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Micro/Nano-Devices for Biosensing: From Single Molecule Sensing to Device Applications—2nd Edition

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 1370

Special Issue Editor

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu 761-0395, Japan
Interests: single-molecule studies; genomic DNA; extracellular vesicles (EVs); micro/nanofluidics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, a biosensing technology based on the fusion of micro/nanodevices, including micro/nanofluidic chips, and biology has provided remarkable success, providing the development of novel concepts, tools and methods. In addition, the micro/nanostructure of these devices can provide about the same size and space as a single molecule or single cell, so they can be measured directly or from the surface of an organism or living body to them. These potentials hold considerable promise for applications in various fields such as basic biology, agriculture, environment, healthcare and medical science. This suggests that biosensing technology with micro/nanodevices has great potential to contribute more in those fields and to lead those biological fields to a new era.

We are pleased to invite you to contribute to this Special Issue entitled “Micro/Nano-Devices for Biosensing: From Single Molecule Sensing to Device Applications—2nd Edition”. This Special Issue covers a variety of biosensing devices from single molecules, extracellular vesicles (EVs)/liposomes, viruses, bacteria and cells, with applications in basic biology, agriculture, environment, healthcare and medical science, based on micro/nanodevices including micro/nanofluidic chips.

This issue seeks to showcase research papers, short communications, and review papers, including the most up-to-date results and information in the above research fields. Contributions to this Special Issue centered on detection, manipulation, imaging, characterization, monitoring, fabrication, instrumentation, methodologies and new concepts are welcome.

Dr. Ken Hirano
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • micro and nanodevice
  • lab on a chip
  • micro and nanofluidics
  • MEMS and NEMS
  • micro and nanofabrication
  • micro and nanostructures
  • virus
  • biopsy
  • immuno assay
  • bioanalysis
  • diagnostics
  • single molecule studies
  • single cell analysis
  • nanoparticles
  • biosensors in agriculture
  • biosensors in environment

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Published Papers (2 papers)

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Research

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12 pages, 5362 KB  
Article
Effect of Annealing Treatment on Sensing Response of Inorganic Film Taste Sensor to Sweet Substances
by Tomoki Shinta, Hidekazu Uchida and Yuki Hasegawa
Sensors 2025, 25(6), 1859; https://doi.org/10.3390/s25061859 - 17 Mar 2025
Viewed by 490
Abstract
The effect of annealing treatment on an inorganic film for taste sensors has not been fully elucidated. In this study, we developed an inorganic film taste sensor using SnO2 as a sensitive film and evaluated the effect of annealing treatment on its [...] Read more.
The effect of annealing treatment on an inorganic film for taste sensors has not been fully elucidated. In this study, we developed an inorganic film taste sensor using SnO2 as a sensitive film and evaluated the effect of annealing treatment on its sensing response to sweet substances. First, we confirmed from XRD patterns that annealing at 600 °C caused a change in crystal orientation. Next, the taste sensor response to acesulfame potassium solution, which is a high-intensity sweetener and an electrolyte, showed a negative response with high concentration dependence. On the other hand, the sensors exhibited a positive response to non-electrolytes such as aspartame and glucose, with the sensor annealed at 600 °C showing a larger response to non-electrolytes compared to the other sensors. In terms of concentration dependence, the response to aspartame was higher, whereas the response to glucose was lower. Also, a reduction in variability was observed after annealing treatment at 150 °C and 300 °C. This phenomenon was clarified by comprehensively investigating various properties. Full article
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Review

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20 pages, 2128 KB  
Review
A Review of Quartz Crystal Microbalance-Based Mercury Detection: Principles, Performance, and On-Site Applications
by Kazutoshi Noda, Kohji Marumoto and Hidenobu Aizawa
Sensors 2025, 25(16), 5118; https://doi.org/10.3390/s25165118 - 18 Aug 2025
Viewed by 527
Abstract
Mercury (Hg) is a globally recognized toxic element, and the Minamata Convention on Mercury entered into force in 2017 to address its associated risks. Under the United Nations Environment Programme, international efforts to reduce Hg emissions and monitor its environmental presence are ongoing. [...] Read more.
Mercury (Hg) is a globally recognized toxic element, and the Minamata Convention on Mercury entered into force in 2017 to address its associated risks. Under the United Nations Environment Programme, international efforts to reduce Hg emissions and monitor its environmental presence are ongoing. In support of these initiatives, we developed a simple and rapid mercury detection device based on a quartz crystal microbalance (QCM-Hg sensor), which utilizes the direct amalgamation reaction between Hg and a gold (Au) electrode. The experimental results demonstrated a proportional relationship between Hg concentration and the resulting oscillation frequency shift. Increased flow rates and prolonged measurement durations enhanced detection sensitivity. The system achieved a detection limit of approximately 1 µg/m3, comparable to that of commercially available analyzers. Furthermore, a measurement configuration integrating the reduction-vaporization method with the QCM-Hg sensor enabled the detection of mercury in aqueous samples. Based on the experimental results and the gas-phase detection sensitivity achieved to date, concentrations as low as approximately 0.05 µg/L appear to be detectable. These findings highlight the potential of the QCM-Hg system for on-site mercury monitoring. This review aims to provide a comprehensive yet concise overview of QCM-Hg sensor development and its potential as a next-generation tool for environmental and occupational mercury monitoring. Full article
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