Toxicity of Plant Natural Products and Their Applications

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Plant Toxins".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 950

Editors


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Guest Editor
1. Interdisciplinary Faculty of Toxicology, Texas A&M University, College Station, TX 77843, USA
2. Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA
Interests: oxidative stress; toxic mechanisms; phytochemistry; environmental chemistry; biochemistry; inflammation; endocrine disruption; emerging contaminants; remediation; mycotoxins; food safety

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Guest Editor
Department of Basic and Applied Sciences, University of Basilicata, 85100 Potenza, Italy
Interests: secondary plant metabolites; extraction and characterization of natural products; pharmaceutical and nutraceutical compounds; mass spectrometric analysis of bioactive compounds, toxins, and related metabolites; development and validation of analytical methods; environmental contaminants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plant-derived natural products have been established as a rich source of biaoctive compounds with various applications in environmental management, food preservation, human health and so on. Many of these phyto-products are essential for their functional and medicinal value; however, their potential toxic effect on animals, humans and ecosystems often limits the full exploration of their benefits. This collection, themed “Toxicity of Plant Natural Products and Their Applications” aims to provide a comprehensive assessment on both the benefial and toxic effects of plant-based natural products, highlighting the importance of toxicity evaluation in their development and applications. Contributions are expected to address acute and chronic toxicity, metabolism, bioaccumulation, dose–response relationships, and interactions with biological systems. Furthermore, studies involving modern toxicological approaches, omic technologies, in vitro and in vivo models in compuational toxicology, risk assessment frameworks that enhance understanding of efficacy and safety are welcomed. This collection seeks interdisciplinary contributions from environmental sciences, pharmacology, toxicology and chemistry.

Dr. Johnson O. Oladele
Dr. Filomena Lelario
Guest Editors

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Keywords

  • phytotoxicity
  • environmental toxicity
  • plant-derived compounds
  • mechanism of toxicity
  • natural products
  • human health
  • omics technologies

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Published Papers (1 paper)

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Research

36 pages, 3602 KB  
Article
A Comprehensive Chemical–Biological Investigation of the Moderately Toxic Plant Prospero autumnale: Insights into Its Bioactive Potential Using In Vitro and In Vivo Models
by Maroua Korichi, Ouanissa Smara, Lilya Harchaoui, Gilda D’Urso, Latifa Khattabi, Agostino Casapullo, Gianluigi Lauro, Maria Giovanna Chini, Giuseppe Bifulco, Alessio Cimmino, Hocine Dendougui, Wafa Zahnit, Marco Masi and Mahdi Belguidoum
Toxins 2026, 18(7), 285; https://doi.org/10.3390/toxins18070285 - 30 Jun 2026
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Abstract
Prospero autumnale L. is a Mediterranean medicinal plant traditionally employed for inflammatory and neurological disorders. Nonetheless, its safety profile, toxicity, and application for treating inflammation and pain are yet to be comprehensively established. This investigation aimed to assess the bioactivity and toxicity of [...] Read more.
Prospero autumnale L. is a Mediterranean medicinal plant traditionally employed for inflammatory and neurological disorders. Nonetheless, its safety profile, toxicity, and application for treating inflammation and pain are yet to be comprehensively established. This investigation aimed to assess the bioactivity and toxicity of extracts derived from its aerial (AgP) and underground (UgP) parts. The phytochemical constituents of various P. autumnale extracts were analyzed using LC-MS/MS, and their phenolic content was quantified. The biological activities were evaluated through in vitro assays—including antioxidant, anti-inflammatory, acetylcholinesterase-inhibitory, and photoprotection assessments—and in vivo experiments, including evaluations of acute oral toxicity, anti-inflammatory, and analgesic effects. UgP extracts demonstrated significant antioxidant activity, with the methanolic extract exhibiting the highest reducing and superoxide scavenging capacities. Dichloromethane and ethyl acetate extracts performed exceptionally well in ABTS and DPPH assays. The aqueous extract from AgP exhibited noteworthy anti-inflammatory and analgesic effects, surpassing diclofenac in vitro and demonstrating efficacy in vivo. It also showed considerable acetylcholinesterase inhibition, while the ethyl acetate extract displayed high photoprotective potential. The acute toxicity was moderate (LD50: 300–400 mg/kg), indicating dose-dependent risks. LC-MS/MS analysis revealed diverse phenolics potentially contributing to both therapeutic and adverse effects. This research enhances the medicinal prospects of P. autumnale, provides new perspectives on plant utilization, and suggests its potential as a natural anti-inflammatory agent. However, due to moderate toxicity and dose-dependent effects, cautious application is advised. These findings underscore the importance of toxicological evaluation alongside bioactivity screening in ethnopharmacology to ensure safety. Full article
(This article belongs to the Special Issue Toxicity of Plant Natural Products and Their Applications)
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