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Polymers
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Study in Chitosan and Crosslinked Chitosan Nanoparticles
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Study in Chitosan and Crosslinked Chitosan Nanoparticles

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (15 November 2024) | Viewed by 7200

Special Issue Editors

Dr. Aldo Amaro-Reyes

E-Mail Website1 Website2
Guest Editor
Departamento de Investigación y Posgrado en Alimentos, Facultad de Química, Universidad Autónoma de Querétaro, Querétaro 76010, Mexico
Interests: biotechnology; nanocomposites; fermentation; bioprocess; water treatment; bioeconomy
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Carlos Regalado-González

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Guest Editor
Departamento de Investigación y Posgrado en Alimentos, Facultad de Química, Universidad Autónoma de Querétaro, Cerro de las Campanas s/n, Col. Las Campanas, Queretaro 76010, Mexico
Interests: active edible films; essential oil; mesoporous silica nanoparticles; nanocellulose; biodegradability; edible coating; chitosan; food preservation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chitosan is a biodegradable polymer derived from chitin, which is found in the exoskeletons of crustaceans. It has a wide range of applications, including as a drug delivery system, wound dressing, and food preservative. Crosslinked chitosan nanoparticles are chitosan nanoparticles with a large surface area that have been treated with a crosslinking agent to increase their stability and durability. Crosslinking can also improve the mechanical properties of the nanoparticles, making them more resistant to degradation by enzymes or pH changes. This increased stability leads to crosslinked chitosan nanoparticles having many potential applications in various industries due to their biocompatibility, biodegradability, and versatility.

Dr. Aldo Amaro-Reyes
Prof. Dr. Carlos Regalado-González
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chitosan
  • crosslinking
  • nanoparticles
  • tissue engineering
  • enzyme immobilization
  • targeted drug delivery
  • genipin
  • glutaraldehyde
  • tripolyphosphate
  • polymer coating
  • nanobiocatalyst

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Published Papers (2 papers)

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Research

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17 pages, 3885 KiB  
Article
Rheological Characterization of Genipin-Based Crosslinking Pigment and O-Carboxymethyl Chitosan–Oxidized Hyaluronic Acid In Situ Formulable Hydrogels
by Ivo Marquis Beserra Junior, Débora de Sousa Lopes, Milena Costa da Silva Barbosa, João Emídio da Silva Neto, Henrique Nunes da Silva, Marcus Vinícius Lia Fook, Rômulo Feitosa Navarro and Suédina Maria de Lima Silva
Polymers 2024, 16(18), 2615; https://doi.org/10.3390/polym16182615 - 15 Sep 2024
Cited by 1 | Viewed by 1673
Abstract
The aim of this study was to develop a material capable of rapidly absorbing bodily fluids and forming a resilient, adhesive, viscoelastic hydrogel in situ to prevent post-surgical adhesions. This material was formulated using O-carboxymethyl chitosan (O-CMCS), oxidized hyaluronic acid (OHA), and a [...] Read more.
The aim of this study was to develop a material capable of rapidly absorbing bodily fluids and forming a resilient, adhesive, viscoelastic hydrogel in situ to prevent post-surgical adhesions. This material was formulated using O-carboxymethyl chitosan (O-CMCS), oxidized hyaluronic acid (OHA), and a crosslinking pigment derived from genipin and glutamic acid (G/GluP). Both crosslinked (O-CMCS/OHA-G/GluP) and non-crosslinked hydrogels (O-CMCS/OHA) were evaluated using a HAAKE™ MARS™ rheometer for their potential as post-surgical barriers. A rheological analysis, including dynamic oscillatory measurements, revealed that the crosslinked hydrogels exhibited significantly higher elastic moduli (G′), indicating superior gel formation and mechanical stability compared to non-crosslinked hydrogels. The G/GluP crosslinker enhanced gel stability by increasing the separation between G′ and G″ and achieving a lower loss tangent (tan δ < 1.0), indicating robustness under dynamic physiological conditions. The rapid hydration and gelation properties of the hydrogels underscore their effectiveness as physical barriers. Furthermore, the O-CMCS/OHA-G/GluP hydrogel demonstrated rapid self-healing and efficient application via spraying or spreading, with tissue adherence and viscoelasticity to facilitate movement between tissues and organs, effectively preventing adhesions. Additionally, the hydrogel proved to be both cost effective and scalable, highlighting its potential for clinical applications aimed at preventing post-surgical adhesions. Full article
(This article belongs to the Special Issue Study in Chitosan and Crosslinked Chitosan Nanoparticles)
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Review

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28 pages, 4110 KiB  
Review
Advancements in Chitosan-Based Nanoparticles for Pulmonary Drug Delivery
by Thiago Medeiros Zacaron, Mariana Leite Simões e Silva, Mirsiane Pascoal Costa, Dominique Mesquita e Silva, Allana Carvalho Silva, Ana Carolina Morais Apolônio, Rodrigo Luiz Fabri, Frederico Pittella, Helvécio Vinícius Antunes Rocha and Guilherme Diniz Tavares
Polymers 2023, 15(18), 3849; https://doi.org/10.3390/polym15183849 - 21 Sep 2023
Cited by 22 | Viewed by 4817
Abstract
The evolution of respiratory diseases represents a considerable public health challenge, as they are among the leading causes of death worldwide. In this sense, in addition to the high prevalence of diseases such as asthma, chronic obstructive pulmonary disease, pneumonia, cystic fibrosis, and [...] Read more.
The evolution of respiratory diseases represents a considerable public health challenge, as they are among the leading causes of death worldwide. In this sense, in addition to the high prevalence of diseases such as asthma, chronic obstructive pulmonary disease, pneumonia, cystic fibrosis, and lung cancer, emerging respiratory diseases, particularly those caused by members of the coronavirus family, have contributed to a significant number of deaths on a global scale over the last two decades. Therefore, several studies have been conducted to optimize the efficacy of treatments against these diseases, focusing on pulmonary drug delivery using nanomedicine. Thus, the development of nanocarriers has emerged as a promising alternative to overcome the limitations of conventional therapy, by increasing drug bioavailability at the target site and reducing unwanted side effects. In this context, nanoparticles composed of chitosan (CS) show advantages over other nanocarriers because chitosan possesses intrinsic biological properties, such as anti-inflammatory, antimicrobial, and mucoadhesive capacity. Moreover, CS nanoparticles have the potential to enhance drug stability, prolong the duration of action, improve drug targeting, control drug release, optimize dissolution of poorly soluble drugs, and increase cell membrane permeability of hydrophobic drugs. These properties could optimize the performance of the drug after its pulmonary administration. Therefore, this review aims to discuss the potential of chitosan nanoparticles for pulmonary drug delivery, highlighting how their biological properties can improve the treatment of pulmonary diseases, including their synergistic action with the encapsulated drug. Full article
(This article belongs to the Special Issue Study in Chitosan and Crosslinked Chitosan Nanoparticles)
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