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Polymers
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Recent Advances in Bioactive Molecules Delivery
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Recent Advances in Bioactive Molecules Delivery

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 5615

Special Issue Editors

Dr. Paula C. Ferreira

E-Mail Website
Guest Editor
Polytechnic Institute of Coimbra, Superior Institute of Engeneering of Coimbra, 3030-199 Coimbra, Portugal
Interests: polymers; biomaterials; drug delivery; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Patrícia Alves

E-Mail Website
Guest Editor
Department of Chemical Engineering, Chemical Process Engineering and Forest Products Research Centre (CIEPQPF), University of Coimbra, 3030-790 Coimbra, Portugal
Interests: surface modification; smart materials; drug delivery; biomaterials; polymers; liposomes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Promising and versatile bioactive molecule-delivery systems can be used to deliver both small-molecule drugs and various classes of biomacromolecules, such as peptides, proteins, plasmid DNA and synthetic oligodeoxynucleotides. Controlled release of bioactive molecules can enhance their efficacy in several areas of intervention, namely pharmaceutical, agriculture, food industry and packaging or even cosmetics.

Drug delivery systems are one of the main issues of interest to the scientific community. Modern approaches from macromolecular chemistry to medical applications such as drug delivery and tissue engineering raise high demands on the design and functionality of the polymers. On the other hand, the incorporation of bioactive molecules in food packaging materials may allow an increase in the shelf life of those products. In the area of agriculture, a lot of interest has been raised by the incorporation and prolonged release of agrochemicals such as pesticides.

In order to achieve these goals, the high demand for polymeric matrices to sustain and control the delivery of such a variety of molecules justifies the increasing investment in the development of such materials.

This issue aims to review the current state-of-the-art concerning bioactive molecule delivery systems and envision future perspectives. The topical subjects to be addressed include: synthetic polymers, natural polymers, bioconjugation of polymers, smart polymers, amphiphilic polymers, bioactive polymers, the dynamics of polymers crossing biological barriers, targeted drug delivery, polymers as drugs, etc. 

Dr. Paula C. Ferreira
Dr. Patrícia Alves
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive molecules delivery
  • controlled release
  • biocompatibility
  • pharmaceutics
  • agriculture
  • targeting
  • polymeric nanocarrier

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Published Papers (3 papers)

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Research

16 pages, 4903 KiB  
Article
Preparation of N-Halamine Gelatin Sponge and Its Application in the Treatment of Skin Infection
by Jiahao Zhu, Jiageng Xue, Huaiying Qin, Yiqing Wang, Yefan Wang, Yidan Cheng, Yingxia Ma, Xiaoyun Zhang, Chenliang Gong and Guanghui Zhao
Polymers 2024, 16(18), 2579; https://doi.org/10.3390/polym16182579 - 12 Sep 2024
Abstract
Nowadays, there has been an increasing research interest into N-halamine compounds due to their wide antimicrobial properties and no drug resistance. Most of the research mainly focuses on small molecular N-halamines, while few studies are on macromolecule N-halamines. In this work, antibacterial N-halamine [...] Read more.
Nowadays, there has been an increasing research interest into N-halamine compounds due to their wide antimicrobial properties and no drug resistance. Most of the research mainly focuses on small molecular N-halamines, while few studies are on macromolecule N-halamines. In this work, antibacterial N-halamine polymer materials based on proteins (GS-Cl) were synthesized with an antibacterial component of oxidative chlorine, a support component of a gelatin sponge. After carrying out systematic characterization, the GS-Cls exhibited well-defined porous morphology and had a high efficiency in the killing of Gram-positive bacteria (E. coli) and Gram-negative bacteria (S. aureus). The loading of oxidative chlorine (Cl+%) could be controlled by changing the NaClO concentrations and chlorination times. The biocompatibility was confirmed as well. In vivo experiments suggested that the GS-Cl sample could effectively promote the healing of skin wounds in mice E. coli and S. aureus infection models. These studies show that proteins can be chlorinated and endowed with antimicrobial properties, which has great application potential in the treatment of bacteria-infected wounds. Full article
(This article belongs to the Special Issue Recent Advances in Bioactive Molecules Delivery)
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23 pages, 9974 KiB  
Article
Dextran-Based Injectable Hydrogel Composites for Bone Regeneration
by Patrícia Alves, Ana Filipa Simão, Mariana F. P. Graça, Marcos J. Mariz, Ilídio J. Correia and Paula Ferreira
Polymers 2023, 15(23), 4501; https://doi.org/10.3390/polym15234501 - 23 Nov 2023
Cited by 4 | Viewed by 1339
Abstract
Currently, bone infections caused by diseases or injuries are a major health issue. In addition, the conventional therapeutic approaches used to treat bone diseases or injuries present several drawbacks. In the area of tissue engineering, researchers have been developing new alternative therapeutic approaches, [...] Read more.
Currently, bone infections caused by diseases or injuries are a major health issue. In addition, the conventional therapeutic approaches used to treat bone diseases or injuries present several drawbacks. In the area of tissue engineering, researchers have been developing new alternative therapeutic approaches, such as scaffolds, to promote the regeneration of injured tissues. Despite the advantages of these materials, most of them require an invasive surgical procedure. To overcome these problems, the main focus of this work was to develop scaffolds for bone regeneration, which can be applied using injectable hydrogels that circumvent the use of invasive procedures, while allowing for bone regeneration. Throughout this work, injectable hydrogels were developed based on a natural polymer, dextran, along with the use of two inorganic compounds, calcium β-triphosphate and nanohydroxyapatite, that aimed to reinforce the mechanical properties of the 3D mesh. The materials were chemically characterized considering the requirements for the intended application: the swelling capacity was evaluated, the degradation rate in a simulated physiological environment was assessed, and compression tests were performed. Furthermore, vancomycin was incorporated into the polymeric matrices to obtain scaffolds with antibacterial performance, and their drug release profile was assessed. The cytotoxic profile of the hydrogels was assessed by an MTS assay, using osteoblasts as model cells. The data obtained demonstrated that dextran-based hydrogels were successfully synthesized, with a drug release profile with an initial burst between 50 and 80% of the drug. The hydrogels possess fair biocompatibility. The swelling capacity showed that the stability of the samples and their degradation profile is compatible with the average time period required for bone regeneration (usually about one month) and have a favorable Young’s modulus (200–300 kPa). The obtained hydrogels are well-suited for bone regeneration applications such as infections that occur during implantation or bone graft substitutes with antibiotics. Full article
(This article belongs to the Special Issue Recent Advances in Bioactive Molecules Delivery)
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18 pages, 1242 KiB  
Article
Alginate Particles for Encapsulation of Phenolic Extract from Spirulina sp. LEB-18: Physicochemical Characterization and Assessment of In Vitro Gastrointestinal Behavior
by Adriana R. Machado, Pedro M. P. Silva, António A. Vicente, Leonor A. Souza-Soares, Ana C. Pinheiro and Miguel A. Cerqueira
Polymers 2022, 14(21), 4759; https://doi.org/10.3390/polym14214759 - 6 Nov 2022
Cited by 11 | Viewed by 3467
Abstract
Encapsulation can be used as a strategy to protect and control the release of bioactive extracts. In this work, an extract from Spirulina sp. LEB-18, rich in phenolic compounds, was encapsulated in biopolymeric particles (i.e., composed of alginate) and characterized concerning their thermal [...] Read more.
Encapsulation can be used as a strategy to protect and control the release of bioactive extracts. In this work, an extract from Spirulina sp. LEB-18, rich in phenolic compounds, was encapsulated in biopolymeric particles (i.e., composed of alginate) and characterized concerning their thermal behavior using differential scanning calorimetry (DSC), size, morphology, swelling index (S), and encapsulation efficiency (EE%); the release profile of the phenolic compounds at different pHs and the particle behavior under in vitro gastrointestinal digestion were also evaluated. It was shown that it is possible to encapsulate the phenolic extract from Spirulina sp. LEB-18 in alginate particles with high encapsulation efficiency (88.97%). It was also observed that the particles are amorphous and that the encapsulated phenolic compounds were released at a pH 7.2 but not at pH 1.5, which means that the alginate particles are able to protect the phenolic compounds from the harsh stomach conditions but lose their integrity under intestinal pH conditions. Regarding bioaccessibility, it was observed that the encapsulated phenolic compounds showed higher bioaccessibility compared to phenolic compounds in free form. This work increases the knowledge about the behavior of alginate particles encapsulating phenolic compounds during in vitro gastrointestinal digestion. It also provides essential information for designing biopolymeric particle formulations encapsulating phenolic compounds for application in pharmaceutical and food products. Full article
(This article belongs to the Special Issue Recent Advances in Bioactive Molecules Delivery)
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