Special Issue "Risk Assessment of Mycotoxins in Feed and Food"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: 15 March 2022.

Special Issue Editor

Dr. HJ (Ine) Van der Fels-Klerx
E-Mail Website
Guest Editor
Wageningen Food Safety Research (WFSR), part of Wageningen University and Research Centre, NL-6700 AE Wageningen, The Netherlands
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Mycotoxins are a worldwide threat for animal and human health. Contamination of feed and food crops with mycotoxins results into contaminated feed and food products, which lead to animal and human health issues. Risk assessments are performed to determine the impact on animal and human health related to mycotoxin exposure. They form the basis for decision making on interventions to reduce risks. A risk assessments consists of the four related steps of: hazard identification; hazard characterization; exposure assessment and risk characterization. The risk assessment outcome includes a quantitative estimation of the adverse health effects that are likely to occur in a given population, with their probabilities. A full risk assessment needs a lot of data and resources to complete. As alternative methods, qualitative assessments and comparative approaches are being used, such as risk ratio and risk ranking methods. Modelling is a key component of all these approaches, in particular to include uncertainties and variability in the key input parameters.

This special issue of Toxins invites articles that address risk assessments of mycotoxins in feed and food, as well as steps thereof. The particular interest of this issue is with:

  • Exposure assessment, consisting of an estimation of the presence of mycotoxins in feed or food combined with an estimation of intake via feed or food;
  • Approaches to assess animal or human exposure to mycotoxins via intake, or to assess related health effects due to feed/food exposure of mycotoxins;
  • Modelling to estimate the presence of mycotoxins in feed or food crops, i.e. forecasting models for mycotoxins, and effects of agronomics and climate (change);
  • Estimation of the fate of mycotoxins in the feed or food supply chain and to estimate contamination in final products by experiments and/or modelling;
  • Estimation of the transfer of mycotoxins in animals to estimate mycotoxin presence in animal derived products, by experiments and/or modelling;
  • Risk ranking approaches to estimate and compare the (relative) risks of multiple mycotoxins to animal or human health.

For this special issue, there is no restriction to a particular mycotoxin. Experimental studies, such as in-vitro studies to investigate toxicological effects, chemical analytical studies and occurrence surveys are outside the scope of this special issue.

We look forward to reviewing original research or review articles, which will provide new insights into modelling approaches useful for risk assessment of mycotoxins.

Dr. HJ (Ine) Van der Fels-Klerx
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hazard characterization
  • exposure assessment
  • risk assessment
  • forecasting
  • modelling

Published Papers (1 paper)

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Research

Article
Physiological Effects of Deoxynivalenol from Naturally Contaminated Corn on Cerebral Tryptophan Metabolism, Behavioral Response, Gastrointestinal Immune Status and Health in Pigs Following a Pair-Feeding Model
Toxins 2021, 13(6), 393; https://doi.org/10.3390/toxins13060393 - 30 May 2021
Cited by 2 | Viewed by 1357
Abstract
This study investigated the impact of deoxynivalenol (DON) from naturally contaminated feed on pig growth, immune status, organ health, brain serotonin (5-Hydroxytryptamine, 5-HT) and behavior. Sixteen individually housed pigs (25.57 ± 0.98 kg, age 9 weeks) were randomly allotted to two dietary treatments: [...] Read more.
This study investigated the impact of deoxynivalenol (DON) from naturally contaminated feed on pig growth, immune status, organ health, brain serotonin (5-Hydroxytryptamine, 5-HT) and behavior. Sixteen individually housed pigs (25.57 ± 0.98 kg, age 9 weeks) were randomly allotted to two dietary treatments: without DON (CON) or with 3.8 mg/kg of DON (MT). Pigs were pair-fed to eliminate differences in feed intake (equal tryptophan (Trp) intake). Pigs fed CON received a daily ration based on the ad libitum feed consumption of their MT pair-mate. Performance was determined over 21 days and blood collected for immunological and oxidative stress parameters. Behavior was recorded for 12 h on days 0, 7, 14 and 21. After 21 days, pigs were euthanized to collect tissues for immune parameters, gut morphology and brain serotonin levels. Overall, pigs fed MT had greater weight gain compared with CON. Immunological and oxidative stress parameters were unaffected, but pigs fed MT had reduced villus height, crypt depth and villus-to-crypt ratio in the jejunum. Pigs consuming MT had reduced concentration of 5-HT and increased 5-HT turnover in the hypothalamus. Mycotoxin-fed pigs spent more time lying and sitting, and less time standing and drinking. In conclusion, consumption of DON impacted gastrointestinal tract structure, altered behavior and changed Trp metabolism through increasing 5-HT turnover in hypothalamus. Full article
(This article belongs to the Special Issue Risk Assessment of Mycotoxins in Feed and Food)
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