ROS and COVID
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (15 February 2021) | Viewed by 83360
Special Issue Editors
Interests: antioxidant activity; plant phenolics; exercise; functional foods; toxicology; redox nutrition; antioxidant administration
Special Issues, Collections and Topics in MDPI journals
Interests: immunology; structural biology; molecular biology; COVID-19; SARS-CoV-2 spike function; cholinergic pathway
Special Issues, Collections and Topics in MDPI journals
Interests: immunology; structural biology; molecular biology; COVID-19; SARS-CoV-2 spike function; cholinergic pathway
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2. While the disease is mild in many cases, severe COVID-19 involves a hyper-inflammatory response, commonly called a cytokine storm, characterized by the release of pro-inflammatory cytokines that can lead to acute respiratory distress syndrome and death. It is known that pulmonary immunity in elderly persons is compromised, with impaired innate and adaptive cellular immune responses and reduced function of the lung itself. While overall innate immune responses may decline with age, inflammatory cytokines such as IL-6 and TNF-a, and acute phase reactants such as C-reactive protein, are elevated in older adults, maintaining a low level of chronic inflammation associated with increased levels of oxidative stress which drive the sustained levels of inflammation. Risk factors for severe COVID-19 such as obesity and diabetes are also associated with oxidative stress. Viral entry into the cytoplasm of the lung host epithelial cells results in interactions that affect cell metabolism and induce oxidative stress responses. The resulting inflammation and oxidative stress may have a negative impact on the expression and function of pulmonary surfactant, further compromising gas exchange and surfactant-protein-mediated innate host defense. For this reason, the study of reactive oxidant species (ROS) of all facets (nutrition modalities, supplements administration, redox biomarker study, antioxidant involvement, drug–protein interaction, the genetics of lung innate immune molecules such as the surfactant proteins, and the physiology and/or biochemistry of ROS in COVID-19) is of particular interest and constitutes the scope of the present Special Issue.
Prof. Dr. Dimitrios Kouretas
Dr. Konstantinos Poulas
Dr. Konstantinos Farsalinos
Prof. Dr. Joanna Floros
Guest Editors
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