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Surface Plasmon Resonance Sensors for Biomedical Detection Application

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Optical Sensors".

Deadline for manuscript submissions: 25 February 2026 | Viewed by 348

Special Issue Editors


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Guest Editor
1. Institute of Optical Materials and Technologies, Bulgarian Academy of Sciences, 109, Acad. G. Bonchev Str., 1113 Sofia, Bulgaria
2. Central Laboratory for Applied Physics, Bulgarian Academy of Sciences, 61 Sanct Petersburg Blvd, 4000 Plovdiv, Bulgaria
Interests: optical sensing; nonlinear optics; fiber optics; applied optics; optical physics; optics; plasmonics; optics and photonics; thin films

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Guest Editor
1. Central Laboratory for Applied Physics, Bulgarian Academy of Sciences, 61 Sanct Petersburg Blvd, 4000 Plovdiv, Bulgaria
2. Centre de Recherche en Photonique, Université du Québec en Outaouais, 101 rue Saint-Jean-Bosco, Gatineau, QC J8X 3X7, Canada
Interests: polarization matrix methods; optical fibers; fiber optic sensors and components; sensor interrogation instrumentation and fluorescence studies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Surface plasmon resonance (SPR) has firmly established itself as a reliable method for the label-free detection of biomolecular interactions, with significant application in biomedical diagnostics. The primary objective of this Special Issue is to review state-of-the-art innovative approaches and advanced tools for improved SPR detection in biomedical research. The second objective is to elucidate the clinical detection features of targets in complex matrices, such as blood, serum, urine, stool, or saliva, including immobilization methods, choice of recognition agent, and clinical sample pretreatment. This will highlight promising avenues for method improvement to achieve increased sensitivity and accuracy in biomedical detection.

The topics of interest include, but are not limited to, the following:

  • Kretschmann/grating-based SPR sensors, specifically recent achievements applied to biomedical diagnostics;
  • SPR imaging biosensors for protein/biomarker detection in clinical samples;
  • Two-dimensional material-based SPR sensors for biomedical diagnostics;
  • Bioreceptor immobilization assay format;
  • Hormone/biomarker/pathogen SPR detection.

Dr. Georgi Dyankov
Dr. Tinko Eftimov
Guest Editors

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Keywords

  • grating/prism-based SPR
  • SPRi biosensor
  • optical fiber-based SPR sensors
  • two-dimensional nanomaterials for SPR-based biosensors
  • molecular diagnostic
  • clinical samples
  • SPR immunosensor
  • nanoparticles

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Published Papers (1 paper)

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Research

17 pages, 3355 KiB  
Article
Model Design and Study of a U-Channel Photonic Crystal Fib Optic Sensor for Measuring Glucose Concentration in Blood
by Lei Zhao, Hua Yang, Tangyou Sun, Qianju Song, Zao Yi and Yougen Yi
Sensors 2025, 25(9), 2647; https://doi.org/10.3390/s25092647 - 22 Apr 2025
Viewed by 271
Abstract
This research introduces a biosensor utilizing surface plasmon resonance in a photonic crystal fiber (PCF) configuration. PCF uses fused silica as the base material, with a layer of gold placed over the U-channels in the cross-section of the fiber to create a surface [...] Read more.
This research introduces a biosensor utilizing surface plasmon resonance in a photonic crystal fiber (PCF) configuration. PCF uses fused silica as the base material, with a layer of gold placed over the U-channels in the cross-section of the fiber to create a surface plasmon resonance. There are three different sizes of internal fiber optic air hole diameters, with a larger channel circle below the u-channel for the formation of an energy leakage window. COMSOL software 6.0 assisted us in tuning the fiber optic structure and performance for the study, and the structural parameters analyzed mainly include the channel circle diameter, the channel circle spacing, the profundity measurement of the polished layer, and the nanoscale size variation of metal films. The results of the simulation study show that the optical fiber sensor achieves refractive index (RI) responsiveness across the 1.30 to 1.41 range, and in the RI interval of 1.40 to 1.41, the sensor exhibits the largest resonance peak shift, and its highest sensitivity reaches 10,200 nm/RIU, and the smallest full width at half peak (FWHM) corresponds to the RI of 1.34 with a value of 4.8 nm, and the highest figure of merit (FOM) corresponds to the RI of 1.34 with a value of 895.83 (1/RIU). COMSOL 6.0 simulation software, was used to simulate the changes in blood refractive index corresponding to different glucose concentrations, and the detection performance of the sensor for different concentrations of glucose was tested. Then, the results show that the glucose concentration in 75 mg/dL–175 mg/dL with RI detection sensitivity is 3750 nm/RIU, where the maximum refractive index sensitivity is 5455 nm/RIU. It shows that the sensor can be applied in the field of biomedical applications, with its convenience, fast response, and high sensitivity, it has great potential and development prospect in the market. Full article
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