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Biosensors Based on Electrical Resistance Measurements

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (15 December 2024) | Viewed by 1149

Special Issue Editor


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Guest Editor
Department of Micro Engineering, Kyoto University, Kyoto, Japan
Interests: microsensors; biosensors; microphysiological systems; micro and nanofabrication; iPSC-derived organoids; electron devices; thermoelectrics; sustainable energy harvesting
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Of late, there has been an increasing demand for microphysiological systems (MPS), as they aim to reduce animal testing and provide a shortcut to clinical trials. In order to screen proper function of these in vitro tools, it essential to miniaturize and integrate biosensors with them in a non-invasive fashion.

Online and on-chip monitoring of transepithelial electric resistance (TEER) can provide an insight into the state of epithelial cells, their imperviousness, and the barrier function. It can also be a measure of drug-induced toxicity.

This Special Issue solicits both review and original research articles related to employing electrical resistance measurement techniques and concepts that realize a wide range of sensing applications. Original papers that put forward novel fabrication technologies, sensing platforms, biological interfacing strategies, microfluidic approaches, cell-based sensing, detection, and quantification of chemicals that pose both physiological and pathological effects, etc., are especially welcome.

Dr. Ramin Banan Sadeghian
Guest Editor

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Keywords

  • electrical resistance measurements
  • microphysiological systems
  • TEER
  • biosensors
  • drug-induced toxicity

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Published Papers (1 paper)

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Research

11 pages, 4753 KiB  
Communication
Pathogenic Bacterial Detection Using Vertical-Capacitance Sensor Array Immobilized with the Antimicrobial Peptide Melittin
by Sun-Mi Lee, Jun-Ho Song, Kyo-Seok Lee and Kyung-Hwa Yoo
Sensors 2025, 25(1), 12; https://doi.org/10.3390/s25010012 - 24 Dec 2024
Viewed by 730
Abstract
The rapid and reliable detection of pathogenic bacteria remains a significant challenge in clinical microbiology. Consequently, the demand for simple and rapid techniques, such as antimicrobial peptide (AMP)-based sensors, has recently increased as an alternative to traditional methods. Melittin, a broad-spectrum AMP, rapidly [...] Read more.
The rapid and reliable detection of pathogenic bacteria remains a significant challenge in clinical microbiology. Consequently, the demand for simple and rapid techniques, such as antimicrobial peptide (AMP)-based sensors, has recently increased as an alternative to traditional methods. Melittin, a broad-spectrum AMP, rapidly associates with the cell membranes of various gram-positive and gram-negative bacteria. It also inhibits bacterial biofilm formation in blood culture media. In our study, bacterial growth was measured using electrical vertical-capacitance sensors with interdigitated electrodes functionalized with melittin, a widely studied AMP. The melittin-immobilized vertical-capacitance sensors demonstrated real-time detection of both standard and clinically isolated bacteria in media. Furthermore, these sensors successfully detected clinically isolated bacteria in blood culture media while inhibiting bacterial biofilm formation. Melittin-immobilized vertical-capacitance sensors provide a rapid and sensitive pathogen detection platform, with significant potential for improving patient care. Full article
(This article belongs to the Special Issue Biosensors Based on Electrical Resistance Measurements)
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