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Applications of Plasmonic Biosensing in Clinical Diagnosis

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Optical Sensors".

Deadline for manuscript submissions: closed (31 July 2020) | Viewed by 9122

Special Issue Editor


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Guest Editor
1. Department of Nursing and Physiotherapy, University of León, 24071 León, Spain
2. Institute of Food Science and Technology (ICTAL), La Serna 58, 24007 León, Spain
Interests: biosensors; plasmonic sensors; surface plasmon resonance; localized surface plasmon resonance; biofunctionalization strategies; biomedical applications; clinical diagnostics; point of care
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Special Issue Information

Dear Colleagues

Plasmonic biosensing provides label-free quantification of real-time biological interactions at the molecular level. The various applications of plasmonics have attracted considerable attention as medical diagnostic tools. Current efforts in developing nanotechnology-based approaches are being conducted to enhance the use of plasmonic biosensors as point of care devices. With the advance in the fabrication of nanopatterned surfaces and the functionalization of nanomaterials, the design of ultrasensitive plasmonic devices is one step closer to enabling their integration in medical settings. The most urgent and crucial stage involves the improvement of the bioactive sensing area in order to provide anti-fouling layers that succeed in clinical diagnosis when using complex and real matrices (for example, blood serum, saliva, and urine). Clinical applications of plasmonic biosensors cover a broad range of analytes from protein biomarkers to bacterial and virus pathogens and cancer diagnosis markers (for example, microRNA and living circulating tumor cells).

This Special Issue will compile innovative studies involving both novel transducer configurations and biofunctionalization strategies that open a route to plasmonic biosensors in clinical practice. Papers addressing the design of advanced developments based on miniaturization, multiplexing, and point of care testing are sought.

Dr. Elba Mauriz
Guest Editor

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Keywords

  • Plasmonic sensors
  • Biosensors
  • Biofunctionalization strategies
  • Nanopatterned surfaces
  • Nanoparticles
  • Point-of-care
  • Biomedical applications
  • Medical diagnostics
  • Miniaturization

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Published Papers (1 paper)

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Review

27 pages, 7946 KiB  
Review
Recent Progress in Plasmonic Biosensing Schemes for Virus Detection
by Elba Mauriz
Sensors 2020, 20(17), 4745; https://doi.org/10.3390/s20174745 - 22 Aug 2020
Cited by 74 | Viewed by 8279
Abstract
The global burden of coronavirus disease 2019 (COVID-19) to public health and global economy has stressed the need for rapid and simple diagnostic methods. From this perspective, plasmonic-based biosensing can manage the threat of infectious diseases by providing timely virus monitoring. In recent [...] Read more.
The global burden of coronavirus disease 2019 (COVID-19) to public health and global economy has stressed the need for rapid and simple diagnostic methods. From this perspective, plasmonic-based biosensing can manage the threat of infectious diseases by providing timely virus monitoring. In recent years, many plasmonics’ platforms have embraced the challenge of offering on-site strategies to complement traditional diagnostic methods relying on the polymerase chain reaction (PCR) and enzyme-linked immunosorbent assays (ELISA). This review compiled recent progress on the development of novel plasmonic sensing schemes for the effective control of virus-related diseases. A special focus was set on the utilization of plasmonic nanostructures in combination with other detection formats involving colorimetric, fluorescence, luminescence, or Raman scattering enhancement. The quantification of different viruses (e.g., hepatitis virus, influenza virus, norovirus, dengue virus, Ebola virus, Zika virus) with particular attention to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was reviewed from the perspective of the biomarker and the biological receptor immobilized on the sensor chip. Technological limitations including selectivity, stability, and monitoring in biological matrices were also reviewed for different plasmonic-sensing approaches. Full article
(This article belongs to the Special Issue Applications of Plasmonic Biosensing in Clinical Diagnosis)
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