Advances in Diffuse Optical Tomography: Current Trends and Future Perspectives

Dear Colleagues,

Diffuse optical tomography (DOT) has emerged as a powerful imaging modality that uses visible and near-infrared light to probe biological tissues noninvasively. It provides a three-dimensional image of physiologically important biomarkers and has gained an increasing prominence in biomedical science, diagnostics, treatment monitoring, and therapy.

This Special Issue aims to provide a comprehensive platform for researchers and clinicians to showcase their latest findings, advancements, and innovations in DOT technology and its applications. We invite contributions that explore the fundamental principles, technical advancements, clinical applications, and future directions of DOT, fostering interdisciplinary collaborations and advancing the field as a whole.

We are seeking high-quality original research articles, review papers, case studies, and short communications that address, but are not limited to, the following topics:

Fundamentals and Methodological Developments:

• Novel algorithms and computational methods for DOT image reconstruction.
• Advancements in light–tissue interaction models and simulations.
• Improved data acquisition techniques and instrumentation.

Clinical Applications:

• DOT in the early detection and diagnosis of cancer.
• Monitoring of brain function and neurodegenerative diseases.
• Assessment of tissue oxygenation, perfusion, and metabolism.
• Therapeutic response monitoring in oncology and other medical conditions.

Translational Research:

• Bridging the gap between preclinical and clinical DOT studies.
• Standardization and validation of DOT measurements.
• Multimodal imaging approaches combining DOT with other modalities (e.g., MRI, CT, PET).

Emerging Trends and Future Directions:

• Novel biomarkers and targets for DOT imaging.
• Integration of DOT with artificial intelligence and machine learning.
• Portable and wearable DOT systems for point-of-care diagnostics.

Dr. Limin Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Photonics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• biomedical optical imaging
• light propagation model
• image reconstruction
• optical measurement technique
• medical applications of diffuse light