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Electrochemistry in Microfluidics for Early Diagnosis

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A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 7558

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Special Issue Information

Dear Colleagues,

In recent years, major advances in cleanroom micro- and nanotechnology facilities, combined with the strong growth of microfluidic tool developments, have pointed to a revolution in workbench experimental practices in industry, research, and education. Already, microfluidicians, technologists, chemists, and biologists are taking advantage of these recent advances for fundamental or applied broad-spectrum studies ranging, for example, from physics to molecular diagnosis of bacterial and viral diseases. The next critical step is the mastering of the modularity of multiple chemical or physical operations to be implemented in a fully automated laboratory-on-chip (LOC). This development is accelerating by already lifting the constraints imposed by life sciences (analysis time, cost, sample volume, etc.) thanks to the micrometric or even nanometric dimensions of the channels and electrodes. This is especially true for early diagnosis of circulating biomarkers (extraction, separation, concentration, analytical detection, etc.) in the context of liquid biopsy using microfluidics where kinetics of charge transfer at microelectrodes are crucial points.

In this Special Issue, we seek to bring together the latest developments in micro nanofluidics engineering devices and their applications in electrochemistry and/or bioelectrochemistry. For instance, submissions that describe fundamental understanding of mass transfer, transport phenomena at micro nanoscale, and reaction kinetics at micro nanoelectrodes which are crucial points for microfuidics in early medical diagnostic (sample processing and electrochemical detection of biomarkers) are welcomed.

Dr. Jean Gamby
Guest Editor

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Keywords

Electrochemistry
Micro nanofluidics
Early diagnosis
Liquid biopsy

Published Papers (2 papers)

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Research

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18 pages, 4339 KiB

Open AccessArticle

Release and Detection of microRNA by Combining Magnetic Hyperthermia and Electrochemistry Modules on a Microfluidic Chip

by Marie-Charlotte Horny, Vincent Dupuis, Jean-Michel Siaugue and Jean Gamby

Sensors 2021, 21(1), 185; https://doi.org/10.3390/s21010185 - 29 Dec 2020

Cited by 8 | Viewed by 2659

Abstract

The heating of a biologic solution is a crucial part in an amplification process such as the catalytic detection of a biological target. However, in many situations, heating must be limited in microfluidic devices, as high temperatures can cause the denaturation of the chip components. Local heating through magnetic hyperthermia on magnetic nano-objects has opened the doors to numerous improvements, such as for oncology where a reduced heating allows the synergy of chemotherapy and thermotherapy. Here we report on the design and implementation of a lab on chip without global heating of samples. It takes advantage of the extreme efficiency of DNA-modified superparamagnetic core–shell nanoparticles to capture complementary sequences (microRNA-target), uses magnetic hyperthermia to locally release these targets, and detects them through electrochemical techniques using ultra-sensitive channel DNA-modified ultramicroelectrodes. The combination of magnetic hyperthermia and microfluidics coupled with on-chip electrochemistry opens the way to a drastic reduction in the time devoted to the steps of extraction, amplification and nucleic acids detection. The originality comes from the design and microfabrication of the microfluidic chip suitable to its insertion in the millimetric gap of toric inductance with a ferrite core. Full article

(This article belongs to the Special Issue Electrochemistry in Microfluidics for Early Diagnosis)

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Review

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28 pages, 4543 KiB

Open AccessReview

Electrochemical Detection and Point-of-Care Testing for Circulating Tumor Cells: Current Techniques and Future Potentials

by Chunyang Lu, Jintao Han, Xiaoyi Sun and Gen Yang

Sensors 2020, 20(21), 6073; https://doi.org/10.3390/s20216073 - 26 Oct 2020

Cited by 12 | Viewed by 4416

Abstract

Circulating tumor cells (CTCs) are tumor cells that escaped from the primary tumor or the metastasis into the blood and they play a major role in the initiation of metastasis and tumor recurrence. Thus, it is widely accepted that CTC is the main target of liquid biopsy. In the past few decades, the separation of CTC based on the electrochemical method has attracted widespread attention due to its convenience, rapidness, low cost, high sensitivity, and no need for complex instruments and equipment. At present, CTC detection is not widely used in the clinic due to various reasons. Point-of-care CTC detection provides us with a possibility, which is sensitive, fast, cheap, and easy to operate. More importantly, the testing instrument is small and portable, and the testing does not require specialized laboratories and specialized clinical examiners. In this review, we summarized the latest developments in the electrochemical-based CTC detection and point-of-care CTC detection, and discussed the challenges and possible trends. Full article

(This article belongs to the Special Issue Electrochemistry in Microfluidics for Early Diagnosis)

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