Protein-Based Biosensors and Biomaterials for Diagnostic Application and Drug Discovery

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 6151

Special Issue Editors


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Guest Editor
Department of Biology and Interdisciplinary Neuroscience Program, Syracuse University, Syracuse, NY, USA
Interests: intrinsically disordered protein; oligomerization; aggregation; protein-protein interaction; fluorescence resonance energy transfer (FRET); high-throughput screening; neuroinflammation; neurodegeneration
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Guest Editor
Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA
Interests: biomedical engineering; biomaterial design; polymeric nanoparticles; autophagy function; lysosomal acidification; metabolic disorders; non-alcoholic fatty liver disease; type II diabetes; neurodegenerative disease; Parkinson’s disease
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore 117583, Singapore
Interests: microcirculation; blood rheology; microfluidics; medical devices; biomaterials; biosensors; proteomics

Special Issue Information

Dear Colleagues,

Proteins are some of the most versatile and well-studied macromolecules that can be incorporated into cells and biomaterials for the engineering of biosensors with biomedical applications. Protein-based biosensors and biomaterials have gained special attentions as they offer new opportunities in the development of high-throughput screening platforms for drug discovery, laboratory and point-of-care diagnostics, and theranostic tools. Cell-based biosensors have been widely used in the selection of chemical compounds with new pharmaceutical formulations in protein targeting through high-throughput screening to generate lead drug candidates. Similarly, polymeric and lipid-based nanoparticles and nanovesicles have been developed as nanomedicine as well as biosensing tools for biomedical applications and the goal is to translate these therapies and tools into the clinics. We invite authors to submit original articles and review articles highlighting the latest advances in protein-based biosensors and biomaterials with high sensitivity and specificity as well as potential for miniaturization, mass production, and high-throughput applications.

Dr. Chih Hung Lo
Dr. Jialiu Zeng
Dr. Justin Kok Soon Tan
Guest Editors

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Keywords

  • cell-based biosensors
  • biomaterial-based biosensors
  • biomedical engineering
  • high-throughput screening
  • small molecules
  • nanomedicine
  • theranostic applications
  • polymeric materials
  • lipid-based materials
  • self-assembly

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Published Papers (1 paper)

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Review

25 pages, 6665 KiB  
Review
Blood–Brain Barrier-Targeting Nanoparticles: Biomaterial Properties and Biomedical Applications in Translational Neuroscience
by Evridiki Asimakidou, Justin Kok Soon Tan, Jialiu Zeng and Chih Hung Lo
Pharmaceuticals 2024, 17(5), 612; https://doi.org/10.3390/ph17050612 - 10 May 2024
Cited by 26 | Viewed by 5655
Abstract
Overcoming the blood–brain barrier (BBB) remains a significant hurdle in effective drug delivery to the brain. While the BBB serves as a crucial protective barrier, it poses challenges in delivering therapeutic agents to their intended targets within the brain parenchyma. To enhance drug [...] Read more.
Overcoming the blood–brain barrier (BBB) remains a significant hurdle in effective drug delivery to the brain. While the BBB serves as a crucial protective barrier, it poses challenges in delivering therapeutic agents to their intended targets within the brain parenchyma. To enhance drug delivery for the treatment of neurological diseases, several delivery technologies to circumvent the BBB have been developed in the last few years. Among them, nanoparticles (NPs) are one of the most versatile and promising tools. Here, we summarize the characteristics of NPs that facilitate BBB penetration, including their size, shape, chemical composition, surface charge, and importantly, their conjugation with various biological or synthetic molecules such as glucose, transferrin, insulin, polyethylene glycol, peptides, and aptamers. Additionally, we discuss the coating of NPs with surfactants. A comprehensive overview of the common in vitro and in vivo models of the BBB for NP penetration studies is also provided. The discussion extends to discussing BBB impairment under pathological conditions and leveraging BBB alterations under pathological conditions to enhance drug delivery. Emphasizing the need for future studies to uncover the inherent therapeutic properties of NPs, the review advocates for their role beyond delivery systems and calls for efforts translating NPs to the clinic as therapeutics. Overall, NPs stand out as a highly promising therapeutic strategy for precise BBB targeting and drug delivery in neurological disorders. Full article
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