Pathogenesis of Plasmodium falciparum Malaria
A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Vector-Borne Diseases".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 3455
Special Issue Editor
Special Issue Information
Dear Colleagues,
Malaria is one of the most important vector-borne diseases, causing over 200 million infections with estimated deaths of more than 600,000 yearly worldwide. Out of the various species causing malaria infection, Plasmodium falciparum is the most prevalent and causes severe infections. Resistance to antimalarial drugs, lack of a potent antimalarial vaccine, and genetic diversity among the circulating P. falciparum species pose challenges in the eradication of malaria from endemic areas. The clinical outcome of malaria is thought to be mainly contributed by the host, parasite, and environmental factors. In P. falciparum, an indirect correlation of the clinical manifestation has been reported with the biological characteristic of the parasites which determines the virulence to some extent. Studying genetic diversity enables the prediction of patterns of emergence and spread of phenotype of the novel antigenic variants leading to diverse clinical complication, drug resistance, or escape of vaccine-induced immunity.
In this Special Issue, we invite authors to share their latest research on P. falciparum genetic diversity and drug resistance. This issue also welcomes authors to publish their studies establishing a relationship between genetic diversity and clinical manifestations and ultimately pathogenesis of the disease.
Dr. Hargobinder Kaur
Guest Editor
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Keywords
- Plasmodium falciparum
- genetic diversity
- drug resistance
- pathogenesis
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