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Biosensing Systems for Point-of-Care Diagnostics

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A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (1 March 2021)

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Special Issue Editor

Prof. Dr. Seokheun Choi

E-Mail Website
Guest Editor

Bioelectronics & Microsystems Laboratory, Department of Electrical & Computer Engineering, State University of New York-Binghamton, Binghamton, NY 13902, USA
Interests: bioelectronics and microsystems; biomems/nems; microfluidics; semiconductors; biosensors and biofuel cells; bioenergy; nanotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Effective and rapid point-of-care (POC) diagnostics have the capability to revolutionize public healthcare both in developed and developing countries. POC testing can provide in-vitro diagnostics and immediately actionable healthcare information at accident sites, in doctors’ offices, and in ambulances. POC tests can also, potentially, allow patients to self-test and self-manage care at their homes, which is especially useful for stigmatized conditions, such as sexually transmitted diseases and HIV/AIDS.

A recent advance in molecular biology and bioMEMS has greatly enhanced the analytical performance of POC diagnostics and, as a result, numerous new POC applications have been proposed. These advances are reflected in an increasing number of scientific publications, patents and commercial products that demonstrate high sensitivity, selectivity and reliability, as well as fast, accurate, cost-effective and user-friendly assays. However, several key challenges remain and must be addressed to realize a truly stand-alone biosensing system that does not rely on a competent laboratory service. The challenges involve developing quality assessment, system integration, and data management solutions.

On this research topic, we welcome review articles and original research papers aiming to the related key issues of basic research, materials development, system integration and data management with new POC diagnostic technologies in the frame of emerging and demanding biotechnological applications.

Prof. Dr. Seokheun Choi
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Point-of-care diagnostics
Lab-on-Chip
BioMEMS
Biosensing systems
Bioelectronics
Power sources
Data management and machine learning
Paper-based diagnostics
Smartphone-based diagnostics
Wearable diagnostics
Self-powered biosensors
New sensing methods and technologies
Micro-/nano-system design, fabrication, and materials

Published Papers (3 papers)

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Research

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16 pages, 2297 KiB

Open AccessArticle

An Affordable Method for Evaluation of Ataxic Disorders Based on Electrooculography

by Alberto López, Francisco Ferrero and Octavian Postolache

Sensors 2019, 19(17), 3756; https://doi.org/10.3390/s19173756 - 30 Aug 2019

Cited by 13 | Viewed by 3945

Abstract

Ataxias are a group of neurodegenerative disorders characterized by cerebellar dysfunction that cause irregularities in the rate, rhythm, amplitude, and force of voluntary movements. The electrooculogram (EOG) may provide clues about ataxic disorders because most of these patients have difficulty with visual tracking and fixing their gaze. Using electrodes, EOG records the biopotentials generated by eye movements. In this paper, three surface electrodes are placed around the eye socket, and the biopotentials generated by eye movements are acquired using a commercial bioamplifier device. Next, the signals are sent to the computer to be digitally processed to extract the rate of saccades as well as the delay and deviation of the gaze in response to a stimulus. These features are analysed in a novel software application designed to help physicians in evaluating ataxia. After applying several tests to both healthy and ataxia-affected patients, differences in EOG results were found. The evaluation of the reliability of the designed software application is made according to three metrics: sensitivity, specificity, and accuracy. The results indicate the proposed system’s viability as an affordable method for evaluation of ataxic disorders. Full article

(This article belongs to the Special Issue Biosensing Systems for Point-of-Care Diagnostics)

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15 pages, 4410 KiB

Open AccessArticle

Self-Powered Portable Electronic Reader for Point-of-Care Amperometric Measurements

by Yaiza Montes-Cebrián, Albert Álvarez-Carulla, Jordi Colomer-Farrarons, Manel Puig-Vidal and Pere Ll. Miribel-Català

Sensors 2019, 19(17), 3715; https://doi.org/10.3390/s19173715 - 27 Aug 2019

Cited by 6 | Viewed by 3803

Abstract

In this work, we present a self-powered electronic reader (e-reader) for point-of-care diagnostics based on the use of a fuel cell (FC) which works as a power source and as a sensor. The self-powered e-reader extracts the energy from the FC to supply the electronic components concomitantly, while performing the detection of the fuel concentration. The designed electronics rely on straightforward standards for low power consumption, resulting in a robust and low power device without needing an external power source. Besides, the custom electronic instrumentation platform can process and display fuel concentration without requiring any type of laboratory equipment. In this study, we present the electronics system in detail and describe all modules that make up the system. Furthermore, we validate the device’s operation with different emulated FCs and sensors presented in the literature. The e-reader can be adjusted to numerous current ranges up to 3 mA, with a 13 nA resolution and an uncertainty of 1.8%. Besides, it only consumes 900 µW in the low power mode of operation, and it can operate with a minimum voltage of 330 mV. This concept can be extended to a wide range of fields, from biomedical to environmental applications. Full article

(This article belongs to the Special Issue Biosensing Systems for Point-of-Care Diagnostics)

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Review

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21 pages, 2642 KiB

Open AccessReview

Point-of-Care Diagnostics in Coagulation Management

by Sebastian D. Sahli, Julian Rössler, David W. Tscholl, Jan-Dirk Studt, Donat R. Spahn and Alexander Kaserer

Sensors 2020, 20(15), 4254; https://doi.org/10.3390/s20154254 - 30 Jul 2020

Cited by 27 | Viewed by 6016

Abstract

This review provides a comprehensive and up-to-date overview of point-of-care (POC) devices most commonly used for coagulation analyses in the acute settings. Fast and reliable assessment of hemostasis is essential for the management of trauma and other bleeding patients. Routine coagulation assays are not designed to visualize the process of clot formation, and their results are obtained only after 30–90 m due to the requirements of sample preparation and the analytical process. POC devices such as viscoelastic coagulation tests, platelet function tests, blood gas analysis and other coagulometers provide new options for the assessment of hemostasis, and are important tools for an individualized, goal-directed, and factor-based substitution therapy. We give a detailed overview of the related tests, their characteristics and clinical implications. This review emphasizes the evident advantages of the speed and predictive power of POC clot measurement in the context of a goal-directed and algorithm-based therapy to improve the patient’s outcome. Interpretation of viscoelastic tests is facilitated by a new visualization technology. Full article

(This article belongs to the Special Issue Biosensing Systems for Point-of-Care Diagnostics)

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