Innovative Approaches to Antibody-Mediated Therapies for Infectious Diseases
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Immunological Responses and Immune Defense Mechanisms".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 7
Special Issue Editor
Interests: antibody discovery and engineering; autoimmunity; basic immunology; T-cell; B-cell and dendritic cell biology; anti-infectious immune response
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antibody-mediated therapies are revolutionizing the fight against infectious diseases, offering new and innovative approaches to prevention and treatment. Monoclonal antibodies (mAbs) mimic the natural antibodies the body generates to combat infections. MAbs are engineered to specifically target and neutralize pathogens or block their ability to infect cells. This approach has proven particularly effective against viral infections like COVID-19 and Respiratory Syncytial Virus (RSV), where specific mAbs have received emergency use authorization and are actively being used to treat or prevent infections. However, a mAb targeting a specific epitope will allow escape variants to excessively grow, causing new variant strains to become dominant and resistant to treatment using that mAb. Methods to mitigate escape include adding mAbs to cocktails, creating scFv, bi-specific, or antibody drug conjugates, but these strategies have also been challenged by the potential development of escape mutations. New technologies Also, other techniques like effector function, prolonging the half-life, reducing immunogenicity, and targeting conserved pathways are actively being applied to modify antibodies to enhance their efficacy and safety in treating infectious diseases.
Dr. Adinarayana Kunamneni
Guest Editor
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Keywords
- phage and ribosome display
- display technologies
- single-cell analysis and artificial intelligence (AI)
- recombinant antibody formats
- humanization and affinity maturation
- optimization
- physiochemical properties
- infectious diseases
- prophylactic
- therapeutic
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