Mosquito-Borne Viral Infections in Africa

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 10046

Special Issue Editors


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Guest Editor
1. Department of Virology, Medicum, University of Helsinki, FI-00290 Helsinki, Finland
2. Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, FI-00014 Helsinki, Finland
Interests: mosquito-borne viruses; vector-borne zoonoses
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Virology, Medicum, University of Helsinki, FI-00290 Helsinki, Finland
2. Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, FI-00014 Helsinki, Finland
Interests: mosquito-borne viruses; tick-borne viruses; emerging infections; vector ecology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Whereas significant research efforts have been targeted to mosquito-borne (MB) viral infections such as DENV and ZIKV in other parts of the world, a significant information gap exists for Africa. As the geographical origin of many of the currently globally important MB viruses, Africa is an interesting location in which to study these viruses. The lack of diagnostic capacity has hampered the detection of MB diseases in many African countries, thus leaving the overall epidemiological situation and pathogen diversity unknown. The available sporadic information demonstrates the current epidemic circulation of pathogens such as DENV, ZIKV, CHIKV, and RVFV in several countries. These, however, represent only a small fraction of the described arboviruses in Africa that include many lesser known viruses. Several local factors are likely to play a role in arbovirus dynamics and ecology in Africa, which may differ from one region to another. These include, for example, the sylvatic cycles in primates, diverse mosquito fauna, and human activities. The rural communities that live in close proximity to wildlife may also provide a way for new arboviruses to emerge. This Special Issue will review and gather information for a comprehensive update on the current understanding of the African arbovirus scene. We invite researchers engaged in arbovirology to submit their work to this Special Issue focused on the diversity and future prospects of arboviral pathogens in Africa.

Dr. Eili Huhtamo
Dr. Essi Korhonen
Guest Editors

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Published Papers (3 papers)

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Research

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9 pages, 1593 KiB  
Article
Shuni Virus Replicates at the Maternal-Fetal Interface of the Ovine and Human Placenta
by Judith Oymans, Lucien van Keulen, Guus M. Vermeulen, Paul J. Wichgers Schreur and Jeroen Kortekaas
Pathogens 2021, 10(1), 17; https://doi.org/10.3390/pathogens10010017 - 29 Dec 2020
Cited by 1 | Viewed by 1955
Abstract
Shuni virus (SHUV) is a neglected teratogenic and neurotropic orthobunyavirus that was discovered in the 1960s in Nigeria and was subsequently detected in South Africa, Zimbabwe, and Israel. The virus was isolated from field-collected biting midges and mosquitoes and shown to disseminate efficiently [...] Read more.
Shuni virus (SHUV) is a neglected teratogenic and neurotropic orthobunyavirus that was discovered in the 1960s in Nigeria and was subsequently detected in South Africa, Zimbabwe, and Israel. The virus was isolated from field-collected biting midges and mosquitoes and shown to disseminate efficiently in laboratory-reared biting midges, suggesting that members of the families Culicidae and Ceratopogonidae may function as vectors. SHUV infections have been associated with severe neurological disease in horses, a variety of wildlife species, and domesticated ruminants. SHUV infection of ruminants is additionally associated with abortion, stillbirth, and congenital malformations. The detection of antibodies in human sera also suggests that the virus may have zoonotic potential. To understand how SHUV crosses the ruminant placenta, we here infected pregnant ewes and subsequently performed detailed clinical- and histopathological examination of placental tissue. We found that SHUV targets both maternal epithelial cells and fetal trophoblasts, that together form the maternal-fetal interface of the ovine placenta. Experiments with human placental explants, furthermore, revealed replication of SHUV in syncytiotrophoblasts, which are generally highly resistant to virus infections. Our findings provide novel insights into vertical transmission of SHUV in sheep and call for research on the potential risk of SHUV infection during human pregnancies. Full article
(This article belongs to the Special Issue Mosquito-Borne Viral Infections in Africa)
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Review

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19 pages, 1968 KiB  
Review
Epidemiology and Laboratory Diagnostics of Dengue, Yellow Fever, Zika, and Chikungunya Virus Infections in Africa
by Awadalkareem Adam and Christian Jassoy
Pathogens 2021, 10(10), 1324; https://doi.org/10.3390/pathogens10101324 - 14 Oct 2021
Cited by 13 | Viewed by 4389
Abstract
Arbovirus infections are widespread, and their disease burden has increased in the past decade. In Africa, arbovirus infections and fever with unknown etiology are common. Due to the lack of well-established epidemiologic surveillance systems and accurate differential diagnosis in most African countries, little [...] Read more.
Arbovirus infections are widespread, and their disease burden has increased in the past decade. In Africa, arbovirus infections and fever with unknown etiology are common. Due to the lack of well-established epidemiologic surveillance systems and accurate differential diagnosis in most African countries, little is known about the prevalence of human arbovirus infections in Africa. The aim of this review is to summarize the available epidemiological data and diagnostic laboratory tools of infections with dengue, yellow fever, Zika, and chikungunya viruses, all transmitted by Aedes mosquitoes. Studies indicate that these arboviral infections are endemic in most of Africa. Surveillance of the incidence and prevalence of the infections would enable medical doctors to improve the diagnostic accuracy in patients with typical symptoms. If possible, arboviral diagnostic tests should be added to the routine healthcare systems. Healthcare providers should be informed about the prevalent arboviral diseases to identify possible cases. Full article
(This article belongs to the Special Issue Mosquito-Borne Viral Infections in Africa)
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15 pages, 1755 KiB  
Review
Mosquito-Borne Viral Pathogens Detected in Zambia: A Systematic Review
by Rachel Milomba Velu, Geoffrey Kwenda, Liyali Libonda, Caroline Cleopatra Chisenga, Bumbangi Nsoni Flavien, Obvious Nchimunya Chilyabanyama, Michelo Simunyandi, Samuel Bosomprah, Nicholus Chintu Sande, Katendi Changula, Walter Muleya, Monicah Mirai Mburu, Benjamin Mubemba, Simbarashe Chitanga, John Tembo, Matthew Bates, Nathan Kapata, Yasuko Orba, Masahiro Kajihara, Ayato Takada, Hirofumi Sawa, Roma Chilengi and Edgar Simulunduadd Show full author list remove Hide full author list
Pathogens 2021, 10(8), 1007; https://doi.org/10.3390/pathogens10081007 - 10 Aug 2021
Cited by 6 | Viewed by 3224
Abstract
Emerging and re-emerging mosquito-borne viral diseases are a threat to global health. This systematic review aimed to investigate the available evidence of mosquito-borne viral pathogens reported in Zambia. A search of literature was conducted in PubMed and Google Scholar for articles published from [...] Read more.
Emerging and re-emerging mosquito-borne viral diseases are a threat to global health. This systematic review aimed to investigate the available evidence of mosquito-borne viral pathogens reported in Zambia. A search of literature was conducted in PubMed and Google Scholar for articles published from 1 January 1930 to 30 June 2020 using a combination of keywords. Eight mosquito-borne viruses belonging to three families, Togaviridae, Flaviviridae and Phenuiviridae were reported. Three viruses (Chikungunya virus, Mayaro virus, Mwinilunga virus) were reported among the togaviruses whilst four (dengue virus, West Nile virus, yellow fever virus, Zika virus) were among the flavivirus and only one virus, Rift Valley fever virus, was reported in the Phenuiviridae family. The majority of these mosquito-borne viruses were reported in Western and North-Western provinces. Aedes and Culex species were the main mosquito-borne viral vectors reported. Farming, fishing, movement of people and rain patterns were among factors associated with mosquito-borne viral infection in Zambia. Better diagnostic methods, such as the use of molecular tools, to detect the viruses in potential vectors, humans, and animals, including the recognition of arboviral risk zones and how the viruses circulate, are important for improved surveillance and design of effective prevention and control measures. Full article
(This article belongs to the Special Issue Mosquito-Borne Viral Infections in Africa)
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