITM) and University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany
2. Centre de Recherches Médicales de Lambaréné (CERMEL), 242 Lambaréné, Gabon
Interests: malaria; implementation research; clinical trials; maternal and child health

Special Issue Information

Dear Colleagues,

Today’s greatest challenge in the control and management of malaria is the emergence and spread of artemisinin resistance, manifesting in delayed parasite clearance after therapy, as observed in the Greater Mekong sub-region in South-East Asia, and more recently in Rwanda and Uganda. This is the major reason behind the urgent need to achieve the development of new combinations of antimalarial drugs with new mechanisms of action.

This Special Issue aims to establish the state of the art in malaria drug resistance and the current portfolios of antimalarial drug research and development and access.

Prof. Dr. Ghyslain Mombo-Ngoma
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Tropical Medicine and Infectious Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • malaria drug resistance
  • plasmodium falciparum
  • drug development
  • implementation research
  • access to drugs

Published Papers (1 paper)

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Research

15 pages, 964 KiB  
Article
Drug Resistance Molecular Markers of Plasmodium falciparum and Severity of Malaria in Febrile Children in the Sentinel Site for Malaria Surveillance of Melen in Gabon: Additional Data from the Plasmodium Diversity Network African Network
by Jacques Mari Ndong Ngomo, Denise Patricia Mawili-Mboumba, Noé Patrick M’Bondoukwé, Bridy Moutombi Ditombi, Jeanne Vanessa Koumba Lengongo, Fanny Bertrande Batchy Ognagosso and Marielle Karine Bouyou-Akotet
Trop. Med. Infect. Dis. 2023, 8(4), 184; https://doi.org/10.3390/tropicalmed8040184 - 23 Mar 2023
Viewed by 1614
Abstract
The objective of this study was to analyze the relationship between the frequency of artemisinin-based combination (ACT) drug resistance molecular markers and clinical forms of P. falciparum malaria and parasitemia. A cross-sectional study was carried out between January and April 2014 at the [...] Read more.
The objective of this study was to analyze the relationship between the frequency of artemisinin-based combination (ACT) drug resistance molecular markers and clinical forms of P. falciparum malaria and parasitemia. A cross-sectional study was carried out between January and April 2014 at the Operational Clinical Research Unit of Melen in febrile children aged 12 to 240 months with a Plasmodium sp. infection. A total of 3 mL of peripheral blood collected from an EDTA tube was used for leukocyte depletion. DNA mutation detection was performed by next generation sequencing (NGS). A total of 1075 patients were screened for malaria. Among them, 384 had a Plasmodium infection. P. falciparum mono-infection was found in 98.9% of the patients. Pfcrt-326T mutation was found in all isolates, while 37.9% had Pfmdr2-484I mutant allele. The highest median parasite densities were found in patients infected by parasites carrying the CVIET haplotype of the Pfcrt gene. The different genetic profiles found here, and their variations according to clinical and biological signs of severe malaria, are additional arguments for the surveillance of P. falciparum strains. Full article
(This article belongs to the Special Issue Plasmodium falciparum Treatment: Resistance, Drug Development, Implementation and Access)
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