Stimuli Responsive Polymeric-Based Electroactive Biomaterials

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 3358

Special Issue Editors


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Guest Editor
Advanced Materials Department, Jožef Stefan Institute, Jamova Cesta 39, 1000 Ljubljana, Slovenia
Interests: piezoelectric biomaterials; antimicrobial nanoparticles; poly-l-lactide; functionalized gold nanoparticles
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Guest Editor
Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia
Interests: polymeric biomaterials; biodegradable polymers; pH- and temperature-sensitive hydrogels; polymeric systems for controlled drug release; antimicrobial polymeric biomaterials; polymeric wound dressings; polymeric scaffolds for tissue regeneration; biological properties of polymeric biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymer science has expanded its interest toward the development of smart materials capable of stimuli responsive behaviour. Electroactive polymers have the ability to transfer electrons/ions under a specific electrical field, acting as excellent stimuli responsive material in several fields of engineering. Beyond straight forward applications such as electronics and sensors of such polymers, scientits have been exploring electroactive polymers to directly deliver electrostimulation to target cells/tissues, to modulate the cell/tissue response by stimulating their environment and control drug delivery. Intrinsically electroactive polymers used in biomaterials include poly[3,4-(ethylenedioxy)thiophene] (PEDOT), polypyrrole (PPy), and polyaniline (PANi). However, their applicability in bioscience is limited due to their poor processability, mechanical properties and biocompatibility requirements. A possible solution to overcome these limitations is to blend the intrisic electroactive polymer with another polymer with favorable biocompatibility and design flexibility. There is a wide range of biocompatible polymers available, including natural- sourced cellulose, silk, fibroin, collagen, keratin, starch, chitin, self-assembled amino acids, as well as bio-synthetic organic piezoelectrics, such as poly-l-lactide (PLLA) and polyhydroxyalkanoates (PHAs). Another solution is to modify these polymers with piezoelectric materials and conductive nanomaterials to create electrically responsive biomaterials.  

This Special Issue titled "Stimuli Responsive Polymeric-Based Electroactive Biomaterials" will focus on the synthesis, characterization, applications and processing of these biomaterials. We also have a special interest concerning the safety use of electroactive biomaterials. 

Scientists are kindly invited to contribute original research articles, review articles and communications. Potential topics include, but are not limited to, the following:

  • Synthesis and characterization of polymeric-based electroactive biomaterials;
  • Piezoelectic scaffolds for tissue engineering ;
  • Polymeric-based electroactive biomaterials for drug delivery;
  • Modified polymeric biomaterials with electrically responsive nanomaterials;
  • Polymeric-based electroactive biomaterials for wound healing;
  • Polymeric-based electroactive biomaterials behaviour under electrostimulation.

Dr. Marija Vukomanović
Prof. Dr. Simonida Tomic
Guest Editors

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Keywords

  • stimuli responsive polymers
  • drug delivery
  • tissue engineering
  • wound healing
  • electrostimulation
  • piezostimulation
  • piezoelectric polymers
  • electrically stimuli-responsive nanomaterials

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Published Papers (2 papers)

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Article
Mineralized Collagen/Polylactic Acid Composite Scaffolds for Load-Bearing Bone Regeneration in a Developmental Model
by Wenbo Zhu, Wenjing Li, Mengxuan Yao, Yan Wang, Wei Zhang, Chao Li, Xiumei Wang, Wei Chen and Hongzhi Lv
Polymers 2023, 15(20), 4194; https://doi.org/10.3390/polym15204194 - 23 Oct 2023
Cited by 3 | Viewed by 1323 | Correction
Abstract
Repairing load-bearing bone defects in children remains a big clinical challenge. Mineralized collagen (MC) can effectively simulate natural bone composition and hierarchical structure and has a good biocompatibility and bone conductivity. Polylactic acid (PLA) is regarded as a gold material because of its [...] Read more.
Repairing load-bearing bone defects in children remains a big clinical challenge. Mineralized collagen (MC) can effectively simulate natural bone composition and hierarchical structure and has a good biocompatibility and bone conductivity. Polylactic acid (PLA) is regarded as a gold material because of its mechanical properties and degradability. In this study, we prepare MC/PLA composite scaffolds via in situ mineralization and freeze-drying. Cell, characterization, and animal experiments compare and evaluate the biomimetic properties and repair effects of the MC/PLA scaffolds. Phalloidin and DAPI staining results show that the MC/PLA scaffolds are not cytotoxic. CCK-8 and scratch experiments prove that the scaffolds are superior to MC and hydroxyapatite (HA)/PLA scaffolds in promoting cell proliferation and migration. The surface and interior of the MC/PLA scaffolds exhibit rich interconnected pore structures with a porosity of ≥70%. The XRD patterns are typical HA waveforms. X-ray, micro-CT, and H&E staining reveal that the defect boundary disappears, new bone tissue grows into MC/PLA scaffolds in a large area, and the scaffolds are degraded after six months of implantation. The MC/PLA composite scaffold has a pore structure and composition similar to cancellous bone, with a good biocompatibility and bone regeneration ability. Full article
(This article belongs to the Special Issue Stimuli Responsive Polymeric-Based Electroactive Biomaterials)
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2 pages, 326 KiB  
Correction
Correction: Zhu et al. Mineralized Collagen/Polylactic Acid Composite Scaffolds for Load-Bearing Bone Regeneration in a Developmental Model. Polymers 2023, 15, 4194
by Wenbo Zhu, Wenjing Li, Mengxuan Yao, Yan Wang, Wei Zhang, Chao Li, Xiumei Wang, Wei Chen and Hongzhi Lv
Polymers 2024, 16(2), 279; https://doi.org/10.3390/polym16020279 - 19 Jan 2024
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Abstract
In the original publication [...] Full article
(This article belongs to the Special Issue Stimuli Responsive Polymeric-Based Electroactive Biomaterials)
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