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Immunoassays and Biosensors
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Immunoassays and Biosensors

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Chemical Sensors".

Deadline for manuscript submissions: closed (25 June 2022) | Viewed by 13547

Special Issue Editor

Dr. Marina Cretich

E-Mail Website
Guest Editor
Istituto di Scienze e Tecnologie Chimiche “Giulio Natta” (SCITEC- CNR), Via Mario Bianco, 9, 20131 Milano, Italy
Interests: bioassay development; protein and peptide microarrays; extracellular vesicles characterization; infectious disease diagnostics; allergy profiling; biomarker discovery

Special Issue Information

Dear Colleagues,

Immunoassays are bioanalytical tools with a 60-year track record of successful applications in many fields spanning from clinical diagnostics to environmental monitoring. Yet, continuous innovations in assay design and detection principles coupled to new materials and protocols contribute to advance this technology towards optimal specificity and sensitivity, down to the single molecule detection. The happy marriage of immunoassays with biosensors has produced remarkable technologies applicable to medicine and life science research, including both point of care devices suitable for low-resource settings and sophisticated instrumentation for multiparameter and high-throughput analysis.

This Special Issue on “Immunoassay and Biosensors” aims to highlight recent methodological advances in the development of immune-based biosensing and their applications in life science. Topics include but are not limited to new materials and nanomaterials, novel biofunctionalization and bioconjugation methods, innovative detection principles (both label-based and label-free), assay design and strategies for enhanced sensitivity and specificity, microfluidics and systems integration, portable and wearable biosensors, and microarrays. Both original research papers and review articles describing the current state-of-the-art in immune-sensors are welcome.

Dr. Marina Cretich
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antibody
  • Biosensors
  • Immune biosensors
  • Diagnostics
  • Surface modification
  • Bioconjugation
  • Nanomaterials
  • Nanoparticles
  • Lab-on-chip
  • Point of care device
  • Biomarkers
  • Microarrays

Published Papers (2 papers)

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Research

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17 pages, 2025 KiB  
Article
Towards the Development of a 3-D Biochip for the Detection of Hepatitis C Virus
by Mariia Antipchik, Dmitry Polyakov, Ekaterina Sinitsyna, Apollinariia Dzhuzha, Mikhail Shavlovsky, Evgenia Korzhikova-Vlakh and Tatiana Tennikova
Sensors 2020, 20(9), 2719; https://doi.org/10.3390/s20092719 - 10 May 2020
Cited by 7 | Viewed by 3073
Abstract
The early diagnostics of hepatitis C virus (HCV) infections is currently one of the most highly demanded medical tasks. This study is devoted to the development of biochips (microarrays) that can be applied for the detection of HCV. The analytical platforms of suggested [...] Read more.
The early diagnostics of hepatitis C virus (HCV) infections is currently one of the most highly demanded medical tasks. This study is devoted to the development of biochips (microarrays) that can be applied for the detection of HCV. The analytical platforms of suggested devices were based on macroporous poly(glycidyl methacrylate-co-di(ethylene glycol) dimethacrylate) monolithic material. The biochips were obtained by the covalent immobilization of specific probes spotted onto the surface of macroporous monolithic platforms. Using the developed biochips, different variants of bioassay were investigated. This study was carried out using hepatitis C virus-mimetic particles (VMPs) representing polymer nanoparticles with a size close to HCV and bearing surface virus antigen (E2 protein). At the first step, the main parameters of bioassay were optimized. Additionally, the dissociation constants were calculated for the pairs “ligand–receptor” and “antigen–antibody” formed at the surface of biochips. As a result of this study, the analysis of VMPs in model buffer solution and human blood plasma was carried out in a format of direct and “sandwich” approaches. It was found that bioassay efficacy appeared to be similar for both the model medium and real biological fluid. Finally, limit of detection (LOD), limit of quantification (LOQ), spot-to-spot and biochip-to-biochip reproducibility for the developed systems were evaluated. Full article
(This article belongs to the Special Issue Immunoassays and Biosensors)
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Review

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57 pages, 6039 KiB  
Review
Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors
by Maria Kaloumenou, Evangelos Skotadis, Nefeli Lagopati, Efstathios Efstathopoulos and Dimitris Tsoukalas
Sensors 2022, 22(3), 1238; https://doi.org/10.3390/s22031238 - 06 Feb 2022
Cited by 40 | Viewed by 9676
Abstract
Early-stage disease diagnosis is of particular importance for effective patient identification as well as their treatment. Lack of patient compliance for the existing diagnostic methods, however, limits prompt diagnosis, rendering the development of non-invasive diagnostic tools mandatory. One of the most promising non-invasive [...] Read more.
Early-stage disease diagnosis is of particular importance for effective patient identification as well as their treatment. Lack of patient compliance for the existing diagnostic methods, however, limits prompt diagnosis, rendering the development of non-invasive diagnostic tools mandatory. One of the most promising non-invasive diagnostic methods that has also attracted great research interest during the last years is breath analysis; the method detects gas-analytes such as exhaled volatile organic compounds (VOCs) and inorganic gases that are considered to be important biomarkers for various disease-types. The diagnostic ability of gas-pattern detection using analytical techniques and especially sensors has been widely discussed in the literature; however, the incorporation of novel nanomaterials in sensor-development has also proved to enhance sensor performance, for both selective and cross-reactive applications. The aim of the first part of this review is to provide an up-to-date overview of the main categories of sensors studied for disease diagnosis applications via the detection of exhaled gas-analytes and to highlight the role of nanomaterials. The second and most novel part of this review concentrates on the remarkable applicability of breath analysis in differential diagnosis, phenotyping, and the staging of several disease-types, which are currently amongst the most pressing challenges in the field. Full article
(This article belongs to the Special Issue Immunoassays and Biosensors)
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