Separation, Analysis and Biological Evaluation of Bioactive Compounds

Dear Colleagues,

The development of new procedures for the separation, extraction, characterization, and analysis of bioactive compounds, with either synthetic or natural origins, is of critical concern. For natural bioactive compounds, their general features, including structural diversity and complexity, and the existence of chiral centers and stereochemistry usually affect pharmacological actions, whereas synthetic chemicals represent the basis of pharmaceutical industrial production. Moreover, screening the biological activities of compounds by in vitro, in vivo, ex vivo, and in silico models introduces new opportunities for pharmaceutical and therapeutic applications. Additionally, many bioactive molecules can be reintroduced now, especially after revolutions in molecular biology, high-throughput screening, and in silico technologies. Several methods are engaged in the separation, extraction, identification, and analysis of bioactive compounds, including Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), UV-VIS spectrophotometry, hyphenated HPLC, GC analytical methods, etc. Thus, separation and structure identification are two stages in the drug discovery and development (DD and D) process.

Prof. Dr. Fatma M. Abdel Bar
Dr. Ahmed Awad Zaki
Dr. Ahmed Adel Ashour
Guest Editors

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