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Separations
Special Issues
Microfluidic Paper-Based Analytical Devices
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Microfluidic Paper-Based Analytical Devices

A special issue of Separations (ISSN 2297-8739).

Deadline for manuscript submissions: closed (30 April 2015) | Viewed by 9516

Special Issue Editors

Prof. Dr. Carlos D. Garcia

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Guest Editor
Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX, USA
Interests: design, operation and biological applications of microchips and capillary electrophoresis; design of biosensors
Prof. Dr. Wendell Coltro

E-Mail Website
Guest Editor
Institute of Chemistry, Federal University of Goias, Goiania, Brazil
Interests: Design and characterization of low-cost platforms for human health
Special Issues, Collections and Topics in MDPI journals
Dr. Lucas Blanes

E-Mail Website
Guest Editor
Centre for Forensic Science, University of Technology, Sydney, Australia
Interests: Development of portable microfluidic devices and analysis of forensic samples

Special Issue Information

Dear Colleagues,

In recent years, the paper substrate has appeared as a powerful platform for microfluidic applications. Since the pioneering work of the Whitesides’s group, the use of this substrate material has received growing attention. In this context, it is our pleasure to invite you to submit an article for a Special Issue dedicated to the subject of “microfluidic paper-based analytical devices (µPADs)” for which we serve as Guest Editors. This issue is focused on the dissemination of news on the latest advances, including applications, fabrication technologies, integration of analytical techniques or any similar innovative achievement. Reviews and mini-review articles are also welcome. We do hope that you accept this invitation and join in the continuing success of this area of expertise.

Prof. Dr. Carlos D. Garcia
Prof. Dr. Wendel Coltro
Dr. Lucas Blanes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • paper-based analytical devices
  • point-of-care diagnostics
  • µPADs
  • disposable microfluidic platforms
  • clinical assays

Published Papers (1 paper)

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Research

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Article
Poly(N-isopropylacrylamide) Hydrogels for Storage and Delivery of Reagents to Paper-Based Analytical Devices
by Haydn T. Mitchell, Spencer A. Schultz, Philip J. Costanzo and Andres W. Martinez
Chromatography 2015, 2(3), 436-451; https://doi.org/10.3390/chromatography2030436 - 17 Jul 2015
Cited by 12 | Viewed by 8880
Abstract
The thermally responsive hydrogel N,N'-methylenebisacrylamide-cross-linked poly(N-isopropylacrylamide) (PNIPAM) was developed and evaluated as a reagent storage and delivery system for microfluidic paper-based analytical devices (microPADs). PNIPAM was shown to successfully deliver multiple solutions to microPADs in specific sequences or simultaneously in [...] Read more.
The thermally responsive hydrogel N,N'-methylenebisacrylamide-cross-linked poly(N-isopropylacrylamide) (PNIPAM) was developed and evaluated as a reagent storage and delivery system for microfluidic paper-based analytical devices (microPADs). PNIPAM was shown to successfully deliver multiple solutions to microPADs in specific sequences or simultaneously in laminar-flow configuration and was found to be suitable for delivering four classes of reagents to the devices: Small molecules, enzymes, antibodies and DNA. PNIPAM was also able to successfully deliver a series of standard glucose solutions to microPADs equipped to perform a colorimetric glucose assay. The results of these tests were used to produce an external calibration curve, which in turn was used to determine the concentration of glucose in sample solutions. Finally, PNIPAM was used to store the enzyme horseradish peroxidase for 35 days under ambient conditions with no significant loss of activity. The combination of PNIPAM and microPADs may allow for more complex assays to be performed on paper-based devices, facilitate the preparation of external calibration curves in the field, and extend the shelf life of microPADs by stabilizing reagents in an easy-to-use format. Full article
(This article belongs to the Special Issue Microfluidic Paper-Based Analytical Devices)
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