The Functional Analysis of Uremic Toxins by Metabolomics

Dear Colleagues,

Metabolomic analysis is the comprehensive analysis of small molecules within the body. These small molecules are known as metabolites, and reflect the underlying biochemical activity and state of cells or tissues. Thus, metabolomic analysis using mass spectrometry is a powerful tool to capture disease-metabolic signatures, and widely used for biomarker discovery and understanding of pathogenesis.

Renal failure results in the accumulation of various uremic toxins, which are produced by biological synthetic pathway or microbiome in the circulation. Accumulated uremic toxins exert deleterious and cytotoxic effects on organs, and related to a variety of symptoms and organ-dysfunction in renal failure, such as renal damage, cardiovascular damage, mineral and bone disorder. Recently, it revealed that accumulated uremic toxins, indoxyl sulphate, p-cresyl sulphate and phenyl sulphate, in the circulation are imported into whole body organs in renal failure conditions.

The special issue entitled “The Functional Analysis of Uremic Toxins by Metabolomics ” focuses on understanding the roles of uremic toxins on organ-dysfunction in renal failure conditions. Especially, the studies that examined metabolic alterations by uremic toxins using cell lines, animal renal failure models,  and also clinical study assessed by mass spectrometry are welcome. In addition, the studies that visualized the metabolic alteration and accumulated uremic toxins in tissues using imaging mass spectrometry are also welcome.

Dr. Emiko Sato
Dr. Daisuke Saigusa
Guest Editors

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