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Article

Bisphenol A Coupled with a High-Fat Diet Promotes Hepatosteatosis through Reactive-Oxygen-Species-Induced CD36 Overexpression

by
Jyun-Lin Lee
1,
Yao-Chien Wang
2,
Yu-An Hsu
3,
Chih-Sheng Chen
4,5,6,
Rui-Cian Weng
7,8,
Yen-Pei Lu
8,
Chun-Yu Chuang
1,* and
Lei Wan
3,9,10,*
1
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300, Taiwan
2
Department of Emergency Medicine, Taichung Tzu Chi Hospital, Taichung 427, Taiwan
3
School of Chinese Medicine, China Medical University, Taichung 404, Taiwan
4
Division of Chinese Medicine, Asia University Hospital, Taichung 413, Taiwan
5
Department of Food Nutrition and Health Biotechnology, Asia University, Taichung 401, Taiwan
6
Department of Chinese Medicine, China Medicine University Hospital, Taichung 404, Taiwan
7
Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 106, Taiwan
8
National Applied Research Laboratories, Taiwan Instrument Research Institute (TIRI), Hsinchu 300, Taiwan
9
Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung 404, Taiwan
10
Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 413, Taiwan
*
Authors to whom correspondence should be addressed.
Toxics 2022, 10(5), 208; https://doi.org/10.3390/toxics10050208
Submission received: 8 March 2022 / Revised: 13 April 2022 / Accepted: 19 April 2022 / Published: 22 April 2022
(This article belongs to the Special Issue Plasticizer Exposure: Harmful Impact on Human Health)
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Abstract

Bisphenol A (BPA) is an endocrine-disrupting chemical that affects lipid metabolism and contributes to non-alcoholic fatty liver disease (NAFLD). The mechanism of BPA exposure in hepatic lipid accumulation and its potential effect on NAFLD remain unclear. This study investigated the effect of BPA-exposure-induced hepatic lipid deposition on the pathology of NAFLD and its underlying mechanism in vitro and in vivo. BPA increased intracellular reactive oxygen species (ROS) levels, and promoted fatty acid uptake through upregulation of a free fatty acid uptake transporter, cluster of differentiation 36 (CD36), in HUH-7 cells. Additionally, C57BL/6 mice administered a high-fat/high-cholesterol/high-cholic acid diet (HFCCD) and BPA (50 mg/kg body weight) for 8 weeks developed a steatohepatitis-like phenotype, characterized by alpha-smooth muscle actin (α-SMA, an indicator of hepatic fibrosis) and cleaved caspase 3 (an indicator of apoptosis) in hepatic tissue; moreover, they had a higher oxidative stress index of 8-hydroxydeoxyguanosine (8-OHdG) in liver tissue compared to the control group. Treatment with ROS scavenger n-acetylcysteine (NAC) ameliorated BPA-mediated HFCCD-induced lipid accumulation and steatohepatitis in the livers of treated mice. Our study indicates that BPA acts synergistically to increase hepatic lipid uptake and promote NAFLD development by stimulating ROS-induced CD36 overexpression.
Keywords: bisphenol A; reactive oxygen species; endocrine-disrupting chemical; CD36; non-alcoholic fatty liver disease; fatty acid uptake bisphenol A; reactive oxygen species; endocrine-disrupting chemical; CD36; non-alcoholic fatty liver disease; fatty acid uptake

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MDPI and ACS Style

Lee, J.-L.; Wang, Y.-C.; Hsu, Y.-A.; Chen, C.-S.; Weng, R.-C.; Lu, Y.-P.; Chuang, C.-Y.; Wan, L. Bisphenol A Coupled with a High-Fat Diet Promotes Hepatosteatosis through Reactive-Oxygen-Species-Induced CD36 Overexpression. Toxics 2022, 10, 208. https://doi.org/10.3390/toxics10050208

AMA Style

Lee J-L, Wang Y-C, Hsu Y-A, Chen C-S, Weng R-C, Lu Y-P, Chuang C-Y, Wan L. Bisphenol A Coupled with a High-Fat Diet Promotes Hepatosteatosis through Reactive-Oxygen-Species-Induced CD36 Overexpression. Toxics. 2022; 10(5):208. https://doi.org/10.3390/toxics10050208

Chicago/Turabian Style

Lee, Jyun-Lin, Yao-Chien Wang, Yu-An Hsu, Chih-Sheng Chen, Rui-Cian Weng, Yen-Pei Lu, Chun-Yu Chuang, and Lei Wan. 2022. "Bisphenol A Coupled with a High-Fat Diet Promotes Hepatosteatosis through Reactive-Oxygen-Species-Induced CD36 Overexpression" Toxics 10, no. 5: 208. https://doi.org/10.3390/toxics10050208

APA Style

Lee, J.-L., Wang, Y.-C., Hsu, Y.-A., Chen, C.-S., Weng, R.-C., Lu, Y.-P., Chuang, C.-Y., & Wan, L. (2022). Bisphenol A Coupled with a High-Fat Diet Promotes Hepatosteatosis through Reactive-Oxygen-Species-Induced CD36 Overexpression. Toxics, 10(5), 208. https://doi.org/10.3390/toxics10050208

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