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Biosensors for Theranostics
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Biosensors for Theranostics

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (15 May 2018) | Viewed by 10564

Special Issue Editors

Prof. Dr. Pedro Viana Baptista

E-Mail Website
Guest Editor
UCIBIO, Department of Life Sciences, Faculdade de Ciencias e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal
Interests: anomedicine; application of DNA/RNA systems for nanobiotechnology; biosensing; molecular diagnostics and therapeutics; advanced drug delivery systems; gene silencing
Special Issues, Collections and Topics in MDPI journals
Dr. Alexandra R. Fernandes

E-Mail Website
Guest Editor
UCIBIO, Department of Life Sciences, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal
Interests: cancer diagnostics; 2D and 3D models for cancer studies; mechanisms-of-action of novel drugs; immortalization of cell lines from patients; proteomics; drug delivery

Special Issue Information

Dear Colleagues,

(Nano)Theranostics effectively brings together diagnostics and therapeutics onto a single platform, making them powerful tools in biomedicine. This even more true when using nanoscale structures, of which optical, (eletro)chemical and biological properties make them optimal biosensing transducers for theranostics agents. When designing a nanotheranostics, one should take into consideration: i) the choice of most suitable nanocarrier for effective delivery for tissue delivery and cell internalization; ii) the effector molecule, from standard drugs to nucleic acids; iii) to ensure controlled release of effector molecule; iv) the signal  transducer (e.g. imaging) component that allows for the real time monitoring of the nanoconjugate location and effect on target tissue cells; and v) an active targeting agent, typically a cell-surface marker or an oligonucleotide, that maximizes specificity of the vector and minimizes damages to healthy cells.

This Special Issue aims to highlight recent advances in the development of novel biosensing schemes and strategies that potentiate and enhance the performance of (nano)theranostics applications with a strong focus on those suitable for translation to the clinics.

Prof. Dr. Pedro Viana Baptista
Dr. Alexandra Fernandes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biosensor
  • Theranostics
  • DNA
  • RNA
  • Gene expression
  • Drug delivery
  • Imaging

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Published Papers (2 papers)

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16 pages, 1628 KiB  
Article
Peptide-Cellulose Conjugates on Cotton-Based Materials Have Protease Sensor/Sequestrant Activity
by J. Vincent Edwards, Krystal R. Fontenot, Falk Liebner and Brian D. Condon
Sensors 2018, 18(7), 2334; https://doi.org/10.3390/s18072334 - 18 Jul 2018
Cited by 20 | Viewed by 3803
Abstract
The growing incidence of chronic wounds in the world population has prompted increased interest in chronic wound dressings with protease-modulating activity and protease point of care sensors to treat and enable monitoring of elevated protease-based wound pathology. However, the overall design features needed [...] Read more.
The growing incidence of chronic wounds in the world population has prompted increased interest in chronic wound dressings with protease-modulating activity and protease point of care sensors to treat and enable monitoring of elevated protease-based wound pathology. However, the overall design features needed for the combination of a chronic wound dressing that lowers protease activity along with protease detection capability as a single platform for semi-occlusive dressings has scarcely been addressed. The interface of dressing and sensor specific properties (porosity, permeability, moisture uptake properties, specific surface area, surface charge, and detection) relative to sensor bioactivity and protease sequestrant performance is explored here. Measurement of the material’s zeta potential demonstrated a correlation between negative charge and the ability of materials to bind positively charged Human Neutrophil Elastase. Peptide-cellulose conjugates as protease substrates prepared on a nanocellulosic aerogel were assessed for their compatibility with chronic wound dressing design. The porosity, wettability and absorption capacity of the nanocellulosic aerogel were consistent with values observed for semi-occlusive chronic wound dressing designs. The relationship of properties that effect dressing functionality and performance as well as impact sensor sensitivity are discussed in the context of the enzyme kinetics. The sensor sensitivity of the aerogel-based sensor is contrasted with current clinical studies on elastase. Taken together, comparative analysis of the influence of molecular features on the physical properties of three forms of cellulosic transducer surfaces provides a meaningful assessment of the interface compatibility of cellulose-based sensors and corresponding protease sequestrant materials for potential use in chronic wound sensor/dressing design platforms. Full article
(This article belongs to the Special Issue Biosensors for Theranostics)
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15 pages, 2844 KiB  
Article
Hyperpolarized Amino Acid Derivatives as Multivalent Magnetic Resonance pH Sensor Molecules
by Christian Hundshammer, Stephan Düwel, David Ruseckas, Geoffrey Topping, Piotr Dzien, Christoph Müller, Benedikt Feuerecker, Jan B. Hövener, Axel Haase, Markus Schwaiger, Steffen J. Glaser and Franz Schilling
Sensors 2018, 18(2), 600; https://doi.org/10.3390/s18020600 - 15 Feb 2018
Cited by 28 | Viewed by 5859
Abstract
pH is a tightly regulated physiological parameter that is often altered in diseased states like cancer. The development of biosensors that can be used to non-invasively image pH with hyperpolarized (HP) magnetic resonance spectroscopic imaging has therefore recently gained tremendous interest. However, most [...] Read more.
pH is a tightly regulated physiological parameter that is often altered in diseased states like cancer. The development of biosensors that can be used to non-invasively image pH with hyperpolarized (HP) magnetic resonance spectroscopic imaging has therefore recently gained tremendous interest. However, most of the known HP-sensors have only individually and not comprehensively been analyzed for their biocompatibility, their pH sensitivity under physiological conditions, and the effects of chemical derivatization on their logarithmic acid dissociation constant (pKa). Proteinogenic amino acids are biocompatible, can be hyperpolarized and have at least two pH sensitive moieties. However, they do not exhibit a pH sensitivity in the physiologically relevant pH range. Here, we developed a systematic approach to tailor the pKa of molecules using modifications of carbon chain length and derivatization rendering these molecules interesting for pH biosensing. Notably, we identified several derivatives such as [1-13C]serine amide and [1-13C]-2,3-diaminopropionic acid as novel pH sensors. They bear several spin-1/2 nuclei (13C, 15N, 31P) with high sensitivity up to 4.8 ppm/pH and we show that 13C spins can be hyperpolarized with dissolution dynamic polarization (DNP). Our findings elucidate the molecular mechanisms of chemical shift pH sensors that might help to design tailored probes for specific pH in vivo imaging applications. Full article
(This article belongs to the Special Issue Biosensors for Theranostics)
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