Cyclodextrins in Drug Delivery Systems and their Effects on Biological Barriers
by
Ádám Haimhoffer 1,2,†, Ágnes Rusznyák 1,2,†, Katalin Réti-Nagy 1, Gábor Vasvári 1,2, Judit Váradi 1, Miklós Vecsernyés 1, Ildikó Bácskay 1, Pálma Fehér 1, Zoltán Ujhelyi 1 and Ferenc Fenyvesi 1,*
Ádám Haimhoffer 1,2,†, Ágnes Rusznyák 1,2,†, Katalin Réti-Nagy 1, Gábor Vasvári 1,2, Judit Váradi 1, Miklós Vecsernyés 1, Ildikó Bácskay 1, Pálma Fehér 1, Zoltán Ujhelyi 1 and Ferenc Fenyvesi 1,*
1
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary
2
Doctoral School of Pharmaceutical Sciences, University of Debrecen, H-4032 Debrecen, Hungary
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Sci. Pharm. 2019, 87(4), 33; https://doi.org/10.3390/scipharm87040033
Received: 24 September 2019 / Revised: 3 November 2019 / Accepted: 13 November 2019 / Published: 20 November 2019
(This article belongs to the Special Issue New Insights into Drug Delivery and Absorption)
Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic. This enables them for the complex formation with lipophilic molecules. They have several applications in the pharmaceutical field like solubility enhancers or the building blocks of larger drug delivery systems. On the other hand, they have numerous effects on cells or biological barriers. In this review the most important properties of cyclodextrins and cyclodextrin-based drug delivery systems are summarized with special focus on their biological activity.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Haimhoffer, Á.; Rusznyák, Á.; Réti-Nagy, K.; Vasvári, G.; Váradi, J.; Vecsernyés, M.; Bácskay, I.; Fehér, P.; Ujhelyi, Z.; Fenyvesi, F. Cyclodextrins in Drug Delivery Systems and their Effects on Biological Barriers. Sci. Pharm. 2019, 87, 33.
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