Special Issue "New Insights into Drug Delivery and Absorption"

A special issue of Scientia Pharmaceutica (ISSN 2218-0532).

Deadline for manuscript submissions: 31 May 2019

Special Issue Editor

Guest Editor
Prof. Dr. Miklós Vecsernyés

Faculty of Pharmacy, University of Debrecen, Hungary
E-Mail
Interests: drug absorption processes; cyclodextrins; barrier systems; endocrine systems

Special Issue Information

Dear Colleagues,

Reaching the desired concentration of the active ingredient in a target area is a great challenge in the therapeutic field. In order to influence this process, we can choose from many different pharmaceutical technological formulations. However, find the optimal route of administration is also crucial for the drug delivery system. It is also a great challenge for the active agent to get through barrier systems in the body (like blood-brain- barrier, or skin).

This Special Issue, entitled "New Insights into Drug Delivery and Absorption”, collects publications regarding current developments in drug delivery systems according to the area of the administration of given active ingredients. This collection will help readers gain a knowledge of the field of drug delivery systems and the main delivery gates of the body, while also providing an overview of the field.

Prof. Dr. Miklós Vecsernyés
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Scientia Pharmaceutica is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 850 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery
  • cyclodextrins
  • nanoemulsions
  • microemulsions
  • drug absorption from GI tract
  • blood-brain barrier
  • transdermal drug delivery
  • ocular drug delivery

Published Papers (1 paper)

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Review

Open AccessReview Overcoming the Blood–Brain Barrier. Challenges and Tricks for CNS Drug Delivery
Sci. Pharm. 2019, 87(1), 6; https://doi.org/10.3390/scipharm87010006
Received: 26 January 2019 / Revised: 22 February 2019 / Accepted: 26 February 2019 / Published: 28 February 2019
PDF Full-text (2255 KB) | HTML Full-text | XML Full-text
Abstract
Treatment of certain central nervous system disorders, including different types of cerebral malignancies, is limited by traditional oral or systemic administrations of therapeutic drugs due to possible serious side effects and/or lack of the brain penetration and, therefore, the efficacy of the drugs [...] Read more.
Treatment of certain central nervous system disorders, including different types of cerebral malignancies, is limited by traditional oral or systemic administrations of therapeutic drugs due to possible serious side effects and/or lack of the brain penetration and, therefore, the efficacy of the drugs is diminished. During the last decade, several new technologies were developed to overcome barrier properties of cerebral capillaries. This review gives a short overview of the structural elements and anatomical features of the blood–brain barrier. The various in vitro (static and dynamic), in vivo (microdialysis), and in situ (brain perfusion) blood–brain barrier models are also presented. The drug formulations and administration options to deliver molecules effectively to the central nervous system (CNS) are presented. Nanocarriers, nanoparticles (lipid, polymeric, magnetic, gold, and carbon based nanoparticles, dendrimers, etc.), viral and peptid vectors and shuttles, sonoporation and microbubbles are briefly shown. The modulation of receptors and efflux transporters in the cell membrane can also be an effective approach to enhance brain exposure to therapeutic compounds. Intranasal administration is a noninvasive delivery route to bypass the blood–brain barrier, while direct brain administration is an invasive mode to target the brain region with therapeutic drug concentrations locally. Nowadays, both technological and mechanistic tools are available to assist in overcoming the blood–brain barrier. With these techniques more effective and even safer drugs can be developed for the treatment of devastating brain disorders. Full article
(This article belongs to the Special Issue New Insights into Drug Delivery and Absorption)
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