Infectious Disease Prevention and Control: A One Health Approach

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Infectious Diseases".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 1025

Special Issue Editor


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Guest Editor
Infectious Diseases Unit, Hippokration Hospital, Konstantinoupoleos 49, 54642 Thessaloniki, Greece
Interests: infection prevention; infection control; emerging infectious diseases; MDR pathogens

Special Issue Information

Dear Colleagues,

One Health is a unified approach whose aim is to sustainably balance and optimise the health of people, animals, and ecosystems. The health of humans, domestic and wild animals, plants, and the wider environment (including ecosystems) are interrelated and reciprocally affect each other. Population growth and expansion into natural environmental habitats inevitably lead to closer human interactions, as well as those of humans with wild animals and domestic animals and wildlife.

Climate change, deforestation, and intensive farming, which aggravate the destruction of wild animals’ habitats and increase the movement of people, animals, and their products, are dictated by globalisation and contribute to the start and spread of zoonoses. More than 60% of the new and emerging infectious diseases that threaten human health originate in animal populations and can be further transmitted, either by direct contact or through vectors, to humans, potentially leading to epidemics or pandemic outbreaks. These threats are significantly increasing in frequency and severity over time, with tremendous long-term impacts. The recent COVID-19 pandemic, which led to millions of deaths globally, presents one of the strongest negative examples.

By linking humans, animals, and the environment, One Health can help us to address the full spectrum of disease control—from prevention to detection, preparedness, response, and management—and can contribute to global health security. This Special Issue, Surveillance techniques and field research are invited to provide insight into the early detection of environmental and vector/intermediate host-related factors facilitating the development of emerging infectious disease outbreaks. On the other hand, the development of sensitive and accurate diagnostic tests is encouraged to promptly recognise manifestations of zoonoses that may pose a significant threat to public health. The spectrum of diseases to be covered ranges from epidemics of air-borne and/or food-borne diseases to emerging vector-borne infectious diseases and the spread of environmentally favoured fungi.

Dr. Athina Pyrpasopoulou
Guest Editor

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Keywords

  • one health
  • emerging infectious diseases
  • disease outbreaks
  • zoonoses
  • climate change

Published Papers (1 paper)

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Research

19 pages, 2697 KiB  
Article
Characterization of Antibiotic Resistance in Select Tertiary Hospitals in Uganda: An Evaluation of 2020 to 2023 Routine Surveillance Data
by Jonathan Mayito, Daniel Kibombo, Charles Olaro, Susan Nabadda, Consolata Guma, Immaculate Nabukenya, Andrew Busuge, Flavia Dhikusooka, Alex Andema, Peter Mukobi, Nathan Onyachi, Ben Watmon, Stephen Obbo, Alfred Yayi, James Elima, Celestine Barigye, Filbert J. Nyeko, Ibrahim Mugerwa, Musa Sekamatte, Joel Bazira, Richard Walwema, Mohammed Lamorde, Francis Kakooza and Henry Kajumbulaadd Show full author list remove Hide full author list
Trop. Med. Infect. Dis. 2024, 9(4), 77; https://doi.org/10.3390/tropicalmed9040077 - 05 Apr 2024
Viewed by 853
Abstract
Antimicrobial resistance (AMR) is a public health concern in Uganda. We sought to conduct an extended profiling of AMR burden at selected Ugandan tertiary hospitals. We analyzed routine surveillance data collected between October 2020 and March 2023 from 10 tertiary hospitals. The analysis [...] Read more.
Antimicrobial resistance (AMR) is a public health concern in Uganda. We sought to conduct an extended profiling of AMR burden at selected Ugandan tertiary hospitals. We analyzed routine surveillance data collected between October 2020 and March 2023 from 10 tertiary hospitals. The analysis was stratified according to the hospital unit, age, gender, specimen type, and time. Up to 2754 isolates were recovered, primarily from pus: 1443 (52.4%); urine: 1035 (37.6%); and blood: 245 (8.9%). Most pathogens were Staphylococcus aureus, 1020 (37%), Escherichia coli, 808 (29.3%), and Klebsiella spp., 200 (7.3%). Only 28% of Escherichia coli and 42% of the other Enterobacterales were susceptible to ceftriaxone, while only 44% of Staphylococcus aureus were susceptible to methicillin (56% were MRSA). Enterococcus spp. susceptibility to vancomycin was 72%. The 5–24-year-old had 8% lower ampicillin susceptibility than the >65-year-old, while the 25–44-year-old had 8% lower ciprofloxacin susceptibility than the >65-year-old. The 0–4-year-old had 8% higher ciprofloxacin susceptibility. Only erythromycin susceptibility varied by sex, being higher in males. Escherichia coli ciprofloxacin susceptibility in blood (57%) was higher than in urine (39%) or pus (28%), as was ceftriaxone susceptibility in blood (44%) versus urine (34%) or pus (14%). Klebsiella spp. susceptibility to ciprofloxacin and meropenem decreased by 55% and 47%, respectively, during the evaluation period. During the same period, Escherichia coli ciprofloxacin susceptibility decreased by 40%, while Staphylococcus aureus gentamicin susceptibility decreased by 37%. Resistance was high across the Access and Watch antibiotic categories, varying with time, age, sex, specimen type, and hospital unit. Effective antimicrobial stewardship targeted at the critical AMR drivers is urgently needed. Full article
(This article belongs to the Special Issue Infectious Disease Prevention and Control: A One Health Approach)
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