Assessment of Novel Environmental Exposure on Humans

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Human Toxicology and Epidemiology".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1240

Special Issue Editors

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Guest Editor
1. National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli 350, Taiwan
2. Department of Safety, Health and Environmental Engineering, National United University, Miaoli, Taiwan
3. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
4. Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
5. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan
Interests: epidemiology; exposure science; biomonitoring; risk assessment; endocrine disruptors; biomarker
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Guest Editor
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung City 807, Taiwan
Interests: nanotechnology; sensors/biosensors; energy; environmental sciences; green chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Adverse health effects resulting from exposure to new emergency environmental factors in multiple media on human health have been of major concern worldwide. New threaten of physical, biological and chemical exposure from the indoor and outdoor environment would influence human health. For examples, persistent organic pollutants, endocrine disruptors, emerging environmental pollution, toxic metals, or drugs in different media are concerned determinants of environmental risk factors. Although the regulations of many legacy contaminants or drugs, like dioxins and DES, the accumulation in the human body would dramatically change; however, new substitutes of the above chemicals have been largely and widely applied in numerous products or re-shaped and distributed into the environment since the early 21 centuries. Meanwhile, factors change (like temperature, green land, radiation, fungi, etc.) by climate change would gradually affect our health. Increasing evidence revealed the impact of climate change occurred in the European, America, Asian and Africa, which raised the public concern about potential adverse health effects of individual or combined exposure to these new factors through multiple levels of exposure/media.

Low- and long-term exposure to the influences of above exposure factors triggers the disease progression in humans, including developmental, reproductive, endocrine hormone homeostasis, metabolic regulation, circulation, etc. Exploration of new biomarkers/ mediators for the above exposure plays a crucial role in disease prevention.  However, large unknown gaps on the exposure sources, biological effects, and risk assessment of concerned environmental pollutants on human’s health remain.

This Special Issue calls for submissions that focus on research investigating associations between new emergency environmental pollutants or important contaminants or drug exposures and human’s health, especially through epidemiological, biomonitoring, and novel approaches.

Dr. Po-Chin Huang
Dr. Vinoth Kumar Ponnusamy
Guest Editors

Manuscript Submission Information

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  • epidemiology
  • exposure assessment
  • risk assessment
  • human health
  • analytical method

Published Papers (1 paper)

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11 pages, 569 KiB  
The Association between 4-Tertiary-Octylphenol, Apoptotic Microparticles, and Carotid Intima-Media Thickness in a Young Taiwanese Population
by Chien-Yu Lin, Ching-Way Chen, Chikang Wang, Fung-Chang Sung and Ta-Chen Su
Toxics 2023, 11(9), 757; - 06 Sep 2023
Cited by 1 | Viewed by 939
As one of the most common alkylphenols, 4-tertiary-octylphenol (4-tOP) is commonly used in many consumer products. Our previous epidemiological study revealed a negative correlation between serum 4-tOP levels and carotid intima-media thickness (CIMT), which serves as a biomarker of arteriosclerosis. We aimed to [...] Read more.
As one of the most common alkylphenols, 4-tertiary-octylphenol (4-tOP) is commonly used in many consumer products. Our previous epidemiological study revealed a negative correlation between serum 4-tOP levels and carotid intima-media thickness (CIMT), which serves as a biomarker of arteriosclerosis. We aimed to explore the role of apoptotic microparticles, markers of vascular endothelial cell function, in the 4-tOP and CIMT connection. To investigate this, we enrolled 886 Taiwanese adolescents and young adults (aged 12–30 years) and examined the relationships among serum 4-tOP levels, apoptotic microparticles (CD31+/CD42a−, CD31+/CD42a+), and CIMT. Our results showed negative associations among serum 4-tOP levels, both apoptotic microparticles, and CIMT in multiple linear regression analysis. The odds ratios for CIMT (≥75th percentile) and the natural logarithm of 4-tOP were highest when both CD31+/CD42a− and CD31+/CD42a+ were greater than the 50th percentile. Conversely, the odds ratios were lowest when both CD31+/CD42a− and CD31+/CD42a+ were less than the 50th percentile. In the structural equation model, we demonstrated that serum 4-tOP levels were negatively correlated with CIMT and indirectly and negatively correlated with CIMT through both apoptotic microparticles. In conclusion, our study reported the inverse association between 4-tOP apoptotic microparticles and CIMT in a young Taiwanese population. Further experimental studies are needed to clarify these associations. Full article
(This article belongs to the Special Issue Assessment of Novel Environmental Exposure on Humans)
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