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Recent Advances in Microfluidics-Integrated Optical Biosensors

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Optical Sensors".

Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 7115

Special Issue Editor


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Guest Editor
Institute of Biophysics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary
Interests: integrated optics; optical biosensors; microfluidics; microfabrication; label free detection; electrooptical sensors; dielectrophoresis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The emergence of integrated electronics marks the beginning of the integrated devices era. To successfully integrate them, parts should be smaller and smaller, which has led us to the microworld. The technology of creating microelectronics has brought the strong development of photolithography and photoresists. Some researchers have found that this know-how can be used for building integrated optical waveguides and molds for soft lithography to create microchannels as the building blocks of microfluidics. Later, it turned out that integrated optics and microfluidics can be combined. Recently, the interdisciplinary sciences are on the rise. One of them is Biophysics with its really booming field: biosensors. Here are just some examples of their superiority to the traditional techniques: label-free detection (less cost, shorter time, no or minimal demand on central laboratory services), and less sample volume is required.

We have this Special Issue for gathering the recent advances in the blooming field of integrated optical biosensors and their applications. Manuscripts are warmly welcome that report on the newest advances on topics, included but not limited to:

  • Label-free detection;
  • All optical biosensors;
  • Integrated optical sensory devices;
  • Evanescent field-based biosensors (ATR);
  • Surface plasmon resonance sensors;
  • Bragg Grating Fiber sensors (FBG);
  • Integrated optical microcavity sensors.

Dr. Sándor Valkai
Guest Editor

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Keywords

  • biosensors
  • label-free detection
  • evanescent wave sensor
  • integrated optical sensory devices
  • lab-on-a-chip devices
  • FBG (Bragg Grating Fiber)
  • surface plasmon resonance
  • ATR
  • leaky waveguide

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Published Papers (3 papers)

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Research

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13 pages, 1958 KiB  
Article
Label-Free Biosensor Based on Particle Plasmon Resonance Coupled with Diffraction Grating Waveguide
by Wei-Ting Hsu, Yu-Cheng Lin, Huang-Chin Yang, Devesh Barshilia, Po-Liang Chen, Fu-Chun Huang, Lai-Kwan Chau, Wen-Hsin Hsieh and Guo-En Chang
Sensors 2024, 24(17), 5536; https://doi.org/10.3390/s24175536 - 27 Aug 2024
Cited by 4 | Viewed by 1249
Abstract
Particle plasmon resonance (PPR), or localized surface plasmon resonance (LSPR), utilizes intrinsic resonance in metal nanoparticles for sensor fabrication. While diffraction grating waveguides monitor bioaffinity adsorption with out-of-plane illumination, integrating them with PPR for biomolecular detection schemes remains underexplored. This study introduces a [...] Read more.
Particle plasmon resonance (PPR), or localized surface plasmon resonance (LSPR), utilizes intrinsic resonance in metal nanoparticles for sensor fabrication. While diffraction grating waveguides monitor bioaffinity adsorption with out-of-plane illumination, integrating them with PPR for biomolecular detection schemes remains underexplored. This study introduces a label-free biosensing platform integrating PPR with a diffraction grating waveguide. Gold nanoparticles are immobilized on a glass slide in contact with a sample, while a UV-assisted embossed diffraction grating is positioned opposite. The setup utilizes diffraction in reflection to detect changes in the environment’s refractive index, indicating biomolecular binding at the gold nanoparticle surface. The positional shift of the diffracted beam, measured with varying refractive indices of sucrose solutions, shows a sensitivity of 0.97 mm/RIU at 8 cm from a position-sensitive detector, highlighting enhanced sensitivity due to PPR–diffraction coupling near the gold nanoparticle surface. Furthermore, the sensor achieved a resolution of 3.1 × 10−4 refractive index unit and a detection limit of 4.4 pM for detection of anti-DNP. The sensitivity of the diffracted spot was confirmed using finite element method (FEM) simulations in COMSOL Multiphysics. This study presents a significant advancement in biosensing technology, offering practical solutions for sensitive, rapid, and label-free biomolecule detection. Full article
(This article belongs to the Special Issue Recent Advances in Microfluidics-Integrated Optical Biosensors)
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14 pages, 5654 KiB  
Article
Paper-Based Microfluidic Analytical Device Patterned by Label Printer for Point-of-Care Blood Glucose and Hematocrit Detection Using 3D-Printed Smartphone Cassette
by Zong-Xiao Cai, Ming-Zhang Jiang, Ya-Ju Chuang and Ju-Nan Kuo
Sensors 2024, 24(15), 4792; https://doi.org/10.3390/s24154792 - 24 Jul 2024
Cited by 4 | Viewed by 1707
Abstract
This study presents a portable, low-cost, point-of-care (POC) system for the simultaneous detection of blood glucose and hematocrit. The system consists of a disposable origami microfluidic paper-based analytical device (μPAD) for plasma separation, filtration, and reaction functions and a 3D-printed cassette for hematocrit [...] Read more.
This study presents a portable, low-cost, point-of-care (POC) system for the simultaneous detection of blood glucose and hematocrit. The system consists of a disposable origami microfluidic paper-based analytical device (μPAD) for plasma separation, filtration, and reaction functions and a 3D-printed cassette for hematocrit and blood glucose detection using a smartphone. The origami μPAD is patterned using a cost-effective label printing technique instead of the conventional wax printing method. The 3D-printed cassette incorporates an array of LED lights, which mitigates the effects of intensity variations in the ambient light and hence improves the accuracy of the blood glucose and hematocrit concentration measurements. The hematocrit concentration is determined quantitatively by measuring the distance of plasma wicking along the upper layer of the origami μPAD, which is pretreated with sodium chloride and Tween 20 to induce dehydration and aggregation of the red blood cells. The filtered plasma also penetrates to the lower layer of the origami μPAD, where it reacts with embedded colorimetric assay reagents to produce a yellowish-brown complex. A color image of the reaction complex is captured using a smartphone inserted into the 3D-printed cassette. The image is analyzed using self-written RGB software to quantify the blood glucose concentration. The calibration results indicate that the proposed detection platform provides an accurate assessment of the blood glucose level over the range of 45–630 mg/dL (R2 = 0.9958). The practical feasibility of the proposed platform is demonstrated by measuring the blood glucose and hematocrit concentrations in 13 human whole blood samples. Taking the measurements obtained from commercial glucose and hematocrit meters as a benchmark, the proposed system has a differential of no more than 6.4% for blood glucose detection and 9.1% for hematocrit detection. Overall, the results confirm that the proposed μPAD is a promising solution for cost-effective and reliable POC health monitoring. Full article
(This article belongs to the Special Issue Recent Advances in Microfluidics-Integrated Optical Biosensors)
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Review

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21 pages, 5534 KiB  
Review
Recent Progress on Microfluidics Integrated with Fiber-Optic Sensors for On-Site Detection
by Weibin Wang, Ling Xia, Xiaohua Xiao and Gongke Li
Sensors 2024, 24(7), 2067; https://doi.org/10.3390/s24072067 - 24 Mar 2024
Cited by 9 | Viewed by 3187
Abstract
This review introduces a micro-integrated device of microfluidics and fiber-optic sensors for on-site detection, which can detect certain or several specific components or their amounts in different samples within a relatively short time. Fiber-optics with micron core diameters can be easily coated and [...] Read more.
This review introduces a micro-integrated device of microfluidics and fiber-optic sensors for on-site detection, which can detect certain or several specific components or their amounts in different samples within a relatively short time. Fiber-optics with micron core diameters can be easily coated and functionalized, thus allowing sensors to be integrated with microfluidics to separate, enrich, and measure samples in a micro-device. Compared to traditional laboratory equipment, this integrated device exhibits natural advantages in size, speed, cost, portability, and operability, making it more suitable for on-site detection. In this review, the various optical detection methods used in this integrated device are introduced, including Raman, ultraviolet–visible, fluorescence, and surface plasmon resonance detections. It also provides a detailed overview of the on-site detection applications of this integrated device for biological analysis, food safety, and environmental monitoring. Lastly, this review addresses the prospects for the future development of microfluidics integrated with fiber-optic sensors. Full article
(This article belongs to the Special Issue Recent Advances in Microfluidics-Integrated Optical Biosensors)
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