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Open AccessReview

Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers

1
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary
2
Doctoral School of Pharmaceutical Sciences, University of Debrecen, H-4032 Debrecen, Hungary
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Sci. Pharm. 2019, 87(4), 33; https://doi.org/10.3390/scipharm87040033 (registering DOI)
Received: 24 September 2019 / Revised: 3 November 2019 / Accepted: 13 November 2019 / Published: 20 November 2019
(This article belongs to the Special Issue New Insights into Drug Delivery and Absorption)
Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic. This enables them for the complex formation with lipophilic molecules. They have several applications in the pharmaceutical field like solubility enhancers or the building blocks of larger drug delivery systems. On the other hand, they have numerous effects on cells or biological barriers. In this review the most important properties of cyclodextrins and cyclodextrin-based drug delivery systems are summarized with special focus on their biological activity. View Full-Text
Keywords: cyclodextrins; drug delivery systems; biological barriers; nanopharmaceutics cyclodextrins; drug delivery systems; biological barriers; nanopharmaceutics
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Haimhoffer, Á.; Rusznyák, Á.; Réti-Nagy, K.; Vasvári, G.; Váradi, J.; Vecsernyés, M.; Bácskay, I.; Fehér, P.; Ujhelyi, Z.; Fenyvesi, F. Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers. Sci. Pharm. 2019, 87, 33.

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