The Role of Viral Infection in Sarcoma

Dear Colleagues,

Viral infections represent a significant global health concern, contributing to approximately 15% of all cancer cases worldwide. Viral oncogenesis is primarily achieved through multiple mechanisms, including signaling pathways mediated by viral proteins, chronic inflammation resulting from persistent infection, and the disruption of tumor suppressor genes and host oncogenes involved in cell growth. Viral infections can play a role in the development of sarcoma. For example, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) is a known cause of Kaposi's sarcoma, particularly in immunocompromised individuals. Understanding the molecular mechanisms through which these oncogenic viruses interact with host cells and disrupt normal cellular processes to promote sarcomagenesis is vital in developing effective preventive and therapeutic strategies. This Special Issue will highlight the latest advancements in the field of viral infection in sarcoma and the development of preventative measures and treatments for sarcomas of viral origin. We encourage submissions on a wide range of topics related to viral sarcomagenesis.

Dr. Julian Naipauer
Guest Editor

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