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Stimulus-Responsive Materials for Biomedical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 9724

Special Issue Editors


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Guest Editor
Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA
Interests: shape memory polymers (SMPs); “smart” materials that are capable of shape change

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Guest Editor
Shape Memory Medical Inc., Santa Clara, CA 95054, USA
Interests: shape memory polymers; material characterization; implantable materials; device development

Special Issue Information

Dear Colleagues,

Shape memory polymers and alloys have maintained a strong presence and utility in industrial and medical applications for decades. Their ability to maintain a programmable shape for long durations and stimulated recovery are desirable for a variety of applications, especially in medical device optimization and tissue engineering. Furthermore, these smart materials can be fabricated into different geometries including soft and hard foams, electrospun meshes, films, and 3D printed matrices. This Special Issue on “Stimulus-Responsive Materials for Biomedical Applications” focuses on the synthesis and design challenges of developing shape memory material structures and their potential use in medical therapies and tissue engineering. Original research and comprehensive reviews pertaining to existing and newly developed shape memory polymers and alloys for medical applications are appreciated. Aspects of medical device design and development such as material synthesis and characterization, device design, device performance evaluation, biocompatibility, biodegradation, and patient output will be explored with the only requirement being that the study motivation involve stimulus-responsive materials. 

Prof. Dr. Duncan J. Maitland
Dr. Sayyeda Marziya Hasan
Guest Editors

Manuscript Submission Information

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Keywords

  • shape memory polymers
  • stimulus-responsive materials
  • material characterization
  • shape memory alloys
  • device design
  • tissue engineering
  • implantable polymers
  • biocompatibility
  • biodegradation
  • device performance

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Published Papers (2 papers)

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Review

43 pages, 4216 KiB  
Review
Application of Nano-Inspired Scaffolds-Based Biopolymer Hydrogel for Bone and Periodontal Tissue Regeneration
by Sheikha A. Alkhursani, Mohamed Mohamady Ghobashy, Samera Ali Al-Gahtany, Abeer S. Meganid, Shady M. Abd El-Halim, Zubair Ahmad, Farhat S. Khan, Gamal Abdel Nasser Atia and Simona Cavalu
Polymers 2022, 14(18), 3791; https://doi.org/10.3390/polym14183791 - 10 Sep 2022
Cited by 26 | Viewed by 5527
Abstract
This review’s objectives are to provide an overview of the various kinds of biopolymer hydrogels that are currently used for bone tissue and periodontal tissue regeneration, to list the advantages and disadvantages of using them, to assess how well they might be used [...] Read more.
This review’s objectives are to provide an overview of the various kinds of biopolymer hydrogels that are currently used for bone tissue and periodontal tissue regeneration, to list the advantages and disadvantages of using them, to assess how well they might be used for nanoscale fabrication and biofunctionalization, and to describe their production processes and processes for functionalization with active biomolecules. They are applied in conjunction with other materials (such as microparticles (MPs) and nanoparticles (NPs)) and other novel techniques to replicate physiological bone generation more faithfully. Enhancing the biocompatibility of hydrogels created from blends of natural and synthetic biopolymers can result in the creation of the best scaffold match to the extracellular matrix (ECM) for bone and periodontal tissue regeneration. Additionally, adding various nanoparticles can increase the scaffold hydrogel stability and provide a number of biological effects. In this review, the research study of polysaccharide hydrogel as a scaffold will be critical in creating valuable materials for effective bone tissue regeneration, with a future impact predicted in repairing bone defects. Full article
(This article belongs to the Special Issue Stimulus-Responsive Materials for Biomedical Applications)
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38 pages, 1636 KiB  
Review
Current Advances in Nano-Based and Polymeric Stimuli-Responsive Drug Delivery Targeting the Ocular Microenvironment: A Review and Envisaged Future Perspectives
by Siphokazi B. K. Dludla, Leshasha T. Mashabela, Brian Ng’andwe, Pedzisai A. Makoni and Bwalya A. Witika
Polymers 2022, 14(17), 3580; https://doi.org/10.3390/polym14173580 - 30 Aug 2022
Cited by 7 | Viewed by 3057
Abstract
Optimal vision remains one of the most essential elements of the sensory system continuously threatened by many ocular pathologies. Various pharmacological agents possess the potential to effectively treat these ophthalmic conditions; however, the use and efficacy of conventional ophthalmic formulations is hindered by [...] Read more.
Optimal vision remains one of the most essential elements of the sensory system continuously threatened by many ocular pathologies. Various pharmacological agents possess the potential to effectively treat these ophthalmic conditions; however, the use and efficacy of conventional ophthalmic formulations is hindered by ocular anatomical barriers. Recent novel designs of ophthalmic drug delivery systems (DDS) using nanotechnology show promising prospects, and ophthalmic formulations based on nanotechnology are currently being investigated due to their potential to bypass these barriers to ensure successful ocular drug delivery. More recently, stimuli-responsive nano drug carriers have gained more attention based on their great potential to effectively treat and alleviate many ocular diseases. The attraction is based on their biocompatibility and biodegradability, unique secondary conformations, varying functionalities, and, especially, the stimuli-enhanced therapeutic efficacy and reduced side effects. This review introduces the design and fabrication of stimuli-responsive nano drug carriers, including those that are responsive to endogenous stimuli, viz., pH, reduction, reactive oxygen species, adenosine triphosphate, and enzymes or exogenous stimuli such as light, magnetic field or temperature, which are biologically related or applicable in clinical settings. Furthermore, the paper discusses the applications and prospects of these stimuli-responsive nano drug carriers that are capable of overcoming the biological barriers of ocular disease alleviation and/or treatment for in vivo administration. There remains a great need to accelerate the development of stimuli-responsive nano drug carriers for clinical transition and applications in the treatment of ocular diseases and possible extrapolation to other topical applications such as ungual or otic drug delivery. Full article
(This article belongs to the Special Issue Stimulus-Responsive Materials for Biomedical Applications)
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