Special Issue "Application of Botulinum Neurotoxin in Lower Urinary Tract Dysfunctions: Where Are We Now? II"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 1109

Special Issue Editor

Special Issue Information

Dear Colleagues,

Following on from the first Special Issue on the topic, “Application of Botulinum Neurotoxin in Lower Urinary Tract Dysfunctions: Where Are We Now?”

In recent decades, botulinum toxin A has been widely used in the treatment of several lower urinary tract dysfunctions (LUTDs), such as overactive bladder syndrome (OAB), neurogenic detrusor overactivity (NDO), interstitial cystitis (IC), and voiding dysfunction. Although botulinum toxin A intravesical injection has been approved for OAB and NDO, the other application of this neurotoxin in LUTDs is yet to be approved. Because some clinical experiences of adverse events have limited its wide application, this treatment has gradually been considered as an unpopular procedure for LUTDs. However, evidence has shown that botulinum toxin A has advantages in LUTDs compared with oral pharmacological medications, especially in elderly OAB patients with cognitive dysfunction, patients with bladder neck dysfunction or dysfunctional voiding, idiopathic voiding dysfunction due to poor relaxation of the external sphincter, or intractable bladder pain syndrome due to IC or ketamine-induced cystitis, male patients with lower urinary tract symptoms and a small prostate, and pediatric patients with OAB or dysfunctional voiding. In addition, botulinum toxin A can also be carried across the urothelial barrier with the aid of bladder treatment such as liposomes or low-energy shock waves. There are several LUTDs other than OAB and NDO that can benefit from botulinum toxin A injection or intravesical instillation. This Special Issue welcomes original or review articles that fucus on the novel applications of botulinum toxin A in LUTDs, either in human or animal studies. The collection of this Special Issue of Toxins will provide updated knowledge and information on the current position of botulinum toxin A in functional urology and LUTDs.

Prof. Dr. Hann-Chorng Kuo
Guest Editor

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Keywords

  • overactive bladder
  • interstitial cystitis
  • neurogenic detrusor overactivity
  • voiding dysfunction
  • lower urinary tract symptoms

Published Papers (1 paper)

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Research

Article
Retrospective Observational Study of Treatment Patterns and Efficacy of onabotulinumtoxinA Therapy in Patients with Refractory Overactive Bladder in Clinical Practice
Toxins 2023, 15(5), 338; https://doi.org/10.3390/toxins15050338 - 15 May 2023
Viewed by 767
Abstract
This study aimed to evaluate the treatment patterns and long-term efficacy of onabotulinumtoxinA injections in a clinical setting. This single-center retrospective study was conducted on patients with refractory overactive bladder (OAB) aged 18 years or older who received onabotulinumtoxinA 100 IU administered between [...] Read more.
This study aimed to evaluate the treatment patterns and long-term efficacy of onabotulinumtoxinA injections in a clinical setting. This single-center retrospective study was conducted on patients with refractory overactive bladder (OAB) aged 18 years or older who received onabotulinumtoxinA 100 IU administered between April 2012 and May 2022. The primary endpoint was the treatment pattern, including the retreatment rate and OAB medication prescription pattern. The duration and effectiveness of onabotulinumtoxinA treatment were analyzed using the overactive bladder symptom score and voiding diaries. A total of 216 patients were enrolled in this study, and the overall patient satisfaction rate was 55.1%. After the first injection, 19.9% received a second treatment, and 6.1% received three or more injections. The median duration until the second injection was 10.7 months. Among the patients, 51.4% resumed OAB medications after 2.96 months. The presence of urodynamic detrusor overactivity was observed only in female patients (odds ratio, 23.65; 95% CI, 1.84 to 304.40), which was associated with a good response. In contrast to clinical trials, the degree of improvement and retreatment rate did not meet expectations. Our findings provide valuable insights into the effectiveness of onabotulinumtoxinA injections in patients with refractory OAB symptoms in real-world practice. Full article
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